Article: Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma

File Download Links for fulltext
(May Require Subscription)
Supplementary

  • Basic View
  • Metadata View
  • XML View
TitleCombined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma
AuthorsFu, QL1 4
Li, X4
Yip, HK1 2
Shao, Z3
Wu, W1 4
Mi, S3
So, KF1 2
Keywordsneural cells
neuronal survival
neurotrophic factors
ocular hypertension
TrkB
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
CitationNeuroscience, 2009, v. 162 n. 2, p. 375-382 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroscience.2009.04.075
AbstractGlaucoma is a progressive neuropathy characterized by loss of vision as a result of retinal ganglion cell (RGC) death. There are no effective neuroprotectants to treat this disorder. Brain-derived neurotrophic factor (BDNF) is well known to transiently delay RGC death in ocular hypertensive eyes. The CNS-specific leucine-rich repeat protein LINGO-1 contributes to the negative regulation to some trophic pathways. We thereby examined whether BDNF combined with LINGO-1 antagonists can promote long-term RGC survival after ocular hypertension. In this study, intraocular pressure was elevated in adult rats using an argon laser to photocoagulate the episcleral and limbal veins. BDNF alone shows slight neuroprotection to RGCs after a long-term progress of 4 weeks following the induction of ocular hypertension. However, combination of BDNF and LINGO-1-Fc prevents RGC death in the same condition. We further identified that (1) LINGO-1 was co-expressed with BDNF receptor, TrkB in the RGCs, and (2) BDNF combined with LINGO-1-Fc activated more TrkB in the injured retina compared to BDNF alone. These results indicate that the combination of BDNF with LINGO-1 antagonist can provide long-term protection for RGCs in a chronic ocular hypertension model. TrkB may be the predominant mediator of this neuroprotection. © 2009 IBRO.
ISSN0306-4522
2011 Impact Factor: 3.38
2011 SCImago Journal Rankings: 0.284
DOIhttp://dx.doi.org/10.1016/j.neuroscience.2009.04.075
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorFu, QL
dc.contributor.authorLi, X
dc.contributor.authorYip, HK
dc.contributor.authorShao, Z
dc.contributor.authorWu, W
dc.contributor.authorMi, S
dc.contributor.authorSo, KF
dc.date.accessioned2010-05-31T03:26:01Z
dc.date.available2010-05-31T03:26:01Z
dc.date.issued2009
dc.description.abstractGlaucoma is a progressive neuropathy characterized by loss of vision as a result of retinal ganglion cell (RGC) death. There are no effective neuroprotectants to treat this disorder. Brain-derived neurotrophic factor (BDNF) is well known to transiently delay RGC death in ocular hypertensive eyes. The CNS-specific leucine-rich repeat protein LINGO-1 contributes to the negative regulation to some trophic pathways. We thereby examined whether BDNF combined with LINGO-1 antagonists can promote long-term RGC survival after ocular hypertension. In this study, intraocular pressure was elevated in adult rats using an argon laser to photocoagulate the episcleral and limbal veins. BDNF alone shows slight neuroprotection to RGCs after a long-term progress of 4 weeks following the induction of ocular hypertension. However, combination of BDNF and LINGO-1-Fc prevents RGC death in the same condition. We further identified that (1) LINGO-1 was co-expressed with BDNF receptor, TrkB in the RGCs, and (2) BDNF combined with LINGO-1-Fc activated more TrkB in the injured retina compared to BDNF alone. These results indicate that the combination of BDNF with LINGO-1 antagonist can provide long-term protection for RGCs in a chronic ocular hypertension model. TrkB may be the predominant mediator of this neuroprotection. © 2009 IBRO.
dc.description.naturepostprint
dc.identifier.citationNeuroscience, 2009, v. 162 n. 2, p. 375-382 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroscience.2009.04.075
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroscience.2009.04.075
dc.identifier.epage382
dc.identifier.hkuros173300
dc.identifier.hkuros161256
dc.identifier.isiWOS:000267787500015
Funding AgencyGrant Number
NSFC30801272
RFDP200805581160
Natural Science Foundation of Guangdong Province of China8451008901000852
Science and Technology Foundation of Guangdong Province of China2006B36004010
Funding Information:

This study was supported by funding from the Jessie Ho Professorship in Neuroscience (The University of Hong Kong Foundation for Educational Development and Research Limited, and donation from Mr. George Ho), and donations from Madame Tung Shai Yun, and Madame Annie Tsao Wen Wei. This research was also supported by grants from the NSFC (30801272), RFDP (200805581160), Natural Science Foundation of Guangdong Province of China (8451008901000852) and Science and Technology Foundation of Guangdong Province of China (2006B36004010).

dc.identifier.issn0306-4522
2011 Impact Factor: 3.38
2011 SCImago Journal Rankings: 0.284
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid19422885
dc.identifier.scopuseid_2-s2.0-67649476103
dc.identifier.spage375
dc.identifier.urihttp://hdl.handle.net/10722/58217
dc.identifier.volume162
dc.languageeng
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
dc.publisher.placeNetherlands
dc.relation.ispartofNeuroscience
dc.relation.referencesReferences in Scopus
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshBrain-Derived Neurotrophic Factor - pharmacology - therapeutic use
dc.subject.meshGlaucoma - drug therapy - pathology - physiopathology
dc.subject.meshMembrane Proteins - biosynthesis - genetics
dc.subject.meshNerve Tissue Proteins - biosynthesis - genetics
dc.subject.meshNeuroprotective Agents - pharmacology - therapeutic use
dc.subjectneural cells
dc.subjectneuronal survival
dc.subjectneurotrophic factors
dc.subjectocular hypertension
dc.subjectTrkB
dc.titleCombined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Biogen IDEC
  4. Sun Yat-Sen University