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Article: Neurotrophic Factor Treatment after Spinal Root Avulsion Injury

TitleNeurotrophic Factor Treatment after Spinal Root Avulsion Injury
Authors
Issue Date2009
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cnsamc
Citation
Central Nervous System Agents in Medicinal Chemistry, 2009, v. 9 n. 1, p. 40-55 How to Cite?
AbstractSpinal root avulsion injury causes motoneuron death and immediate loss of sensory and motor functions. Surgical intervention such as reimplantation of avulsed root is proven useful to restore neural circuitry of spinal cord and targeted muscles. Yet, additional strategies are required for faster and better functional recovery which is overall unsatisfactory. Accumulating evidences in animal studies, particularly in peripheral nerve injuries, demonstrated the effectiveness of neurotrophic factors in rescuing injured motoneurons and promoting axon regeneration. It is, however, important to recognize the differences between peripheral nerve and avulsion injury. In this review, we will briefly describe the changes in motoneurons after avulsion and provides a comprehensive list of neurotrophic factors which are known to exert neuroprotective effects on motoneurons. We will include recent studies on trophic factors for motoneuron survival and regeneration in peripheral nerve and avulsion injuries. We will also discuss the potential use of trophic factors in the context of avulsion injuries.
Persistent Identifierhttp://hdl.handle.net/10722/58208
ISSN
2015 SCImago Journal Rankings: 0.487

 

DC FieldValueLanguage
dc.contributor.authorChu, THen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-05-31T03:25:51Z-
dc.date.available2010-05-31T03:25:51Z-
dc.date.issued2009en_HK
dc.identifier.citationCentral Nervous System Agents in Medicinal Chemistry, 2009, v. 9 n. 1, p. 40-55en_HK
dc.identifier.issn1871-5249en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58208-
dc.description.abstractSpinal root avulsion injury causes motoneuron death and immediate loss of sensory and motor functions. Surgical intervention such as reimplantation of avulsed root is proven useful to restore neural circuitry of spinal cord and targeted muscles. Yet, additional strategies are required for faster and better functional recovery which is overall unsatisfactory. Accumulating evidences in animal studies, particularly in peripheral nerve injuries, demonstrated the effectiveness of neurotrophic factors in rescuing injured motoneurons and promoting axon regeneration. It is, however, important to recognize the differences between peripheral nerve and avulsion injury. In this review, we will briefly describe the changes in motoneurons after avulsion and provides a comprehensive list of neurotrophic factors which are known to exert neuroprotective effects on motoneurons. We will include recent studies on trophic factors for motoneuron survival and regeneration in peripheral nerve and avulsion injuries. We will also discuss the potential use of trophic factors in the context of avulsion injuries.-
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cnsamcen_HK
dc.relation.ispartofCentral Nervous System Agents in Medicinal Chemistryen_HK
dc.subject.meshMotor Neurons - physiology-
dc.subject.meshNerve Growth Factors - physiology-
dc.subject.meshNerve Regeneration - physiology-
dc.subject.meshNeuronal Plasticity - physiology-
dc.subject.meshSpinal Cord - pathology-
dc.titleNeurotrophic Factor Treatment after Spinal Root Avulsion Injuryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1871-5249&volume=9&spage=40&epage=55&date=2009&atitle=Neurotrophic+Factor+Treatment+after+Spinal+Root+Avulsion+Injuryen_HK
dc.identifier.emailChu, TH: chuth@graduate.hku.hken_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/187152409787601914-
dc.identifier.pmid20021337-
dc.identifier.scopuseid_2-s2.0-62549107119-
dc.identifier.hkuros154825en_HK
dc.identifier.issue1-
dc.identifier.citeulike4153373-

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