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Article: Impediments to eye transplantation: Ocular viability following optic-nerve transection or enucleation

TitleImpediments to eye transplantation: Ocular viability following optic-nerve transection or enucleation
Authors
Issue Date2009
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal Of Ophthalmology, 2009, v. 93 n. 9, p. 1134-1140 How to Cite?
AbstractMaintenance of ocular viability is one of the major impediments to successful whole-eye transplantation. This review provides a comprehensive understanding of the current literature to help guide future studies in order to overcome this hurdle. A systematic multistage review of published literature was performed. Three specific questions were addressed: (1) Is recovery of visual function following eye transplantation greater in cold-blooded vertebrates when compared with mammals? (2) Is outer retina function following enucleation and reperfusion improved compared with enucleation alone? (3) Following optic-nerve transection, is there a correlation between retinal ganglion cell (RGC) survival and either time after transection or proximity of the transection to the globe? In a majority of the studies performed in the literature, recovery of visual function can occur after whole-eye transplantation in cold-blooded vertebrates. Following enucleation (and reperfusion), outer retinal function is maintained from 4 to 9 h. RGC survival following optic-nerve transection is inversely related to both the time since transection and the proximity of transection to the globe. Lastly, neurotrophins can increase RGC survival following optic-nerve transection. This review of the literature suggests that the use of a donor eye is feasible for whole-eye transplantation.
Persistent Identifierhttp://hdl.handle.net/10722/58203
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.873
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
NIHP30-001792
Research to Prevent Blindness (New York)
Funding Information:

Supported by: NIH P30-001792 (DTA) and an unrestricted departmental support from Research to Prevent Blindness (New York).

References

 

DC FieldValueLanguage
dc.contributor.authorEllenberg, Den_HK
dc.contributor.authorShi, Jen_HK
dc.contributor.authorJain, Sen_HK
dc.contributor.authorChang, JHen_HK
dc.contributor.authorRipps, Hen_HK
dc.contributor.authorBrady, Sen_HK
dc.contributor.authorMelhem, ERen_HK
dc.contributor.authorLakkis, Fen_HK
dc.contributor.authorAdamis, Aen_HK
dc.contributor.authorChen, DFen_HK
dc.contributor.authorEllisBehnke, Ren_HK
dc.contributor.authorLanger, RSen_HK
dc.contributor.authorStrittmatter, SMen_HK
dc.contributor.authorAzar, DTen_HK
dc.date.accessioned2010-05-31T03:25:46Z-
dc.date.available2010-05-31T03:25:46Z-
dc.date.issued2009en_HK
dc.identifier.citationBritish Journal Of Ophthalmology, 2009, v. 93 n. 9, p. 1134-1140en_HK
dc.identifier.issn0007-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58203-
dc.description.abstractMaintenance of ocular viability is one of the major impediments to successful whole-eye transplantation. This review provides a comprehensive understanding of the current literature to help guide future studies in order to overcome this hurdle. A systematic multistage review of published literature was performed. Three specific questions were addressed: (1) Is recovery of visual function following eye transplantation greater in cold-blooded vertebrates when compared with mammals? (2) Is outer retina function following enucleation and reperfusion improved compared with enucleation alone? (3) Following optic-nerve transection, is there a correlation between retinal ganglion cell (RGC) survival and either time after transection or proximity of the transection to the globe? In a majority of the studies performed in the literature, recovery of visual function can occur after whole-eye transplantation in cold-blooded vertebrates. Following enucleation (and reperfusion), outer retinal function is maintained from 4 to 9 h. RGC survival following optic-nerve transection is inversely related to both the time since transection and the proximity of transection to the globe. Lastly, neurotrophins can increase RGC survival following optic-nerve transection. This review of the literature suggests that the use of a donor eye is feasible for whole-eye transplantation.en_HK
dc.languageengen_HK
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_HK
dc.relation.ispartofBritish Journal of Ophthalmologyen_HK
dc.rightsBritish Journal of Ophthalmology. Copyright © BMJ Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshEye - physiopathology - transplantation-
dc.subject.meshEye Enucleation - adverse effects-
dc.subject.meshOptic Nerve Injuries - complications - physiopathology-
dc.subject.meshRetina - physiology-
dc.subject.meshRetinal Ganglion Cells - physiology-
dc.titleImpediments to eye transplantation: Ocular viability following optic-nerve transection or enucleationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1161&volume=93&issue=9&spage=1134&epage=1140&date=2009&atitle=Impediments+to+eye+transplantation:+ocular+viability+following+optic+nerve+transection+or+enucleationen_HK
dc.identifier.emailEllisBehnke, R: rutledg@mit.eduen_HK
dc.identifier.authorityEllisBehnke, R=rp00252en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1136/bjo.2008.155267en_HK
dc.identifier.pmid19286686-
dc.identifier.pmcidPMC2850278-
dc.identifier.scopuseid_2-s2.0-70249134612en_HK
dc.identifier.hkuros162717en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70249134612&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume93en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1134en_HK
dc.identifier.epage1140en_HK
dc.identifier.isiWOS:000270135500003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridEllenberg, D=14059790000en_HK
dc.identifier.scopusauthoridShi, J=34877745500en_HK
dc.identifier.scopusauthoridJain, S=35184745300en_HK
dc.identifier.scopusauthoridChang, JH=22333289500en_HK
dc.identifier.scopusauthoridRipps, H=7005410758en_HK
dc.identifier.scopusauthoridBrady, S=16214595400en_HK
dc.identifier.scopusauthoridMelhem, ER=36896184700en_HK
dc.identifier.scopusauthoridLakkis, F=36874048300en_HK
dc.identifier.scopusauthoridAdamis, A=7004411843en_HK
dc.identifier.scopusauthoridChen, DF=26027705500en_HK
dc.identifier.scopusauthoridEllisBehnke, R=8548055200en_HK
dc.identifier.scopusauthoridLanger, RS=7402409226en_HK
dc.identifier.scopusauthoridStrittmatter, SM=7005210588en_HK
dc.identifier.scopusauthoridAzar, DT=26643368400en_HK

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