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Article: Impediments to eye transplantation: Ocular viability following optic-nerve transection or enucleation
Title | Impediments to eye transplantation: Ocular viability following optic-nerve transection or enucleation | ||||||
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Authors | |||||||
Issue Date | 2009 | ||||||
Publisher | BMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/ | ||||||
Citation | British Journal Of Ophthalmology, 2009, v. 93 n. 9, p. 1134-1140 How to Cite? | ||||||
Abstract | Maintenance of ocular viability is one of the major impediments to successful whole-eye transplantation. This review provides a comprehensive understanding of the current literature to help guide future studies in order to overcome this hurdle. A systematic multistage review of published literature was performed. Three specific questions were addressed: (1) Is recovery of visual function following eye transplantation greater in cold-blooded vertebrates when compared with mammals? (2) Is outer retina function following enucleation and reperfusion improved compared with enucleation alone? (3) Following optic-nerve transection, is there a correlation between retinal ganglion cell (RGC) survival and either time after transection or proximity of the transection to the globe? In a majority of the studies performed in the literature, recovery of visual function can occur after whole-eye transplantation in cold-blooded vertebrates. Following enucleation (and reperfusion), outer retinal function is maintained from 4 to 9 h. RGC survival following optic-nerve transection is inversely related to both the time since transection and the proximity of transection to the globe. Lastly, neurotrophins can increase RGC survival following optic-nerve transection. This review of the literature suggests that the use of a donor eye is feasible for whole-eye transplantation. | ||||||
Persistent Identifier | http://hdl.handle.net/10722/58203 | ||||||
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.862 | ||||||
PubMed Central ID | |||||||
ISI Accession Number ID |
Funding Information: Supported by: NIH P30-001792 (DTA) and an unrestricted departmental support from Research to Prevent Blindness (New York). | ||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ellenberg, D | en_HK |
dc.contributor.author | Shi, J | en_HK |
dc.contributor.author | Jain, S | en_HK |
dc.contributor.author | Chang, JH | en_HK |
dc.contributor.author | Ripps, H | en_HK |
dc.contributor.author | Brady, S | en_HK |
dc.contributor.author | Melhem, ER | en_HK |
dc.contributor.author | Lakkis, F | en_HK |
dc.contributor.author | Adamis, A | en_HK |
dc.contributor.author | Chen, DF | en_HK |
dc.contributor.author | EllisBehnke, R | en_HK |
dc.contributor.author | Langer, RS | en_HK |
dc.contributor.author | Strittmatter, SM | en_HK |
dc.contributor.author | Azar, DT | en_HK |
dc.date.accessioned | 2010-05-31T03:25:46Z | - |
dc.date.available | 2010-05-31T03:25:46Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | British Journal Of Ophthalmology, 2009, v. 93 n. 9, p. 1134-1140 | en_HK |
dc.identifier.issn | 0007-1161 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/58203 | - |
dc.description.abstract | Maintenance of ocular viability is one of the major impediments to successful whole-eye transplantation. This review provides a comprehensive understanding of the current literature to help guide future studies in order to overcome this hurdle. A systematic multistage review of published literature was performed. Three specific questions were addressed: (1) Is recovery of visual function following eye transplantation greater in cold-blooded vertebrates when compared with mammals? (2) Is outer retina function following enucleation and reperfusion improved compared with enucleation alone? (3) Following optic-nerve transection, is there a correlation between retinal ganglion cell (RGC) survival and either time after transection or proximity of the transection to the globe? In a majority of the studies performed in the literature, recovery of visual function can occur after whole-eye transplantation in cold-blooded vertebrates. Following enucleation (and reperfusion), outer retinal function is maintained from 4 to 9 h. RGC survival following optic-nerve transection is inversely related to both the time since transection and the proximity of transection to the globe. Lastly, neurotrophins can increase RGC survival following optic-nerve transection. This review of the literature suggests that the use of a donor eye is feasible for whole-eye transplantation. | en_HK |
dc.language | eng | en_HK |
dc.publisher | BMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/ | en_HK |
dc.relation.ispartof | British Journal of Ophthalmology | en_HK |
dc.rights | British Journal of Ophthalmology. Copyright © BMJ Publishing Group. | en_HK |
dc.subject.mesh | Eye - physiopathology - transplantation | - |
dc.subject.mesh | Eye Enucleation - adverse effects | - |
dc.subject.mesh | Optic Nerve Injuries - complications - physiopathology | - |
dc.subject.mesh | Retina - physiology | - |
dc.subject.mesh | Retinal Ganglion Cells - physiology | - |
dc.title | Impediments to eye transplantation: Ocular viability following optic-nerve transection or enucleation | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1161&volume=93&issue=9&spage=1134&epage=1140&date=2009&atitle=Impediments+to+eye+transplantation:+ocular+viability+following+optic+nerve+transection+or+enucleation | en_HK |
dc.identifier.email | EllisBehnke, R: rutledg@mit.edu | en_HK |
dc.identifier.authority | EllisBehnke, R=rp00252 | en_HK |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.1136/bjo.2008.155267 | en_HK |
dc.identifier.pmid | 19286686 | - |
dc.identifier.pmcid | PMC2850278 | - |
dc.identifier.scopus | eid_2-s2.0-70249134612 | en_HK |
dc.identifier.hkuros | 162717 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-70249134612&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 93 | en_HK |
dc.identifier.issue | 9 | en_HK |
dc.identifier.spage | 1134 | en_HK |
dc.identifier.epage | 1140 | en_HK |
dc.identifier.isi | WOS:000270135500003 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Ellenberg, D=14059790000 | en_HK |
dc.identifier.scopusauthorid | Shi, J=34877745500 | en_HK |
dc.identifier.scopusauthorid | Jain, S=35184745300 | en_HK |
dc.identifier.scopusauthorid | Chang, JH=22333289500 | en_HK |
dc.identifier.scopusauthorid | Ripps, H=7005410758 | en_HK |
dc.identifier.scopusauthorid | Brady, S=16214595400 | en_HK |
dc.identifier.scopusauthorid | Melhem, ER=36896184700 | en_HK |
dc.identifier.scopusauthorid | Lakkis, F=36874048300 | en_HK |
dc.identifier.scopusauthorid | Adamis, A=7004411843 | en_HK |
dc.identifier.scopusauthorid | Chen, DF=26027705500 | en_HK |
dc.identifier.scopusauthorid | EllisBehnke, R=8548055200 | en_HK |
dc.identifier.scopusauthorid | Langer, RS=7402409226 | en_HK |
dc.identifier.scopusauthorid | Strittmatter, SM=7005210588 | en_HK |
dc.identifier.scopusauthorid | Azar, DT=26643368400 | en_HK |
dc.identifier.issnl | 0007-1161 | - |