Article: The potential role of nitric oxide synthase in survival and regeneration of magnocellular neurons of hypothalamo-neurohypophyseal system

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TitleThe potential role of nitric oxide synthase in survival and regeneration of magnocellular neurons of hypothalamo-neurohypophyseal system
AuthorsYuan, Q1 4
Scott, DE3
So, KF1
Lin, Z4
Wu, W1 2
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0364-3190
CitationNeurochemical Research, 2009, v. 34 n. 11, p. 1907-1913 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11064-009-9965-0
AbstractPrevious investigations from this laboratory have demonstrated that hypophysectomy induces up-regulation of neuronal nitric oxide synthase (nNOS) in magnocellular neurons of the mammalian hypothalamo-neurohypophyseal system (HNS). Accompanied by this upregulation of nNOS, both neuronal regeneration and degeneration are also observed in this system following hypophysectomy. The specific aim of this study was to determine the potential role of nNOS upregulation in neuronal survival and regeneration after hypophysectomy in the adult Sprague-Dawley (SD) rat by using a competitive nitric oxide synthase blocker, N(G)-nitrol-l-arginine methyl ester (l-NAME). We found that l-NAME treatment effectively blocked the regeneration of magnocellular neurons of the rodent hypothalamus as observed in the lumen of the third cerebral ventricle following hypophysectomy. However, l-NAME had no effect on the survival of magnocellular neurons in the supraoptic (SON) and paraventricular (PVN) nuclei after hypophysectomy. These results suggest that the induced increase of nNOS expression enhance the regenerative ability of magnocellular neurons of the HNS following hypophysectomy. © 2009 Springer Science+Business Media, LLC.
ISSN0364-3190
2011 Impact Factor: 2.24
2011 SCImago Journal Rankings: 0.168
DOIhttp://dx.doi.org/10.1007/s11064-009-9965-0
ISI Accession Number IDWOS:000269914400003
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYuan, Q
dc.contributor.authorScott, DE
dc.contributor.authorSo, KF
dc.contributor.authorLin, Z
dc.contributor.authorWu, W
dc.date.accessioned2010-05-31T03:25:34Z
dc.date.available2010-05-31T03:25:34Z
dc.date.issued2009
dc.description.abstractPrevious investigations from this laboratory have demonstrated that hypophysectomy induces up-regulation of neuronal nitric oxide synthase (nNOS) in magnocellular neurons of the mammalian hypothalamo-neurohypophyseal system (HNS). Accompanied by this upregulation of nNOS, both neuronal regeneration and degeneration are also observed in this system following hypophysectomy. The specific aim of this study was to determine the potential role of nNOS upregulation in neuronal survival and regeneration after hypophysectomy in the adult Sprague-Dawley (SD) rat by using a competitive nitric oxide synthase blocker, N(G)-nitrol-l-arginine methyl ester (l-NAME). We found that l-NAME treatment effectively blocked the regeneration of magnocellular neurons of the rodent hypothalamus as observed in the lumen of the third cerebral ventricle following hypophysectomy. However, l-NAME had no effect on the survival of magnocellular neurons in the supraoptic (SON) and paraventricular (PVN) nuclei after hypophysectomy. These results suggest that the induced increase of nNOS expression enhance the regenerative ability of magnocellular neurons of the HNS following hypophysectomy. © 2009 Springer Science+Business Media, LLC.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNeurochemical Research, 2009, v. 34 n. 11, p. 1907-1913 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11064-009-9965-0
dc.identifier.citeulike4383100
dc.identifier.doihttp://dx.doi.org/10.1007/s11064-009-9965-0
dc.identifier.epage1913
dc.identifier.hkuros163983
dc.identifier.isiWOS:000269914400003
dc.identifier.issn0364-3190
2011 Impact Factor: 2.24
2011 SCImago Journal Rankings: 0.168
dc.identifier.issue11
dc.identifier.openurl
dc.identifier.pmid19381805
dc.identifier.scopuseid_2-s2.0-70349606148
dc.identifier.spage1907
dc.identifier.urihttp://hdl.handle.net/10722/58193
dc.identifier.volume34
dc.languageeng
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0364-3190
dc.publisher.placeUnited States
dc.relation.ispartofNeurochemical Research
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshCell Survival
dc.subject.meshHypophysectomy
dc.subject.meshHypothalamo-Hypophyseal System - cytology - drug effects
dc.subject.meshMale
dc.subject.meshNG-Nitroarginine Methyl Ester - pharmacology
dc.subject.meshNeuronal Plasticity
dc.subject.meshNeurons - cytology - physiology
dc.subject.meshNitric Oxide Synthase Type I - antagonists & inhibitors - physiology
dc.subject.meshParaventricular Hypothalamic Nucleus - cytology - drug effects
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshRegeneration
dc.subject.meshSupraoptic Nucleus - cytology - drug effects
dc.titleThe potential role of nitric oxide synthase in survival and regeneration of magnocellular neurons of hypothalamo-neurohypophyseal system
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Eastern Virginia Medical School
  4. Chinese University of Hong Kong