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Article: The potential role of nitric oxide synthase in survival and regeneration of magnocellular neurons of hypothalamo-neurohypophyseal system
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TitleThe potential role of nitric oxide synthase in survival and regeneration of magnocellular neurons of hypothalamo-neurohypophyseal system
 
AuthorsYuan, Q1 4
Scott, DE3
So, KF1
Lin, Z4
Wu, W1 2
 
Issue Date2009
 
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0364-3190
 
CitationNeurochemical Research, 2009, v. 34 n. 11, p. 1907-1913 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11064-009-9965-0
 
AbstractPrevious investigations from this laboratory have demonstrated that hypophysectomy induces up-regulation of neuronal nitric oxide synthase (nNOS) in magnocellular neurons of the mammalian hypothalamo-neurohypophyseal system (HNS). Accompanied by this upregulation of nNOS, both neuronal regeneration and degeneration are also observed in this system following hypophysectomy. The specific aim of this study was to determine the potential role of nNOS upregulation in neuronal survival and regeneration after hypophysectomy in the adult Sprague-Dawley (SD) rat by using a competitive nitric oxide synthase blocker, N(G)-nitrol-l-arginine methyl ester (l-NAME). We found that l-NAME treatment effectively blocked the regeneration of magnocellular neurons of the rodent hypothalamus as observed in the lumen of the third cerebral ventricle following hypophysectomy. However, l-NAME had no effect on the survival of magnocellular neurons in the supraoptic (SON) and paraventricular (PVN) nuclei after hypophysectomy. These results suggest that the induced increase of nNOS expression enhance the regenerative ability of magnocellular neurons of the HNS following hypophysectomy. © 2009 Springer Science+Business Media, LLC.
 
ISSN0364-3190
2012 Impact Factor: 2.125
2012 SCImago Journal Rankings: 0.732
 
DOIhttp://dx.doi.org/10.1007/s11064-009-9965-0
 
ISI Accession Number IDWOS:000269914400003
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYuan, Q
 
dc.contributor.authorScott, DE
 
dc.contributor.authorSo, KF
 
dc.contributor.authorLin, Z
 
dc.contributor.authorWu, W
 
dc.date.accessioned2010-05-31T03:25:34Z
 
dc.date.available2010-05-31T03:25:34Z
 
dc.date.issued2009
 
dc.description.abstractPrevious investigations from this laboratory have demonstrated that hypophysectomy induces up-regulation of neuronal nitric oxide synthase (nNOS) in magnocellular neurons of the mammalian hypothalamo-neurohypophyseal system (HNS). Accompanied by this upregulation of nNOS, both neuronal regeneration and degeneration are also observed in this system following hypophysectomy. The specific aim of this study was to determine the potential role of nNOS upregulation in neuronal survival and regeneration after hypophysectomy in the adult Sprague-Dawley (SD) rat by using a competitive nitric oxide synthase blocker, N(G)-nitrol-l-arginine methyl ester (l-NAME). We found that l-NAME treatment effectively blocked the regeneration of magnocellular neurons of the rodent hypothalamus as observed in the lumen of the third cerebral ventricle following hypophysectomy. However, l-NAME had no effect on the survival of magnocellular neurons in the supraoptic (SON) and paraventricular (PVN) nuclei after hypophysectomy. These results suggest that the induced increase of nNOS expression enhance the regenerative ability of magnocellular neurons of the HNS following hypophysectomy. © 2009 Springer Science+Business Media, LLC.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationNeurochemical Research, 2009, v. 34 n. 11, p. 1907-1913 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11064-009-9965-0
 
dc.identifier.citeulike4383100
 
dc.identifier.doihttp://dx.doi.org/10.1007/s11064-009-9965-0
 
dc.identifier.epage1913
 
dc.identifier.hkuros163983
 
dc.identifier.isiWOS:000269914400003
 
dc.identifier.issn0364-3190
2012 Impact Factor: 2.125
2012 SCImago Journal Rankings: 0.732
 
dc.identifier.issue11
 
dc.identifier.openurl
 
dc.identifier.pmid19381805
 
dc.identifier.scopuseid_2-s2.0-70349606148
 
dc.identifier.spage1907
 
dc.identifier.urihttp://hdl.handle.net/10722/58193
 
dc.identifier.volume34
 
dc.languageeng
 
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0364-3190
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNeurochemical Research
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshCell Survival
 
dc.subject.meshHypophysectomy
 
dc.subject.meshHypothalamo-Hypophyseal System - cytology - drug effects
 
dc.subject.meshMale
 
dc.subject.meshNG-Nitroarginine Methyl Ester - pharmacology
 
dc.subject.meshNeuronal Plasticity
 
dc.subject.meshNeurons - cytology - physiology
 
dc.subject.meshNitric Oxide Synthase Type I - antagonists & inhibitors - physiology
 
dc.subject.meshParaventricular Hypothalamic Nucleus - cytology - drug effects
 
dc.subject.meshRats
 
dc.subject.meshRats, Sprague-Dawley
 
dc.subject.meshRegeneration
 
dc.subject.meshSupraoptic Nucleus - cytology - drug effects
 
dc.titleThe potential role of nitric oxide synthase in survival and regeneration of magnocellular neurons of hypothalamo-neurohypophyseal system
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Eastern Virginia Medical School
  4. Chinese University of Hong Kong