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Article: Immediate postconditioning during reperfusion attenuates intestinal injury

TitleImmediate postconditioning during reperfusion attenuates intestinal injury
Authors
Issue Date2009
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00134/index.htm
Citation
Intensive Care Medicine, 2009, v. 35 n. 5, p. 933-942 How to Cite?
AbstractObjective: To test the hypothesis that immediate but not delayed ischemic postconditioning (IPo) during reperfusion attenuates intestinal injury, and that ischemic preconditioning (IPC) and IPo may confer synergy in intestinal protection. Design and setting: Prospective laboratory animal study with concurrent control. Subjects: Adult Sprague-Dawley rats. Interventions: Intestinal ischemia/reperfusion (II/R) injury in rats was produced by clamping superior mesenteric artery for 60 min followed by 60 min reperfusion; IPC was elicited by 10 min ischemia and 10 min reperfusion before index ischemia; IPo was performed by three cycles of 30 s reperfusion and 30 s ischemia initiated either immediately at the onset of reperfusion (IPo) or after reperfusion for 3 min (delayed-IPo). Combination of IPC and IPo was performed by combining both protocols. Measurements and main results: Intestinal ischemia/reperfusion resulted in significant intestinal injury evidenced as significant increase in Chiu's scores and wet-to-dry intestine weight ratio accompanied with increases in plasma levels of tumor necrosis factor-α and interleukin-6, as well as increases in the intestinal tissue lipid peroxidation product malonediadehyde and myeloperoxidase activity as compared to control animals (all P < 0.05). All these changes were significantly attenuated either by IPC or IPo or their combination (P < 0.05), and not by delayed-IPo (P > 0.05). IPC and IPo showed synergistic protection compared with either protocol alone. Conclusion: Ischemic postconditioning reduces intestinal injury, in part, by inhibiting oxidative injury, neutrophils filtration and proinflammatory response. The early period of reperfusion is critical to intestinal protection by IPo, and intestinal protection with IPo can be enhanced by IPC. © 2009 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/58175
ISSN
2015 Impact Factor: 10.125
2015 SCImago Journal Rankings: 3.765
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30672021
Funding Information:

This work is supported by a grant from National Natural Science Foundation of China (No: 30672021, to K.-X. Liu).

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, KXen_HK
dc.contributor.authorLi, YSen_HK
dc.contributor.authorHuang, WQen_HK
dc.contributor.authorChen, SQen_HK
dc.contributor.authorWang, ZXen_HK
dc.contributor.authorLiu, JXen_HK
dc.contributor.authorXia, Zen_HK
dc.date.accessioned2010-05-31T03:25:09Z-
dc.date.available2010-05-31T03:25:09Z-
dc.date.issued2009en_HK
dc.identifier.citationIntensive Care Medicine, 2009, v. 35 n. 5, p. 933-942en_HK
dc.identifier.issn0342-4642en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58175-
dc.description.abstractObjective: To test the hypothesis that immediate but not delayed ischemic postconditioning (IPo) during reperfusion attenuates intestinal injury, and that ischemic preconditioning (IPC) and IPo may confer synergy in intestinal protection. Design and setting: Prospective laboratory animal study with concurrent control. Subjects: Adult Sprague-Dawley rats. Interventions: Intestinal ischemia/reperfusion (II/R) injury in rats was produced by clamping superior mesenteric artery for 60 min followed by 60 min reperfusion; IPC was elicited by 10 min ischemia and 10 min reperfusion before index ischemia; IPo was performed by three cycles of 30 s reperfusion and 30 s ischemia initiated either immediately at the onset of reperfusion (IPo) or after reperfusion for 3 min (delayed-IPo). Combination of IPC and IPo was performed by combining both protocols. Measurements and main results: Intestinal ischemia/reperfusion resulted in significant intestinal injury evidenced as significant increase in Chiu's scores and wet-to-dry intestine weight ratio accompanied with increases in plasma levels of tumor necrosis factor-α and interleukin-6, as well as increases in the intestinal tissue lipid peroxidation product malonediadehyde and myeloperoxidase activity as compared to control animals (all P < 0.05). All these changes were significantly attenuated either by IPC or IPo or their combination (P < 0.05), and not by delayed-IPo (P > 0.05). IPC and IPo showed synergistic protection compared with either protocol alone. Conclusion: Ischemic postconditioning reduces intestinal injury, in part, by inhibiting oxidative injury, neutrophils filtration and proinflammatory response. The early period of reperfusion is critical to intestinal protection by IPo, and intestinal protection with IPo can be enhanced by IPC. © 2009 Springer-Verlag.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00134/index.htmen_HK
dc.relation.ispartofIntensive Care Medicineen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshConditioning (Psychology)en_HK
dc.subject.meshInterleukin-6 - blooden_HK
dc.subject.meshIntestines - blood supply - injuries - metabolismen_HK
dc.subject.meshIschemia - physiopathologyen_HK
dc.subject.meshLipid Peroxidationen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMalondialdehyde - metabolismen_HK
dc.subject.meshNeutrophils - metabolismen_HK
dc.subject.meshOxidative Stress - physiologyen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReperfusion Injury - blood - metabolismen_HK
dc.subject.meshTumor Necrosis Factor-alpha - blooden_HK
dc.titleImmediate postconditioning during reperfusion attenuates intestinal injuryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0342-4642&volume=35&issue=5&spage=933&epage=42&date=2009&atitle=Immediate+postconditioning+during+reperfusion+attenuates+intestinal+injuryen_HK
dc.identifier.emailXia, Z:zyxia@hkucc.hku.hken_HK
dc.identifier.authorityXia, Z=rp00532en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00134-009-1428-1en_HK
dc.identifier.pmid19190893-
dc.identifier.scopuseid_2-s2.0-67349254659en_HK
dc.identifier.hkuros162380en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349254659&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue5en_HK
dc.identifier.spage933en_HK
dc.identifier.epage942en_HK
dc.identifier.isiWOS:000265706900023-
dc.publisher.placeGermanyen_HK
dc.identifier.citeulike4019538-

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