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Article: Nifedipine intake increases the risk for periodontal destruction in subjects with type 2 diabetes mellitus

TitleNifedipine intake increases the risk for periodontal destruction in subjects with type 2 diabetes mellitus
Authors
Issue Date2008
PublisherAmerican Academy of Periodontology. The Journal's web site is located at http://www.perio.org
Citation
Journal Of Periodontology, 2008, v. 79 n. 11, p. 2054-2059 How to Cite?
AbstractBackground: This study investigated the possible association of nifedipine (NIF) intake and diabetes mellitus (DM) with periodontal destruction. Methods: A group of Chinese subjects (N = 1,083, age: 63 ± 8.7 years) were screened. Three hundred fifty-eight non-smokers with hypertension were selected for the study and were grouped based on DM status as non-DM and DM groups, DM(-) and DM(+) respectively. NIF(+) and NIF(-) indicated NIF intake or not. The groups were further divided: NIF(-)/DM(-) (n = 135); NIF(+)/DM(-) (n = 108); NIF(-)/DM(+) (n = 64); and NIF(+)/DM(+) (n = 51). The periodontal conditions in anterior teeth were assessed using plaque index, sulcus bleeding index, clinical attachment loss (AL), probing depth (PD), and the number of missing teeth. Results: Using analysis of covariance, NIF intake was associated with mean PD and extent of PD ≥4 mm in the non-DM and DM groups. The subjects in the NIF(+)/DM(+) subgroup showed greater mean AL and percentage of sites with AL ≥5 mm and AL ≥7 mm than those in NIF(-)/DM(+) subgroup, whereas no significant difference existed between subjects in NIF(-)/DM(-) and NIF(+)/DM(-) subgroups. The NIF(+)/DM(+) subgroup exhibited a greater percentage of sites with AL ≥5 mm (35.5%) compared to the other three subgroups (24.7% for NIF[-]/DM[-], P = 0.004; 25.0% for NIF[+]/DM[-], P = 0.007; and 25.2% for NIF[-]/DM[+], P = 0.016). Logistic regression analysis showed that the NIF(+)/DM(+) subgroup had a significantly higher risk for having 7gt;10% of sites with AL ≥5 mm compared to the NIF(-)/DM(-) subgroup (odds ratio [OR] = 2.9; 95% confidence interval [CI]: 1.2 to 7.4; P = 0.022), the NIF(+)/DM(-) subgroup (OR = 3.1; 95% CI: 1.2 to 8.1; P = 0.020), and the NIF(-)/DM(+) subgroup (OR = 5.1; CI: 1.8 to 14.3; P = 0.002). Conclusion: NIF intake may increase the risk for periodontal destruction in patients with type 2 DM.
Persistent Identifierhttp://hdl.handle.net/10722/58115
ISSN
2015 Impact Factor: 2.844
2015 SCImago Journal Rankings: 1.070
ISI Accession Number ID
Funding AgencyGrant Number
Beijing Municipal Health Bureau, Beijing, China
Funding Information:

This study was supported by Capital Medical Development Fund (2003 to 2005) from the Beijing Municipal Health Bureau, Beijing, China. The authors report no conflicts of interest related to this study.

References

 

DC FieldValueLanguage
dc.contributor.authorLi, Xen_HK
dc.contributor.authorLuan, Qen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorSha, Yen_HK
dc.contributor.authorHe, Len_HK
dc.contributor.authorCao, Cen_HK
dc.contributor.authorJin, Len_HK
dc.date.accessioned2010-05-31T03:24:03Z-
dc.date.available2010-05-31T03:24:03Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Periodontology, 2008, v. 79 n. 11, p. 2054-2059en_HK
dc.identifier.issn0022-3492en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58115-
dc.description.abstractBackground: This study investigated the possible association of nifedipine (NIF) intake and diabetes mellitus (DM) with periodontal destruction. Methods: A group of Chinese subjects (N = 1,083, age: 63 ± 8.7 years) were screened. Three hundred fifty-eight non-smokers with hypertension were selected for the study and were grouped based on DM status as non-DM and DM groups, DM(-) and DM(+) respectively. NIF(+) and NIF(-) indicated NIF intake or not. The groups were further divided: NIF(-)/DM(-) (n = 135); NIF(+)/DM(-) (n = 108); NIF(-)/DM(+) (n = 64); and NIF(+)/DM(+) (n = 51). The periodontal conditions in anterior teeth were assessed using plaque index, sulcus bleeding index, clinical attachment loss (AL), probing depth (PD), and the number of missing teeth. Results: Using analysis of covariance, NIF intake was associated with mean PD and extent of PD ≥4 mm in the non-DM and DM groups. The subjects in the NIF(+)/DM(+) subgroup showed greater mean AL and percentage of sites with AL ≥5 mm and AL ≥7 mm than those in NIF(-)/DM(+) subgroup, whereas no significant difference existed between subjects in NIF(-)/DM(-) and NIF(+)/DM(-) subgroups. The NIF(+)/DM(+) subgroup exhibited a greater percentage of sites with AL ≥5 mm (35.5%) compared to the other three subgroups (24.7% for NIF[-]/DM[-], P = 0.004; 25.0% for NIF[+]/DM[-], P = 0.007; and 25.2% for NIF[-]/DM[+], P = 0.016). Logistic regression analysis showed that the NIF(+)/DM(+) subgroup had a significantly higher risk for having 7gt;10% of sites with AL ≥5 mm compared to the NIF(-)/DM(-) subgroup (odds ratio [OR] = 2.9; 95% confidence interval [CI]: 1.2 to 7.4; P = 0.022), the NIF(+)/DM(-) subgroup (OR = 3.1; 95% CI: 1.2 to 8.1; P = 0.020), and the NIF(-)/DM(+) subgroup (OR = 5.1; CI: 1.8 to 14.3; P = 0.002). Conclusion: NIF intake may increase the risk for periodontal destruction in patients with type 2 DM.en_HK
dc.languageengen_HK
dc.publisherAmerican Academy of Periodontology. The Journal's web site is located at http://www.perio.orgen_HK
dc.relation.ispartofJournal of Periodontologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshCalcium Channel Blockers - adverse effects - therapeutic useen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshDiabetes Mellitus, Type 2 - complicationsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - complications - drug therapyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNifedipine - adverse effects - therapeutic useen_HK
dc.subject.meshPeriodontal Diseases - chemically induced - complicationsen_HK
dc.subject.meshPeriodontal Indexen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSeverity of Illness Indexen_HK
dc.subject.meshSingle-Blind Methoden_HK
dc.titleNifedipine intake increases the risk for periodontal destruction in subjects with type 2 diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3492&volume=79&spage=2054&epage=2059&date=2008&atitle=Nifedipine+intake+increases+the+risk+for+periodontal+destruction+in+subjects+with+type+2+diabetes+mellitusen_HK
dc.identifier.emailJin, L:ljjin@hkucc.hku.hken_HK
dc.identifier.authorityJin, L=rp00028en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1902/jop.2008.080033en_HK
dc.identifier.pmid18980513-
dc.identifier.scopuseid_2-s2.0-55749101608en_HK
dc.identifier.hkuros154123en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-55749101608&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume79en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2054en_HK
dc.identifier.epage2059en_HK
dc.identifier.isiWOS:000260933900009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, X=36014295300en_HK
dc.identifier.scopusauthoridLuan, Q=14625404700en_HK
dc.identifier.scopusauthoridWang, X=8885333800en_HK
dc.identifier.scopusauthoridSha, Y=7102249983en_HK
dc.identifier.scopusauthoridHe, L=7403374572en_HK
dc.identifier.scopusauthoridCao, C=7401501946en_HK
dc.identifier.scopusauthoridJin, L=7403328850en_HK

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