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Article: A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region

TitleA clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region
Authors
Keywordsbasaloid squamous cell carcinoma
diagnosis
head and neck
immunohistochemistry
oral mucosa
pathology
prognosis
squamous cell carcinoma
Issue Date2008
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijom
Citation
International Journal Of Oral And Maxillofacial Surgery, 2008, v. 37 n. 11, p. 1003-1008 How to Cite?
AbstractBasaloid squamous cell carcinoma (BSCC) is a rare distinct variant of squamous cell carcinoma (SCC). To investigate its clinical behavior and prognosis, 15 patients with BSCC in the oral and maxillofacial region were clinically analyzed and compared with 15 patients with conventional SCC matched for site, stage, gender and age. To understand its immunohistochemical features, sections for cytokeratin AE1/AE3, CK 13. CK 7, CK 8, proliferating cell nuclear antigen (PCNA) and p53 were reviewed from 12 patients with BSCC. The rate of cervical lymph node metastasis of BSCC was as high as 67% and that of distant metastasis 13%. The tumor recurrence rate was 33% and the 3-year and 5-year survival rates were 53% and 32%, respectively. For conventional SCC, the cervical lymph node metastasis rate was 27%, that of distant metastasis 7%, tumor recurrence rate was 33%, and 3-year and 5-year survival rates were 80% and 70%, respectively. In most BSCC patients (10/12) the PCNA index was over 50%. Twelve BSCC patients were diagnosed with grade II or III conventional SCC when the original records of the primary diagnosis for the 15 patients with BSCC were reviewed. The biological behavior and prognosis of BSCC are similar to those of poorly differentiated SCC. © 2008 International Association of Oral and Maxillofacial Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/58097
ISSN
2015 Impact Factor: 1.563
2015 SCImago Journal Rankings: 0.854
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, GYen_HK
dc.contributor.authorGao, Yen_HK
dc.contributor.authorPeng, Xen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorZhao, FYen_HK
dc.contributor.authorWu, MJen_HK
dc.date.accessioned2010-05-31T03:23:45Z-
dc.date.available2010-05-31T03:23:45Z-
dc.date.issued2008en_HK
dc.identifier.citationInternational Journal Of Oral And Maxillofacial Surgery, 2008, v. 37 n. 11, p. 1003-1008en_HK
dc.identifier.issn0901-5027en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58097-
dc.description.abstractBasaloid squamous cell carcinoma (BSCC) is a rare distinct variant of squamous cell carcinoma (SCC). To investigate its clinical behavior and prognosis, 15 patients with BSCC in the oral and maxillofacial region were clinically analyzed and compared with 15 patients with conventional SCC matched for site, stage, gender and age. To understand its immunohistochemical features, sections for cytokeratin AE1/AE3, CK 13. CK 7, CK 8, proliferating cell nuclear antigen (PCNA) and p53 were reviewed from 12 patients with BSCC. The rate of cervical lymph node metastasis of BSCC was as high as 67% and that of distant metastasis 13%. The tumor recurrence rate was 33% and the 3-year and 5-year survival rates were 53% and 32%, respectively. For conventional SCC, the cervical lymph node metastasis rate was 27%, that of distant metastasis 7%, tumor recurrence rate was 33%, and 3-year and 5-year survival rates were 80% and 70%, respectively. In most BSCC patients (10/12) the PCNA index was over 50%. Twelve BSCC patients were diagnosed with grade II or III conventional SCC when the original records of the primary diagnosis for the 15 patients with BSCC were reviewed. The biological behavior and prognosis of BSCC are similar to those of poorly differentiated SCC. © 2008 International Association of Oral and Maxillofacial Surgeons.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijomen_HK
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgeryen_HK
dc.subjectbasaloid squamous cell carcinomaen_HK
dc.subjectdiagnosisen_HK
dc.subjecthead and necken_HK
dc.subjectimmunohistochemistryen_HK
dc.subjectoral mucosaen_HK
dc.subjectpathologyen_HK
dc.subjectprognosisen_HK
dc.subjectsquamous cell carcinomaen_HK
dc.titleA clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial regionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0901-5027&volume=37&spage=1003&epage=1008&date=2008&atitle=A+clinicopathologic+study+on+basaloid+squamous+cell+carcinoma+in+the+oral+and+maxillofacial+regionen_HK
dc.identifier.emailPeng, X: pengxin@hku.hken_HK
dc.identifier.authorityPeng, X=rp01370en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijom.2008.05.019en_HK
dc.identifier.pmid18632253-
dc.identifier.scopuseid_2-s2.0-55249088503en_HK
dc.identifier.hkuros156862en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-55249088503&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1003en_HK
dc.identifier.epage1008en_HK
dc.identifier.isiWOS:000261328000005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYu, GY=7403528875en_HK
dc.identifier.scopusauthoridGao, Y=34770473800en_HK
dc.identifier.scopusauthoridPeng, X=35270121900en_HK
dc.identifier.scopusauthoridChen, Y=24437774700en_HK
dc.identifier.scopusauthoridZhao, FY=7402048563en_HK
dc.identifier.scopusauthoridWu, MJ=8377053300en_HK

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