File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of quercetin on bone formation

TitleEffect of quercetin on bone formation
Authors
KeywordsBone repair
Flavonol
Phytoestrogen
Quercetin
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres
Citation
Journal Of Orthopaedic Research, 2008, v. 26 n. 8, p. 1061-1066 How to Cite?
AbstractQuercetin is a flavonol, also a phytoestrogen, available commonly in onions and apples. Our laboratory compared the amount of new bone produced by quercetin in a collagen matrix to that produced by bone grafts and a collagen matrix. Eighteen bone defects, 5 × 10 mm were created in the parietal bone of nine New Zealand White rabbits. In the experimental group, six defects were grafted with quercetin solution mixed with a collagen matrix. In the control groups, six defects were grafted with a collagen matrix alone (active control) and six were left empty (passive control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Serial sections were cut across each defect. Quantitative analysis of new bone formation was made on 100 sections (50 sections for each group) using image analysis. A total of 556% more new bone was present in defects grafted with quercetin in a collagen matrix than those grafted with a collagen matrix alone. No bone was formed in the passive control group. In conclusion, quercetin in a collagen matrix has the effect of increasing new bone formation locally, and can be used as a bone graft material. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/58070
ISSN
2015 Impact Factor: 2.807
2015 SCImago Journal Rankings: 1.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-05-31T03:23:18Z-
dc.date.available2010-05-31T03:23:18Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Orthopaedic Research, 2008, v. 26 n. 8, p. 1061-1066en_HK
dc.identifier.issn0736-0266en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58070-
dc.description.abstractQuercetin is a flavonol, also a phytoestrogen, available commonly in onions and apples. Our laboratory compared the amount of new bone produced by quercetin in a collagen matrix to that produced by bone grafts and a collagen matrix. Eighteen bone defects, 5 × 10 mm were created in the parietal bone of nine New Zealand White rabbits. In the experimental group, six defects were grafted with quercetin solution mixed with a collagen matrix. In the control groups, six defects were grafted with a collagen matrix alone (active control) and six were left empty (passive control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Serial sections were cut across each defect. Quantitative analysis of new bone formation was made on 100 sections (50 sections for each group) using image analysis. A total of 556% more new bone was present in defects grafted with quercetin in a collagen matrix than those grafted with a collagen matrix alone. No bone was formed in the passive control group. In conclusion, quercetin in a collagen matrix has the effect of increasing new bone formation locally, and can be used as a bone graft material. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthresen_HK
dc.relation.ispartofJournal of Orthopaedic Researchen_HK
dc.rightsJournal of Orthopaedic Research . Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectBone repairen_HK
dc.subjectFlavonolen_HK
dc.subjectPhytoestrogenen_HK
dc.subjectQuercetinen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntioxidants - chemistry - pharmacologyen_HK
dc.subject.meshBone Diseases - drug therapy - pathologyen_HK
dc.subject.meshBone Regeneration - drug effectsen_HK
dc.subject.meshCollagen - pharmacologyen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshQuercetin - chemistry - pharmacologyen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshSkull - drug effects - pathologyen_HK
dc.titleEffect of quercetin on bone formationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0736-0266&volume=&spage=1061&epage=1066&date=2008&atitle=Effect+of+Quercetin+on+Bone+Formationen_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jor.20638en_HK
dc.identifier.pmid18383168-
dc.identifier.scopuseid_2-s2.0-49149126753en_HK
dc.identifier.hkuros148730en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-49149126753&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1061en_HK
dc.identifier.epage1066en_HK
dc.identifier.isiWOS:000257714100004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats