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Article: Cementum attachment protein/protein-tyrosine phosphotase-like member A is not expressed in teeth

TitleCementum attachment protein/protein-tyrosine phosphotase-like member A is not expressed in teeth
Authors
Issue Date2009
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htm
Citation
International Journal Of Molecular Medicine, 2009, v. 23 n. 2, p. 293-296 How to Cite?
AbstractCementum is a highly specialized connective tissue that covers tooth roots. The only cementum-specific protein described to date is the cementum attachment protein (CAP). A putative sequence for CAP was established from a cDNA clone isolated from a human cementifying fibroma cDNA library. This sequence overlaps with a phosphatase-like protein in muscle termed the protein-tyrosine phosphatase-like member A (PTPLA). To clarify the nature of CAP/PTPLA, we cloned the homologous rat protein and determined its sequence. The rat protein shared 94% sequence identity with the human protein. On Northern blots containing RNA from various rat tissues of different developmental stages, the cDNA hybridized to an mRNA expressed in heart and skeletal muscle but not in teeth. These results were confirmed by real-time PCR. Thus, the sequence deposited in public databanks under the name 'cementum attachment protein' does not represent genuine CAP.
Persistent Identifierhttp://hdl.handle.net/10722/58066
ISSN
2015 Impact Factor: 2.348
2015 SCImago Journal Rankings: 0.868
ISI Accession Number ID
Funding AgencyGrant Number
ITI Foundation382/2005
Foundation for Clinical Research
Funding Information:

This study was supported by grants from the ITI Foundation (382/2005) and the Foundation for Clinical Research at the University of Bern.

References

 

DC FieldValueLanguage
dc.contributor.authorSchild, Cen_HK
dc.contributor.authorBeyeler, Men_HK
dc.contributor.authorLang, NPen_HK
dc.contributor.authorTrueb, Ben_HK
dc.date.accessioned2010-05-31T03:23:14Z-
dc.date.available2010-05-31T03:23:14Z-
dc.date.issued2009en_HK
dc.identifier.citationInternational Journal Of Molecular Medicine, 2009, v. 23 n. 2, p. 293-296en_HK
dc.identifier.issn1107-3756en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58066-
dc.description.abstractCementum is a highly specialized connective tissue that covers tooth roots. The only cementum-specific protein described to date is the cementum attachment protein (CAP). A putative sequence for CAP was established from a cDNA clone isolated from a human cementifying fibroma cDNA library. This sequence overlaps with a phosphatase-like protein in muscle termed the protein-tyrosine phosphatase-like member A (PTPLA). To clarify the nature of CAP/PTPLA, we cloned the homologous rat protein and determined its sequence. The rat protein shared 94% sequence identity with the human protein. On Northern blots containing RNA from various rat tissues of different developmental stages, the cDNA hybridized to an mRNA expressed in heart and skeletal muscle but not in teeth. These results were confirmed by real-time PCR. Thus, the sequence deposited in public databanks under the name 'cementum attachment protein' does not represent genuine CAP.en_HK
dc.languageengen_HK
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htmen_HK
dc.relation.ispartofInternational Journal of Molecular Medicineen_HK
dc.subject.meshAmino Acid Sequenceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Adhesion Molecules - genetics - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshModels, Geneticen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshProtein Tyrosine Phosphatases - genetics - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshSequence Alignmenten_HK
dc.subject.meshTooth - metabolismen_HK
dc.titleCementum attachment protein/protein-tyrosine phosphotase-like member A is not expressed in teethen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1107-3756&volume=23&spage=293&epage=296&date=2009&atitle=Cementum+attachment+protein/protein-tyrosine+phosphotase-like+member+A+is+not+expressed+in+teethen_HK
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_HK
dc.identifier.authorityLang, NP=rp00031en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3892/ijmm_00000130en_HK
dc.identifier.pmid19148556-
dc.identifier.scopuseid_2-s2.0-64749110888en_HK
dc.identifier.hkuros165544en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64749110888&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue2en_HK
dc.identifier.spage293en_HK
dc.identifier.epage296en_HK
dc.identifier.isiWOS:000262571500021-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridSchild, C=36878498900en_HK
dc.identifier.scopusauthoridBeyeler, M=14122904900en_HK
dc.identifier.scopusauthoridLang, NP=7201577367en_HK
dc.identifier.scopusauthoridTrueb, B=7006783821en_HK

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