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Article: Identification of the chondrogenic pathway in the mandibular condylar cartilage

TitleIdentification of the chondrogenic pathway in the mandibular condylar cartilage
Authors
KeywordsCartilage
CHAD
Condyles
CryAB
Mechanical
Microarray
Mustang
Noggin
NOV
Real time RT-PCR
Stress
Issue Date2009
PublisherFrontiers in Bioscience
Citation
Frontiers In Bioscience, 2009, v. 14 n. 5, p. 1932-1938 How to Cite?
AbstractTo identify genetic expression of mandibular condylar cartilage during natural growth and under mechanical strain as a result of mandibular advancement. One hundred and forty four 35 days old female Sprague-Dawley rats were sacrificed on 8 different experimental days. Total RNA was extracted for oligonucleotide microarray gene chips containing 15,923 transcripts. Sixteen genes representing the chondrogenesis pathway were identified. Five of them were novel and have never been identified in mandibular condyles before. Quantitative analysis using real-time PCR revealed that these genes were involved in different stages in chondrogenesis and played an important role in condylar growth.
Persistent Identifierhttp://hdl.handle.net/10722/58044
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSong, Yen_HK
dc.contributor.authorWu, Cen_HK
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorMRabie, ABen_HK
dc.date.accessioned2010-05-31T03:22:52Z-
dc.date.available2010-05-31T03:22:52Z-
dc.date.issued2009en_HK
dc.identifier.citationFrontiers In Bioscience, 2009, v. 14 n. 5, p. 1932-1938en_HK
dc.identifier.issn1093-9946en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58044-
dc.description.abstractTo identify genetic expression of mandibular condylar cartilage during natural growth and under mechanical strain as a result of mandibular advancement. One hundred and forty four 35 days old female Sprague-Dawley rats were sacrificed on 8 different experimental days. Total RNA was extracted for oligonucleotide microarray gene chips containing 15,923 transcripts. Sixteen genes representing the chondrogenesis pathway were identified. Five of them were novel and have never been identified in mandibular condyles before. Quantitative analysis using real-time PCR revealed that these genes were involved in different stages in chondrogenesis and played an important role in condylar growth.en_HK
dc.languageengen_HK
dc.publisherFrontiers in Bioscienceen_HK
dc.relation.ispartofFrontiers in Bioscienceen_HK
dc.subjectCartilageen_HK
dc.subjectCHADen_HK
dc.subjectCondylesen_HK
dc.subjectCryABen_HK
dc.subjectMechanicalen_HK
dc.subjectMicroarrayen_HK
dc.subjectMustangen_HK
dc.subjectNogginen_HK
dc.subjectNOVen_HK
dc.subjectReal time RT-PCRen_HK
dc.subjectStressen_HK
dc.titleIdentification of the chondrogenic pathway in the mandibular condylar cartilageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1093-9946&volume=14&spage=1932&epage=1938&date=2009&atitle=Identification+of+the+Chondrogenic+Pathway+in+the+Mandibular+Condylar+Cartilageen_HK
dc.identifier.emailWong, RWK:fyoung@hkucc.hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2741/3352en_HK
dc.identifier.pmid19273174-
dc.identifier.scopuseid_2-s2.0-63849196687en_HK
dc.identifier.hkuros154878en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-63849196687&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1932en_HK
dc.identifier.epage1938en_HK
dc.identifier.isiWOS:000262352400125-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSong, Y=26430173700en_HK
dc.identifier.scopusauthoridWu, C=7501667713en_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridMRabie, AB=31967821200en_HK

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