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Article: Solubility of strontium-substituted apatite by solid titration
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TitleSolubility of strontium-substituted apatite by solid titration
 
AuthorsPan, HB1
Li, ZY1
Lam, WM1
Wong, JC1
Darvell, BW1
Luk, KDK1
Lu, WW1
 
KeywordsHydroxyapatite
Solid titration
Solubility
Strontium-substituted apatite
 
Issue Date2009
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
 
CitationActa Biomaterialia, 2009, v. 5 n. 5, p. 1678-1685 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.actbio.2008.11.032
 
AbstractSolid titration was used to explore the solubility isotherms of partially (Srx-HAp, x = 1, 5, 10, 40, 60 mol.%) and fully substituted strontium hydroxyapatite (Sr-HAp). Solubility increased with increasing strontium content. No phase other than strontium-substituted HAp, corresponding to the original titrant, was detected in the solid present at equilibrium; in particular, dicalcium hydrogen phosphate was not detected at low pH. The increase in solubility with strontium content is interpreted as a destabilization of the crystal structure by the larger strontium ion. Carbonated HAp was formed in simulated body fluid containing carbonate on seeding with Sr10-HAp, but the precipitate was strontium-substituted on seeding with Sr-HAp. Strontium-substituted HAp might be usable as a template for the growth of new bone, since nucleation appears to be facilitated. © 2008 Acta Materialia Inc.
 
ISSN1742-7061
2012 Impact Factor: 5.093
2012 SCImago Journal Rankings: 1.614
 
DOIhttp://dx.doi.org/10.1016/j.actbio.2008.11.032
 
ISI Accession Number IDWOS:000266506800031
Funding AgencyGrant Number
Hong Kong ITFGHP/009/06
HKRGCHKU7147/07E
Funding Information:

This study was supported by Hong Kong ITF GHP/009/06 and HKRGC (HKU7147/07E). The authors thank Frankie Chan for his assistance in TEM analysis and Guofeng Chen for XRD analysis.

 
ReferencesReferences in Scopus
 
GrantsOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications
 
DC FieldValue
dc.contributor.authorPan, HB
 
dc.contributor.authorLi, ZY
 
dc.contributor.authorLam, WM
 
dc.contributor.authorWong, JC
 
dc.contributor.authorDarvell, BW
 
dc.contributor.authorLuk, KDK
 
dc.contributor.authorLu, WW
 
dc.date.accessioned2010-05-31T03:22:34Z
 
dc.date.available2010-05-31T03:22:34Z
 
dc.date.issued2009
 
dc.description.abstractSolid titration was used to explore the solubility isotherms of partially (Srx-HAp, x = 1, 5, 10, 40, 60 mol.%) and fully substituted strontium hydroxyapatite (Sr-HAp). Solubility increased with increasing strontium content. No phase other than strontium-substituted HAp, corresponding to the original titrant, was detected in the solid present at equilibrium; in particular, dicalcium hydrogen phosphate was not detected at low pH. The increase in solubility with strontium content is interpreted as a destabilization of the crystal structure by the larger strontium ion. Carbonated HAp was formed in simulated body fluid containing carbonate on seeding with Sr10-HAp, but the precipitate was strontium-substituted on seeding with Sr-HAp. Strontium-substituted HAp might be usable as a template for the growth of new bone, since nucleation appears to be facilitated. © 2008 Acta Materialia Inc.
 
dc.description.naturepostprint
 
dc.identifier.citationActa Biomaterialia, 2009, v. 5 n. 5, p. 1678-1685 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.actbio.2008.11.032
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.actbio.2008.11.032
 
dc.identifier.eissn1878-7568
 
dc.identifier.epage1685
 
dc.identifier.hkuros163518
 
dc.identifier.isiWOS:000266506800031
Funding AgencyGrant Number
Hong Kong ITFGHP/009/06
HKRGCHKU7147/07E
Funding Information:

This study was supported by Hong Kong ITF GHP/009/06 and HKRGC (HKU7147/07E). The authors thank Frankie Chan for his assistance in TEM analysis and Guofeng Chen for XRD analysis.

 
dc.identifier.issn1742-7061
2012 Impact Factor: 5.093
2012 SCImago Journal Rankings: 1.614
 
dc.identifier.issue5
 
dc.identifier.openurl
 
dc.identifier.pmid19135423
 
dc.identifier.scopuseid_2-s2.0-67349159702
 
dc.identifier.spage1678
 
dc.identifier.urihttp://hdl.handle.net/10722/58026
 
dc.identifier.volume5
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofActa Biomaterialia
 
dc.relation.projectOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications
 
dc.relation.referencesReferences in Scopus
 
dc.rightsActa Biomaterialia. Copyright © Elsevier BV.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshBody Fluids
 
dc.subject.meshCalcium - chemistry
 
dc.subject.meshHydroxyapatites - chemistry
 
dc.subject.meshStrontium - chemistry
 
dc.subject.meshTitrimetry - methods
 
dc.subjectHydroxyapatite
 
dc.subjectSolid titration
 
dc.subjectSolubility
 
dc.subjectStrontium-substituted apatite
 
dc.titleSolubility of strontium-substituted apatite by solid titration
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong