Article: Solubility of strontium-substituted apatite by solid titration
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- Publisher Website: 10.1016/j.actbio.2008.11.032
- Scopus: eid_2-s2.0-67349159702
- PMID: 19135423
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| Title | Solubility of strontium-substituted apatite by solid titration | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Pan, HB1 Li, ZY1 Lam, WM1 Wong, JC1 Darvell, BW1 Luk, KDK1 Lu, WW1 | ||||||
| Keywords | Hydroxyapatite Solid titration Solubility Strontium-substituted apatite | ||||||
| Issue Date | 2009 | ||||||
| Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat | ||||||
| Citation | Acta Biomaterialia, 2009, v. 5 n. 5, p. 1678-1685 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.actbio.2008.11.032 | ||||||
| Abstract | Solid titration was used to explore the solubility isotherms of partially (Srx-HAp, x = 1, 5, 10, 40, 60 mol.%) and fully substituted strontium hydroxyapatite (Sr-HAp). Solubility increased with increasing strontium content. No phase other than strontium-substituted HAp, corresponding to the original titrant, was detected in the solid present at equilibrium; in particular, dicalcium hydrogen phosphate was not detected at low pH. The increase in solubility with strontium content is interpreted as a destabilization of the crystal structure by the larger strontium ion. Carbonated HAp was formed in simulated body fluid containing carbonate on seeding with Sr10-HAp, but the precipitate was strontium-substituted on seeding with Sr-HAp. Strontium-substituted HAp might be usable as a template for the growth of new bone, since nucleation appears to be facilitated. © 2008 Acta Materialia Inc. | ||||||
| ISSN | 1742-7061 2011 Impact Factor: 4.865 2011 SCImago Journal Rankings: 0.285 | ||||||
| DOI | http://dx.doi.org/10.1016/j.actbio.2008.11.032 | ||||||
| ISI Accession Number ID | WOS:000266506800031
Funding Information: This study was supported by Hong Kong ITF GHP/009/06 and HKRGC (HKU7147/07E). The authors thank Frankie Chan for his assistance in TEM analysis and Guofeng Chen for XRD analysis. | ||||||
| References | References in Scopus | ||||||
| Grants | Optimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications |
| dc.contributor.author | Pan, HB | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Li, ZY | ||||||
| dc.contributor.author | Lam, WM | ||||||
| dc.contributor.author | Wong, JC | ||||||
| dc.contributor.author | Darvell, BW | ||||||
| dc.contributor.author | Luk, KDK | ||||||
| dc.contributor.author | Lu, WW | ||||||
| dc.date.accessioned | 2010-05-31T03:22:34Z | ||||||
| dc.date.available | 2010-05-31T03:22:34Z | ||||||
| dc.date.issued | 2009 | ||||||
| dc.description.abstract | Solid titration was used to explore the solubility isotherms of partially (Srx-HAp, x = 1, 5, 10, 40, 60 mol.%) and fully substituted strontium hydroxyapatite (Sr-HAp). Solubility increased with increasing strontium content. No phase other than strontium-substituted HAp, corresponding to the original titrant, was detected in the solid present at equilibrium; in particular, dicalcium hydrogen phosphate was not detected at low pH. The increase in solubility with strontium content is interpreted as a destabilization of the crystal structure by the larger strontium ion. Carbonated HAp was formed in simulated body fluid containing carbonate on seeding with Sr10-HAp, but the precipitate was strontium-substituted on seeding with Sr-HAp. Strontium-substituted HAp might be usable as a template for the growth of new bone, since nucleation appears to be facilitated. © 2008 Acta Materialia Inc. | ||||||
| dc.description.grant | Optimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications | ||||||
| dc.description.grantcode | 96197 | ||||||
| dc.description.nature | postprint | ||||||
| dc.identifier.citation | Acta Biomaterialia, 2009, v. 5 n. 5, p. 1678-1685 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.actbio.2008.11.032 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.actbio.2008.11.032 | ||||||
| dc.identifier.epage | 1685 | ||||||
| dc.identifier.hkuros | 163518 | ||||||
| dc.identifier.isi | WOS:000266506800031
Funding Information: This study was supported by Hong Kong ITF GHP/009/06 and HKRGC (HKU7147/07E). The authors thank Frankie Chan for his assistance in TEM analysis and Guofeng Chen for XRD analysis. | ||||||
| dc.identifier.issn | 1742-7061 2011 Impact Factor: 4.865 2011 SCImago Journal Rankings: 0.285 | ||||||
| dc.identifier.issue | 5 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 19135423 | ||||||
| dc.identifier.scopus | eid_2-s2.0-67349159702 | ||||||
| dc.identifier.spage | 1678 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/58026 | ||||||
| dc.identifier.volume | 5 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat | ||||||
| dc.publisher.place | Netherlands | ||||||
| dc.relation.ispartof | Acta Biomaterialia | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | Acta Biomaterialia. Copyright © Elsevier BV. | ||||||
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License | ||||||
| dc.subject.mesh | Body Fluids | ||||||
| dc.subject.mesh | Calcium - chemistry | ||||||
| dc.subject.mesh | Hydroxyapatites - chemistry | ||||||
| dc.subject.mesh | Strontium - chemistry | ||||||
| dc.subject.mesh | Titrimetry - methods | ||||||
| dc.subject | Hydroxyapatite | ||||||
| dc.subject | Solid titration | ||||||
| dc.subject | Solubility | ||||||
| dc.subject | Strontium-substituted apatite | ||||||
| dc.title | Solubility of strontium-substituted apatite by solid titration | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong