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Article: The molecular markers for condylar growth: Experimental and clinical implications

TitleThe molecular markers for condylar growth: Experimental and clinical implications
Authors
KeywordsCondylar growth
Functional appliance
Mandibular advancement
Issue Date2009
PublisherElsevier BV
Citation
Orthodontic Waves, 2009, v. 68 n. 2, p. 51-56 How to Cite?
AbstractThe outpour of new research has led to the identification of several factors that play an important role in condylar growth. The objectives of this review are to present the molecular markers that regulate the growth of different cells in the mandibular condyle and their impact on clinical use of functional appliance. The proliferative layer in the mandibular condyle houses a great number of undifferentiated mesenchymal cells that provide the pool of chondrogenic cells. Therefore, it is important to understand the factors that regulate the cell cycle of these replicating mesenchymal cells as well as the factors that control their differentiation to chondroblasts. These chondroblasts in turn are engaged in cartilage matrix synthesis. Therefore, it is critical to present the factors that regulate matrix formation. The process of maturation of chondrocytes into hypertrophic chondrocytes directly impacts the number of cell replication cycles and indirectly affects growth. Therefore, it is of great importance to review the factors that regulate chondrocytes maturation. Hypertrophic chondrocytes secrete hypertrophic matrix with its type X collagen that marks the onset of endochondral ossification. Angiogenesis is regulated by vascular endothelial growth factor (VEGF), and the new blood vessels are rich depository of mesenchymal cells. Factors that regulate the differentiation of these cells into osteogenic cells are critical to growth of the condyle. Understanding of these markers and their levels of expression provides the basis for application of different treatment modalities in the area of growth modification. Furthermore, the identification of factors critical to condylar growth provides us with candidate genes for future gene therapy. © 2009 Elsevier Ltd and the Japanese Orthodontic Society.
Persistent Identifierhttp://hdl.handle.net/10722/58018
ISSN
2015 SCImago Journal Rankings: 0.148
References

 

DC FieldValueLanguage
dc.contributor.authorAlkalaly, AAen_HK
dc.contributor.authorLeung, FYCen_HK
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-05-31T03:22:26Z-
dc.date.available2010-05-31T03:22:26Z-
dc.date.issued2009en_HK
dc.identifier.citationOrthodontic Waves, 2009, v. 68 n. 2, p. 51-56en_HK
dc.identifier.issn1344-0241en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58018-
dc.description.abstractThe outpour of new research has led to the identification of several factors that play an important role in condylar growth. The objectives of this review are to present the molecular markers that regulate the growth of different cells in the mandibular condyle and their impact on clinical use of functional appliance. The proliferative layer in the mandibular condyle houses a great number of undifferentiated mesenchymal cells that provide the pool of chondrogenic cells. Therefore, it is important to understand the factors that regulate the cell cycle of these replicating mesenchymal cells as well as the factors that control their differentiation to chondroblasts. These chondroblasts in turn are engaged in cartilage matrix synthesis. Therefore, it is critical to present the factors that regulate matrix formation. The process of maturation of chondrocytes into hypertrophic chondrocytes directly impacts the number of cell replication cycles and indirectly affects growth. Therefore, it is of great importance to review the factors that regulate chondrocytes maturation. Hypertrophic chondrocytes secrete hypertrophic matrix with its type X collagen that marks the onset of endochondral ossification. Angiogenesis is regulated by vascular endothelial growth factor (VEGF), and the new blood vessels are rich depository of mesenchymal cells. Factors that regulate the differentiation of these cells into osteogenic cells are critical to growth of the condyle. Understanding of these markers and their levels of expression provides the basis for application of different treatment modalities in the area of growth modification. Furthermore, the identification of factors critical to condylar growth provides us with candidate genes for future gene therapy. © 2009 Elsevier Ltd and the Japanese Orthodontic Society.en_HK
dc.languageengen_HK
dc.publisherElsevier BVen_HK
dc.relation.ispartofOrthodontic Wavesen_HK
dc.rightsOrthodontic Waves . Copyright © Elsevier BV.en_HK
dc.subjectCondylar growthen_HK
dc.subjectFunctional applianceen_HK
dc.subjectMandibular advancementen_HK
dc.titleThe molecular markers for condylar growth: Experimental and clinical implicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1344-0241&volume=68&spage=51&epage=56&date=2009&atitle=The+molecular+markers+for+condylar+growth:+Experimental+and+clinical+implicationsen_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.odw.2008.11.004en_HK
dc.identifier.scopuseid_2-s2.0-65049091606en_HK
dc.identifier.hkuros155536en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65049091606&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume68en_HK
dc.identifier.issue2en_HK
dc.identifier.spage51en_HK
dc.identifier.epage56en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridAlkalaly, AA=24922819100en_HK
dc.identifier.scopusauthoridLeung, FYC=36103875400en_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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