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Article: Community lifestyle of Candida in mixed biofilms: A mini review

TitleCommunity lifestyle of Candida in mixed biofilms: A mini review
Authors
Issue Date2009
PublisherWiley-Blackwell Verlag GmbH. The Journal's web site is located at http://www.blackwellpublishing.com/journals/MYC
Citation
Mycoses, 2009, v. 52 n. 6, p. 467-475 How to Cite?
AbstractCandida is the most common human fungal pathogen that causes a variety of afflictions from superficial mucosal infections to deep mycoses. Biofilm formation is a major virulence factor of Candida, and more than 300 articles have been published on Candida biofilms over the past two decades. However, most of these data are on monospecies biofilms of Candida, and information on mixed-species Candida biofilms or bacteria-Candida combinations is still scarce. Yet, in nature, the yeast exist in a mixed milieu either in the oral cavity or in other habitats with a multitude of bacteria colonising mucosal surfaces within a shared community. This mini review describes the current knowledge on candidal-candidal or bacterial-candidal interactions in mixed-species biofilms. The underlying mechanisms of these interactions appear to depend on several factors relating to biofilm development, such as species and strains of organisms, nutritional factors, aerobiosis and related environmental factors. Although the fundamental nature of these interactions appears to be commensalism and antagonism, the emerging evidence based on novel molecular, proteomic and imaging tools indicates these biological mechanisms to be far more complex than hitherto recognised. Demystifying the mechanisms underlying the growth and development of mixed-species communities involving Candida will undoubtedly yield useful data for the effective management of microbial infections in general. © 2009 Blackwell Verlag GmbH.
Persistent Identifierhttp://hdl.handle.net/10722/58013
ISSN
2015 Impact Factor: 2.332
2015 SCImago Journal Rankings: 0.921
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of the Hong Kong SAR, China (CERG)HKU 7624/06M
Funding Information:

Some of the unpublished studies quoted in this review were supported by a grant from the Research Grants Council of the Hong Kong SAR, China (CERG Grant No. HKU 7624/06M of LPS).

References
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DC FieldValueLanguage
dc.contributor.authorThein, ZMen_HK
dc.contributor.authorSeneviratne, CJen_HK
dc.contributor.authorSamaranayake, YHen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-05-31T03:22:21Z-
dc.date.available2010-05-31T03:22:21Z-
dc.date.issued2009en_HK
dc.identifier.citationMycoses, 2009, v. 52 n. 6, p. 467-475en_HK
dc.identifier.issn0933-7407en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58013-
dc.description.abstractCandida is the most common human fungal pathogen that causes a variety of afflictions from superficial mucosal infections to deep mycoses. Biofilm formation is a major virulence factor of Candida, and more than 300 articles have been published on Candida biofilms over the past two decades. However, most of these data are on monospecies biofilms of Candida, and information on mixed-species Candida biofilms or bacteria-Candida combinations is still scarce. Yet, in nature, the yeast exist in a mixed milieu either in the oral cavity or in other habitats with a multitude of bacteria colonising mucosal surfaces within a shared community. This mini review describes the current knowledge on candidal-candidal or bacterial-candidal interactions in mixed-species biofilms. The underlying mechanisms of these interactions appear to depend on several factors relating to biofilm development, such as species and strains of organisms, nutritional factors, aerobiosis and related environmental factors. Although the fundamental nature of these interactions appears to be commensalism and antagonism, the emerging evidence based on novel molecular, proteomic and imaging tools indicates these biological mechanisms to be far more complex than hitherto recognised. Demystifying the mechanisms underlying the growth and development of mixed-species communities involving Candida will undoubtedly yield useful data for the effective management of microbial infections in general. © 2009 Blackwell Verlag GmbH.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Verlag GmbH. The Journal's web site is located at http://www.blackwellpublishing.com/journals/MYCen_HK
dc.relation.ispartofMycosesen_HK
dc.subject.meshBacteria - growth & developmenten_HK
dc.subject.meshBiofilmsen_HK
dc.subject.meshCandida - growth & development - physiologyen_HK
dc.subject.meshHumansen_HK
dc.titleCommunity lifestyle of Candida in mixed biofilms: A mini reviewen_HK
dc.typeArticleen_HK
dc.identifier.emailSeneviratne, CJ:jaya@hku.hken_HK
dc.identifier.emailSamaranayake, YH:hema@hkucc.hku.hken_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySeneviratne, CJ=rp01372en_HK
dc.identifier.authoritySamaranayake, YH=rp00025en_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1439-0507.2009.01719.xen_HK
dc.identifier.pmid19486299-
dc.identifier.scopuseid_2-s2.0-70350675434en_HK
dc.identifier.hkuros158849en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350675434&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue6en_HK
dc.identifier.spage467en_HK
dc.identifier.epage475en_HK
dc.identifier.isiWOS:000270589000001-
dc.publisher.placeGermanyen_HK
dc.relation.projectCandida biofilms: molecular mechanisms and clinical implications-
dc.identifier.scopusauthoridThein, ZM=14049367300en_HK
dc.identifier.scopusauthoridSeneviratne, CJ=6701897753en_HK
dc.identifier.scopusauthoridSamaranayake, YH=6602677237en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.citeulike5927212-

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