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Article: Effect of daidzein on bone formation

TitleEffect of daidzein on bone formation
Authors
KeywordsBone graft
Bone repair
Daidzein
Issue Date2009
PublisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/
Citation
Frontiers In Bioscience, 2009, v. 14 n. 10, p. 3673-3679 How to Cite?
AbstractThe amount of new bone formed in collagen matrix with daidzein was compared to that formed in collagen matrix alone. Eighteen bone defects, 5mm by 10mm were created in parietal bone of 9 New Zealand white rabbits. In the experimental group, 6 defects were grafted with collagen matrix with daidzein. In the control groups, 6 defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Serial sections were cut across each defect. Quantitative analysis of new bone formation was made on 100 sections (50 sections for each group of daidzein and positive control) using image analysis. A total of 602% more new bone was present in defects grafted with daidzein in collagen matrix than those grafted with the collagen matrix alone. Very little new bone formed in the negative control group. In conclusion, daidzein in collagen matrix has the effect of increasing new bone formation locally and can be used for bone grafting.
Persistent Identifierhttp://hdl.handle.net/10722/58000
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583
References

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-05-31T03:22:08Z-
dc.date.available2010-05-31T03:22:08Z-
dc.date.issued2009en_HK
dc.identifier.citationFrontiers In Bioscience, 2009, v. 14 n. 10, p. 3673-3679en_HK
dc.identifier.issn1093-9946en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58000-
dc.description.abstractThe amount of new bone formed in collagen matrix with daidzein was compared to that formed in collagen matrix alone. Eighteen bone defects, 5mm by 10mm were created in parietal bone of 9 New Zealand white rabbits. In the experimental group, 6 defects were grafted with collagen matrix with daidzein. In the control groups, 6 defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Serial sections were cut across each defect. Quantitative analysis of new bone formation was made on 100 sections (50 sections for each group of daidzein and positive control) using image analysis. A total of 602% more new bone was present in defects grafted with daidzein in collagen matrix than those grafted with the collagen matrix alone. Very little new bone formed in the negative control group. In conclusion, daidzein in collagen matrix has the effect of increasing new bone formation locally and can be used for bone grafting.en_HK
dc.languageengen_HK
dc.publisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/en_HK
dc.relation.ispartofFrontiers in Bioscienceen_HK
dc.subjectBone graften_HK
dc.subjectBone repairen_HK
dc.subjectDaidzeinen_HK
dc.titleEffect of daidzein on bone formationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1093-9946&volume=14&spage=3673&epage=3679&date=2009&atitle=Effect+of+Daidzein+on+Bone+Formationen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2735/3479en_HK
dc.identifier.pmid19273301-
dc.identifier.scopuseid_2-s2.0-63849147284en_HK
dc.identifier.hkuros154879en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-63849147284&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue10en_HK
dc.identifier.spage3673en_HK
dc.identifier.epage3679en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, RWK=36642905800en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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