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Article: The role of salivary factors in persistent oral carriage of Candida in humans

TitleThe role of salivary factors in persistent oral carriage of Candida in humans
Authors
Issue Date2009
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbio
Citation
Archives Of Oral Biology, 2009, v. 54 n. 7, p. 678-683 How to Cite?
AbstractBackground: Candida albicans is a commensal oral yeast in approximately one-third to one-half of the healthy population. To date, there are no studies investigating the multiple anti-candidal salivary constituents of healthy individuals with either nil or, consistent oral yeast carriage. Objective: To compare the composition and anti-candidal activity in stimulated whole saliva of healthy 'consistent' oral Candida carriers with Candida-free individuals. Methods: A sub-sample of 22 consistent, Candida-free individuals and 10 consistent Candida carriers were recruited from a 12 months screening study investigating oral Candida carriage in 97 healthy patients treated by fixed orthodontic appliances. Unstimulated and stimulated saliva samples were collected. The following salivary attributes were measured using standard methodology: the flow rate, pH, lysozyme, lactoferrin and IgA concentration and, the degree of inhibition of blastoconidial growth and blastospore germination. Results: Saliva from the Candida-free individuals showed 20.2% higher inhibition of blastoconidial growth (p < 0.05) of a reference strain of Candida albicans. No significant differences between the other salivary attributes of the two groups were found. Conclusion: The fact that saliva of Candida-free individuals significantly inhibited the blastoconidial growth more than Candida-carriers (p < 0.05) suggests that saliva may play a role in modulating oral candidal populations in health. Further studies, with a larger cohort are needed to confirm these findings and determine the factors that confer enhanced salivary anti-candidal activity. © 2009 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/57981
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.713
ISI Accession Number ID
Funding AgencyGrant Number
The University of Hong Kong7624/06M
10207346.15633
08003.323.01
Funding Information:

Funding: Grants-This study was supported by the University Research Grant no.7624/06M and 10207346.15633. 08003.323.01, The University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorHibino, Ken_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.contributor.authorHägg, Uen_HK
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorLee, Wen_HK
dc.date.accessioned2010-05-31T03:21:49Z-
dc.date.available2010-05-31T03:21:49Z-
dc.date.issued2009en_HK
dc.identifier.citationArchives Of Oral Biology, 2009, v. 54 n. 7, p. 678-683en_HK
dc.identifier.issn0003-9969en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57981-
dc.description.abstractBackground: Candida albicans is a commensal oral yeast in approximately one-third to one-half of the healthy population. To date, there are no studies investigating the multiple anti-candidal salivary constituents of healthy individuals with either nil or, consistent oral yeast carriage. Objective: To compare the composition and anti-candidal activity in stimulated whole saliva of healthy 'consistent' oral Candida carriers with Candida-free individuals. Methods: A sub-sample of 22 consistent, Candida-free individuals and 10 consistent Candida carriers were recruited from a 12 months screening study investigating oral Candida carriage in 97 healthy patients treated by fixed orthodontic appliances. Unstimulated and stimulated saliva samples were collected. The following salivary attributes were measured using standard methodology: the flow rate, pH, lysozyme, lactoferrin and IgA concentration and, the degree of inhibition of blastoconidial growth and blastospore germination. Results: Saliva from the Candida-free individuals showed 20.2% higher inhibition of blastoconidial growth (p < 0.05) of a reference strain of Candida albicans. No significant differences between the other salivary attributes of the two groups were found. Conclusion: The fact that saliva of Candida-free individuals significantly inhibited the blastoconidial growth more than Candida-carriers (p < 0.05) suggests that saliva may play a role in modulating oral candidal populations in health. Further studies, with a larger cohort are needed to confirm these findings and determine the factors that confer enhanced salivary anti-candidal activity. © 2009 Elsevier Ltd.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbioen_HK
dc.relation.ispartofArchives of Oral Biologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAntifungal Agents - analysis - pharmacologyen_HK
dc.subject.meshCandida - drug effects - growth & development - isolation & purificationen_HK
dc.subject.meshCandida albicans - drug effectsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHydrogen-Ion Concentrationen_HK
dc.subject.meshImmunoglobulin A, Secretory - analysisen_HK
dc.subject.meshLactoferrin - analysisen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMuramidase - analysisen_HK
dc.subject.meshSaliva - chemistry - microbiology - physiologyen_HK
dc.subject.meshSecretory Rate - physiologyen_HK
dc.subject.meshSpores, Fungal - drug effects - growth & developmenten_HK
dc.subject.meshYoung Adulten_HK
dc.titleThe role of salivary factors in persistent oral carriage of Candida in humansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9969&volume=54&spage=678&epage=683&date=2009&atitle=The+role+of+salivary+factors+in+persistent+oral+carriage+of+Candida+in+humansen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.emailHägg, U:euohagg@hkusua.hku.hken_HK
dc.identifier.emailWong, RWK:fyoung@hkucc.hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.archoralbio.2009.04.003en_HK
dc.identifier.pmid19439266-
dc.identifier.scopuseid_2-s2.0-67349227158en_HK
dc.identifier.hkuros155951en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349227158&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue7en_HK
dc.identifier.spage678en_HK
dc.identifier.epage683en_HK
dc.identifier.isiWOS:000267480800010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHibino, K=26632113100en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridLee, W=35191948000en_HK
dc.identifier.citeulike5347242-

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