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Article: Genetic overlap between bipolar illness and event-related potentials

TitleGenetic overlap between bipolar illness and event-related potentials
Authors
Issue Date2007
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2007, v. 37 n. 5, p. 667-678 How to Cite?
AbstractBackground. Electrophysiological endophenotypes are far less explored in bipolar disorder as compared to schizophrenia. No previous twin study of event-related potentials (ERPs) in bipolar illness has been reported. This study uses a twin design and advanced genetic model fitting analyses aiming to (1) assess and quantify the relationship of a range of ERP components with bipolar disorder with psychotic features, and (2) examine the source of the relationship (due to genetic or environmental factors). Method. P300, P50 suppression and mismatch negativity (MMN) were recorded in 10 discordant monozygotic (MZ) bipolar twin pairs, six concordant MZ bipolar twin pairs and 78 control twin pairs. Statistical analyses were based on structural equation modelling. Results. Bipolar disorder was significantly associated with smaller P300 amplitude and decreased P50 suppression. Genetic correlations were the main source of the associations, estimated to be -0.33 for P300 amplitude and 0·46 for P50 ratio. Individual-specific environmental influences were not significant. MMN and P300 latency were not associated with the illness. Conclusions. The results provide supporting evidence that P300 amplitude and P50 suppression ratio are ERP endophenotypes for bipolar disorder. © 2007 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/57543
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHall, MHen_HK
dc.contributor.authorRijsdijk, Fen_HK
dc.contributor.authorKalidindi, Sen_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorKravariti, Een_HK
dc.contributor.authorKane, Fen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2010-04-12T01:39:34Z-
dc.date.available2010-04-12T01:39:34Z-
dc.date.issued2007en_HK
dc.identifier.citationPsychological Medicine, 2007, v. 37 n. 5, p. 667-678en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57543-
dc.description.abstractBackground. Electrophysiological endophenotypes are far less explored in bipolar disorder as compared to schizophrenia. No previous twin study of event-related potentials (ERPs) in bipolar illness has been reported. This study uses a twin design and advanced genetic model fitting analyses aiming to (1) assess and quantify the relationship of a range of ERP components with bipolar disorder with psychotic features, and (2) examine the source of the relationship (due to genetic or environmental factors). Method. P300, P50 suppression and mismatch negativity (MMN) were recorded in 10 discordant monozygotic (MZ) bipolar twin pairs, six concordant MZ bipolar twin pairs and 78 control twin pairs. Statistical analyses were based on structural equation modelling. Results. Bipolar disorder was significantly associated with smaller P300 amplitude and decreased P50 suppression. Genetic correlations were the main source of the associations, estimated to be -0.33 for P300 amplitude and 0·46 for P50 ratio. Individual-specific environmental influences were not significant. MMN and P300 latency were not associated with the illness. Conclusions. The results provide supporting evidence that P300 amplitude and P50 suppression ratio are ERP endophenotypes for bipolar disorder. © 2007 Cambridge University Press.en_HK
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.en_HK
dc.subject.meshBipolar Disorder - genetics - physiopathologyen_HK
dc.subject.meshEvoked Potentials - physiologyen_HK
dc.subject.meshGenes, Overlapping - geneticsen_HK
dc.subject.meshTwins - geneticsen_HK
dc.subject.meshEvent-Related Potentials, P300 - physiologyen_HK
dc.titleGenetic overlap between bipolar illness and event-related potentialsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0033-2917&volume=37&issue=5&spage=667&epage=678&date=2007&atitle=Genetic+overlap+between+bipolar+illness+and+event-related+potentialsen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1017/S003329170600972Xen_HK
dc.identifier.pmid17224092-
dc.identifier.scopuseid_2-s2.0-34047123831en_HK
dc.identifier.hkuros133086-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34047123831&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue5en_HK
dc.identifier.spage667en_HK
dc.identifier.epage678en_HK
dc.identifier.isiWOS:000246193200007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHall, MH=14013171900en_HK
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_HK
dc.identifier.scopusauthoridKalidindi, S=24366595400en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridKravariti, E=8855469000en_HK
dc.identifier.scopusauthoridKane, F=24829114900en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

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