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Article: Early striatal hypertrophy in first-episode psychosis within 3 weeks of initiating antipsychotic drug treatment

TitleEarly striatal hypertrophy in first-episode psychosis within 3 weeks of initiating antipsychotic drug treatment
Authors
KeywordsAntipsychotic
Brain
First episode
MRI
Schizophrenia
Issue Date2009
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2009, v. 39 n. 5, p. 793-800 How to Cite?
AbstractBackground. We and others have reported that patients experiencing their first episode of psychosis already have significant structural brain abnormalities. Antipsychotics seem to reverse subcortical volume deficits after months of treatment. However, the early impact of medication on brain morphology is not known. Method. Forty-eight individuals in their first episode of psychosis underwent magnetic resonance imaging (MRI) brain scanning. Twenty-six were antipsychotic naive and 22 were newly treated with antipsychotic medication for a median period of 3 weeks. In each group, 80% of subjects received a diagnosis of schizophrenia. The two groups were balanced for age, sex, handedness, ethnicity, height, years of education, paternal socio-economic status (SES) and Positive and Negative Syndrome Scale (PANSS) score. Group differences in whole-brain grey matter were compared voxel by voxel, using Brain Activation and Morphological Mapping (BAMM) software. We also conducted testing of group differences with region-of-interest (ROI) measurements of the caudate nucleus. Results. Relative to the untreated group, those receiving antipsychotic medication for 3-4 weeks had significantly greater grey-matter volumes in the bilateral caudate and cingulate gyri, extending to the left medial frontal gyrus. ROI analysis confirmed that, in treated patients, the right and left caudate nuclei were significantly larger by 10% (p<0.039, two-tailed) and 9% (p<0.048, two-tailed) respectively. Conclusions. Early striatal grey-matter enlargement may occur within the first 3-4 weeks of antipsychotic treatment. Possible reasons for putative striatal hypertrophy and its implications are discussed. © Cambridge University Press 2008.
Persistent Identifierhttp://hdl.handle.net/10722/57542
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong Committee for Conference and Research Grants (CRCG)
Funding Information:

Dr S. E. Chua was supported by the University of Hong Kong Committee for Conference and Research Grants (CRCG). We thank the patients for their participation and staff of the Radiology Department, Queen Mary Hospital for MRI scanning.

References

 

DC FieldValueLanguage
dc.contributor.authorChua, SEen_HK
dc.contributor.authorDeng, Yen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorLaw, CWen_HK
dc.contributor.authorChiu, CPYen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorWong, JCHen_HK
dc.contributor.authorLienenkaëmper, Nen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorSuckling, Jen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.date.accessioned2010-04-12T01:39:33Z-
dc.date.available2010-04-12T01:39:33Z-
dc.date.issued2009en_HK
dc.identifier.citationPsychological Medicine, 2009, v. 39 n. 5, p. 793-800en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57542-
dc.description.abstractBackground. We and others have reported that patients experiencing their first episode of psychosis already have significant structural brain abnormalities. Antipsychotics seem to reverse subcortical volume deficits after months of treatment. However, the early impact of medication on brain morphology is not known. Method. Forty-eight individuals in their first episode of psychosis underwent magnetic resonance imaging (MRI) brain scanning. Twenty-six were antipsychotic naive and 22 were newly treated with antipsychotic medication for a median period of 3 weeks. In each group, 80% of subjects received a diagnosis of schizophrenia. The two groups were balanced for age, sex, handedness, ethnicity, height, years of education, paternal socio-economic status (SES) and Positive and Negative Syndrome Scale (PANSS) score. Group differences in whole-brain grey matter were compared voxel by voxel, using Brain Activation and Morphological Mapping (BAMM) software. We also conducted testing of group differences with region-of-interest (ROI) measurements of the caudate nucleus. Results. Relative to the untreated group, those receiving antipsychotic medication for 3-4 weeks had significantly greater grey-matter volumes in the bilateral caudate and cingulate gyri, extending to the left medial frontal gyrus. ROI analysis confirmed that, in treated patients, the right and left caudate nuclei were significantly larger by 10% (p<0.039, two-tailed) and 9% (p<0.048, two-tailed) respectively. Conclusions. Early striatal grey-matter enlargement may occur within the first 3-4 weeks of antipsychotic treatment. Possible reasons for putative striatal hypertrophy and its implications are discussed. © Cambridge University Press 2008.en_HK
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.en_HK
dc.subjectAntipsychoticen_HK
dc.subjectBrainen_HK
dc.subjectFirst episodeen_HK
dc.subjectMRIen_HK
dc.subjectSchizophreniaen_HK
dc.titleEarly striatal hypertrophy in first-episode psychosis within 3 weeks of initiating antipsychotic drug treatmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0033-2917&volume=39&issue=5&spage=793&epage=800&date=2008&atitle=Early+striatal+hypertrophy+in+first-episode+psychosis+within+3+weeks+of+initiating+antipsychotic+drug+treatmenten_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailChiu, CPY: chiupyc@hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authorityChiu, CPY=rp00291en_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1017/S0033291708004212en_HK
dc.identifier.pmid18713487en_HK
dc.identifier.scopuseid_2-s2.0-66849140908en_HK
dc.identifier.hkuros152338-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-66849140908&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue5en_HK
dc.identifier.spage793en_HK
dc.identifier.epage800en_HK
dc.identifier.isiWOS:000265569200011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.scopusauthoridDeng, Y=55459373300en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridLaw, CW=8627115600en_HK
dc.identifier.scopusauthoridChiu, CPY=8627115700en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK
dc.identifier.scopusauthoridWong, JCH=14036517700en_HK
dc.identifier.scopusauthoridLienenkaëmper, N=26432751700en_HK
dc.identifier.scopusauthoridCheung, V=7005439024en_HK
dc.identifier.scopusauthoridSuckling, J=7004124496en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK

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