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Article: High incidence of thrombophilia detected in Chinese patients with venous thrombosis
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TitleHigh incidence of thrombophilia detected in Chinese patients with venous thrombosis
 
AuthorsLiu, HW1
Kwong, YL1
Bourke, C1
Lam, CK1
Lie, AKW1
Wei, D1
Chan, LC1
 
Issue Date1994
 
PublisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com
 
CitationThrombosis And Haemostasis, 1994, v. 71 n. 4, p. 416-419 [How to Cite?]
 
AbstractVenous thromboembolism is rare in Chinese. To determine the incidence and disease profile of thrombophilia in Chinese patients with thrombosis, 52 unselected Chinese patients with documented venous thrombosis were studied for the presence of thrombophilia. Levels of antithrombin III (AT III), protein C (PC) and protein S (PS) as well as the presence of acquired lupus anticoagulant (LA) and anticardiolipin antibody (ACA) were investigated. Thirty patients were found to be abnormal. These consisted of 5 AT III deficiencies, 9 PC deficiencies, 10 PS deficiencies, 1 combined PC and PS deficiency (all in the heterozygous range), and 5 patients with LA and/or ACA. When the patients with LA and/or ACA are excluded, the incidence of hereditary thrombophilia is 25/47 i.e. 53.2% which is much higher than those reported in studies of Caucasian patients selected under strict criteria. Family studies performed in 16 cases of hereditary thrombophilia revealed involvement in 11 cases (68.7%); a total of 36 heterozygous family members were affected, most of which remain asymptomatic. Although 35 events predisposing to thrombosis (27 pregnancies, 1 oral contraceptive consumption and 7 surgical operations) were identified among these index patients, and the heterozygous family members, thrombosis was observed on only 6 occasions (17.1%). The data suggest that pregnancy and surgery do not carry the same degree of thrombotic risk in Chinese as in the Caucasian population with heterozygous AT III, PC and PS deficiency.
 
ISSN0340-6245
2012 Impact Factor: 6.094
2012 SCImago Journal Rankings: 2.077
 
ISI Accession Number IDWOS:A1994NE46500002
 
DC FieldValue
dc.contributor.authorLiu, HW
 
dc.contributor.authorKwong, YL
 
dc.contributor.authorBourke, C
 
dc.contributor.authorLam, CK
 
dc.contributor.authorLie, AKW
 
dc.contributor.authorWei, D
 
dc.contributor.authorChan, LC
 
dc.date.accessioned2010-04-12T01:39:00Z
 
dc.date.available2010-04-12T01:39:00Z
 
dc.date.issued1994
 
dc.description.abstractVenous thromboembolism is rare in Chinese. To determine the incidence and disease profile of thrombophilia in Chinese patients with thrombosis, 52 unselected Chinese patients with documented venous thrombosis were studied for the presence of thrombophilia. Levels of antithrombin III (AT III), protein C (PC) and protein S (PS) as well as the presence of acquired lupus anticoagulant (LA) and anticardiolipin antibody (ACA) were investigated. Thirty patients were found to be abnormal. These consisted of 5 AT III deficiencies, 9 PC deficiencies, 10 PS deficiencies, 1 combined PC and PS deficiency (all in the heterozygous range), and 5 patients with LA and/or ACA. When the patients with LA and/or ACA are excluded, the incidence of hereditary thrombophilia is 25/47 i.e. 53.2% which is much higher than those reported in studies of Caucasian patients selected under strict criteria. Family studies performed in 16 cases of hereditary thrombophilia revealed involvement in 11 cases (68.7%); a total of 36 heterozygous family members were affected, most of which remain asymptomatic. Although 35 events predisposing to thrombosis (27 pregnancies, 1 oral contraceptive consumption and 7 surgical operations) were identified among these index patients, and the heterozygous family members, thrombosis was observed on only 6 occasions (17.1%). The data suggest that pregnancy and surgery do not carry the same degree of thrombotic risk in Chinese as in the Caucasian population with heterozygous AT III, PC and PS deficiency.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationThrombosis And Haemostasis, 1994, v. 71 n. 4, p. 416-419 [How to Cite?]
 
dc.identifier.epage419
 
dc.identifier.hkuros5987
 
dc.identifier.isiWOS:A1994NE46500002
 
dc.identifier.issn0340-6245
2012 Impact Factor: 6.094
2012 SCImago Journal Rankings: 2.077
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmid8052955
 
dc.identifier.scopuseid_2-s2.0-0028293017
 
dc.identifier.spage416
 
dc.identifier.urihttp://hdl.handle.net/10722/57519
 
dc.identifier.volume71
 
dc.languageeng
 
dc.publisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com
 
dc.publisher.placeGermany
 
dc.relation.ispartofThrombosis and Haemostasis
 
dc.rightsThrombosis and Haemostasis. Copyright © Schattauer GmbH.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.rightsThis article is not an exact copy of the original published article in Thrombosis and Haemostasis. The definitive publisher-authenticated version of Thrombosis and Haemostasis, 1994, v. 71 n. 4, p. 416-419 is available online at: http://www.thrombosis-online.com
 
dc.subject.meshThromboembolism - epidemiology - ethnology - genetics
 
dc.subject.meshThrombophlebitis - etiology - genetics
 
dc.subject.meshAntithrombin III Deficiency
 
dc.subject.meshDisease Susceptibility - epidemiology
 
dc.subject.meshGenetic Predisposition to Disease
 
dc.titleHigh incidence of thrombophilia detected in Chinese patients with venous thrombosis
 
dc.typeArticle
 
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<contributor.author>Lie, AKW</contributor.author>
<contributor.author>Wei, D</contributor.author>
<contributor.author>Chan, LC</contributor.author>
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<description.abstract>Venous thromboembolism is rare in Chinese. To determine the incidence and disease profile of thrombophilia in Chinese patients with thrombosis, 52 unselected Chinese patients with documented venous thrombosis were studied for the presence of thrombophilia. Levels of antithrombin III (AT III), protein C (PC) and protein S (PS) as well as the presence of acquired lupus anticoagulant (LA) and anticardiolipin antibody (ACA) were investigated. Thirty patients were found to be abnormal. These consisted of 5 AT III deficiencies, 9 PC deficiencies, 10 PS deficiencies, 1 combined PC and PS deficiency (all in the heterozygous range), and 5 patients with LA and/or ACA. When the patients with LA and/or ACA are excluded, the incidence of hereditary thrombophilia is 25/47 i.e. 53.2% which is much higher than those reported in studies of Caucasian patients selected under strict criteria. Family studies performed in 16 cases of hereditary thrombophilia revealed involvement in 11 cases (68.7%); a total of 36 heterozygous family members were affected, most of which remain asymptomatic. Although 35 events predisposing to thrombosis (27 pregnancies, 1 oral contraceptive consumption and 7 surgical operations) were identified among these index patients, and the heterozygous family members, thrombosis was observed on only 6 occasions (17.1%). The data suggest that pregnancy and surgery do not carry the same degree of thrombotic risk in Chinese as in the Caucasian population with heterozygous AT III, PC and PS deficiency.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong