File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: High incidence of thrombophilia detected in Chinese patients with venous thrombosis

TitleHigh incidence of thrombophilia detected in Chinese patients with venous thrombosis
Authors
Issue Date1994
PublisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com
Citation
Thrombosis And Haemostasis, 1994, v. 71 n. 4, p. 416-419 How to Cite?
AbstractVenous thromboembolism is rare in Chinese. To determine the incidence and disease profile of thrombophilia in Chinese patients with thrombosis, 52 unselected Chinese patients with documented venous thrombosis were studied for the presence of thrombophilia. Levels of antithrombin III (AT III), protein C (PC) and protein S (PS) as well as the presence of acquired lupus anticoagulant (LA) and anticardiolipin antibody (ACA) were investigated. Thirty patients were found to be abnormal. These consisted of 5 AT III deficiencies, 9 PC deficiencies, 10 PS deficiencies, 1 combined PC and PS deficiency (all in the heterozygous range), and 5 patients with LA and/or ACA. When the patients with LA and/or ACA are excluded, the incidence of hereditary thrombophilia is 25/47 i.e. 53.2% which is much higher than those reported in studies of Caucasian patients selected under strict criteria. Family studies performed in 16 cases of hereditary thrombophilia revealed involvement in 11 cases (68.7%); a total of 36 heterozygous family members were affected, most of which remain asymptomatic. Although 35 events predisposing to thrombosis (27 pregnancies, 1 oral contraceptive consumption and 7 surgical operations) were identified among these index patients, and the heterozygous family members, thrombosis was observed on only 6 occasions (17.1%). The data suggest that pregnancy and surgery do not carry the same degree of thrombotic risk in Chinese as in the Caucasian population with heterozygous AT III, PC and PS deficiency.
Persistent Identifierhttp://hdl.handle.net/10722/57519
ISSN
2014 Impact Factor: 4.984
2014 SCImago Journal Rankings: 1.562
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, HWen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorBourke, Cen_HK
dc.contributor.authorLam, CKen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorWei, Den_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2010-04-12T01:39:00Z-
dc.date.available2010-04-12T01:39:00Z-
dc.date.issued1994en_HK
dc.identifier.citationThrombosis And Haemostasis, 1994, v. 71 n. 4, p. 416-419en_HK
dc.identifier.issn0340-6245en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57519-
dc.description.abstractVenous thromboembolism is rare in Chinese. To determine the incidence and disease profile of thrombophilia in Chinese patients with thrombosis, 52 unselected Chinese patients with documented venous thrombosis were studied for the presence of thrombophilia. Levels of antithrombin III (AT III), protein C (PC) and protein S (PS) as well as the presence of acquired lupus anticoagulant (LA) and anticardiolipin antibody (ACA) were investigated. Thirty patients were found to be abnormal. These consisted of 5 AT III deficiencies, 9 PC deficiencies, 10 PS deficiencies, 1 combined PC and PS deficiency (all in the heterozygous range), and 5 patients with LA and/or ACA. When the patients with LA and/or ACA are excluded, the incidence of hereditary thrombophilia is 25/47 i.e. 53.2% which is much higher than those reported in studies of Caucasian patients selected under strict criteria. Family studies performed in 16 cases of hereditary thrombophilia revealed involvement in 11 cases (68.7%); a total of 36 heterozygous family members were affected, most of which remain asymptomatic. Although 35 events predisposing to thrombosis (27 pregnancies, 1 oral contraceptive consumption and 7 surgical operations) were identified among these index patients, and the heterozygous family members, thrombosis was observed on only 6 occasions (17.1%). The data suggest that pregnancy and surgery do not carry the same degree of thrombotic risk in Chinese as in the Caucasian population with heterozygous AT III, PC and PS deficiency.en_HK
dc.languageengen_HK
dc.publisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.comen_HK
dc.relation.ispartofThrombosis and Haemostasisen_HK
dc.rightsThrombosis and Haemostasis. Copyright © Schattauer GmbH.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis article is not an exact copy of the original published article in Thrombosis and Haemostasis. The definitive publisher-authenticated version of Thrombosis and Haemostasis, 1994, v. 71 n. 4, p. 416-419 is available online at: http://www.thrombosis-online.comen_HK
dc.subject.meshThromboembolism - epidemiology - ethnology - geneticsen_HK
dc.subject.meshThrombophlebitis - etiology - geneticsen_HK
dc.subject.meshAntithrombin III Deficiencyen_HK
dc.subject.meshDisease Susceptibility - epidemiologyen_HK
dc.subject.meshGenetic Predisposition to Diseaseen_HK
dc.titleHigh incidence of thrombophilia detected in Chinese patients with venous thrombosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0340-6245&volume=71&issue=4&spage=416&epage=419&date=1994&atitle=High+incidence+of+thrombophilia+detected+in+Chinese+patients+with+venous+thrombosisen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8052955en_HK
dc.identifier.scopuseid_2-s2.0-0028293017en_HK
dc.identifier.hkuros5987-
dc.identifier.volume71en_HK
dc.identifier.issue4en_HK
dc.identifier.spage416en_HK
dc.identifier.epage419en_HK
dc.identifier.isiWOS:A1994NE46500002-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLiu, HW=7409752648en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridBourke, C=7004240621en_HK
dc.identifier.scopusauthoridLam, CK=7402990801en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridWei, D=7202909037en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats