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Article: Aberrant gene methylation implicated in the progression of monoclonal gammopathy of undetermined significance to multiple myeloma

TitleAberrant gene methylation implicated in the progression of monoclonal gammopathy of undetermined significance to multiple myeloma
Authors
Issue Date2007
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 2007, v. 60 n. 1, p. 104-106 How to Cite?
AbstractMalignant transformation is a multistep process that may involve dysregulation of oncogenes and tumour suppressor genes, and monoclonal gammopathy of undetermined significance (MGUS) is believed to be a precursor of multiple myeloma. To investigate whether aberrant promoter methylation might be involved in the evolution of MGUS to multiple myeloma, we examined the p16, protein tyrosine phosphatase, non-receptor type 6 (SHP1), death-associated protein (DAP) kinase, E-cadherin and oestrogen receptor genes, most being tumour suppressor genes, by methylation-specific polymerase chain reaction. In 32 cases of multiple myeloma and 19 cases of MGUS, significantly more frequent methylation of p16 (p = 0.001), SHP1 (p ≤ 0.001) and E-cadherin (p ≤ 0.001) genes was found in multiple myeloma than in MGUS. Methylation of DAP kinase and oestrogen receptor genes was comparable in multiple myeloma and MGUS. In conclusion, methylation of p16, SHP1 and E-cadherin genes might be involved in the progression of MGUS to multiple myeloma.
Persistent Identifierhttp://hdl.handle.net/10722/57518
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChim, CSen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorLeung, MHen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-04-12T01:38:59Z-
dc.date.available2010-04-12T01:38:59Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Clinical Pathology, 2007, v. 60 n. 1, p. 104-106en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57518-
dc.description.abstractMalignant transformation is a multistep process that may involve dysregulation of oncogenes and tumour suppressor genes, and monoclonal gammopathy of undetermined significance (MGUS) is believed to be a precursor of multiple myeloma. To investigate whether aberrant promoter methylation might be involved in the evolution of MGUS to multiple myeloma, we examined the p16, protein tyrosine phosphatase, non-receptor type 6 (SHP1), death-associated protein (DAP) kinase, E-cadherin and oestrogen receptor genes, most being tumour suppressor genes, by methylation-specific polymerase chain reaction. In 32 cases of multiple myeloma and 19 cases of MGUS, significantly more frequent methylation of p16 (p = 0.001), SHP1 (p ≤ 0.001) and E-cadherin (p ≤ 0.001) genes was found in multiple myeloma than in MGUS. Methylation of DAP kinase and oestrogen receptor genes was comparable in multiple myeloma and MGUS. In conclusion, methylation of p16, SHP1 and E-cadherin genes might be involved in the progression of MGUS to multiple myeloma.en_HK
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of clinical pathology. Copyright © B M J Publishing Group.en_HK
dc.subject.meshDNA Methylationen_HK
dc.subject.meshParaproteinemias - geneticsen_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshDNA, Neoplasm - geneticsen_HK
dc.subject.meshDisease Progressionen_HK
dc.titleAberrant gene methylation implicated in the progression of monoclonal gammopathy of undetermined significance to multiple myelomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=60&issue=1&spage=104&epage=106&date=2007&atitle=Aberrant+gene+methylation+implicated+in+the+progression+of+monoclonal+gammopathy+of+undetermined+significance+to+multiple+myelomaen_HK
dc.identifier.emailChim, CS:jcschim@hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityChim, CS=rp00408en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/jcp.2006.036715en_HK
dc.identifier.pmid17213358-
dc.identifier.pmcidPMC1860599-
dc.identifier.scopuseid_2-s2.0-33846425692en_HK
dc.identifier.hkuros136732-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846425692&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume60en_HK
dc.identifier.issue1en_HK
dc.identifier.spage104en_HK
dc.identifier.epage106en_HK
dc.identifier.isiWOS:000243684000020-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChim, CS=7004597253en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridLeung, MH=13807434600en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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