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Article: The effects of rhizoma curculiginis and rhizoma drynariae extracts on bones

TitleThe effects of rhizoma curculiginis and rhizoma drynariae extracts on bones
Authors
Issue Date2007
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/home
Citation
Chinese Medicine, 2007, v. 2, article no. 13 How to Cite?
AbstractBackground: Rhizoma Curculiginis (Xianmao) and Rhizoma Drynariae (Gusuibu) are 'Yang-tonifying' traditional Chinese herbal medicines used to strengthen bones. This investigation aims to assess the systemic effect of extracts of Rhizoma Curculiginis and Rhizoma Drynariae on bone histomorphology and formation, and their local effect on bone healing. Methods: For the investigation of the systemic effect, thirty 8-week-old male BALB/c mice were divided into three groups: (1) control group, ten mice fed daily with distilled water; (2) Rhizoma Curculiginis group, ten mice fed daily with distilled water mixed with Rhizoma Curculiginis extract; (3) Rhizoma Drynarie group, ten mice fed daily with distilled water mixed with Rhizoma Drynarie extract. The mice were fed for five weeks before sacrifice. Twenty micro-tomographic slices with an increment of 0.25 mm were prepared to cover the proximal end of the left tibia of each mouse. Quantitative morphometry of the bone structure was performed. For the investigation of the local effect on bone healing, two bone defects (5 × 10 mm) were created in the parietal bone of each of the three New Zealand white rabbits. Two defects in the first animal were grafted with collagen matrix with Rhizoma Curculiginis extract; two defects in the second animal were grafted with collagen matrix with Rhizoma Drynarie extract; two defects in the third (control) animal were grafted with collagen matrix alone. The animals were sacrificed on day 14 and the defects were dissected and prepared for histological and ultrastructural assessment. Results: Rhizoma Curculiginis and Rhizoma Drynariae extracts altered the bone histomorphology, both increasing the trabecular number by 10% (P = 0.002). Rhizoma Curculiginis extract increased bone density by 3.13% (P = 0.122) and Rhizoma Drynariae extract increased bone density by 6.45% (P = 0.005). Both Rhizoma Curculiginis and Rhizoma Drynariae extracts induced new bone formation on the margins of the defects. Conclusion: Two 'Yang-tonifying' herbs, Rhizoma Curculiginis and Rhizoma Drynariae, were demonstrated to have systemic effects on bone histomorphology and formation as well as local bone healing. © 2007 Wong et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/57424
ISSN
2015 Impact Factor: 1.58
2015 SCImago Journal Rankings: 0.655
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, Ben_HK
dc.contributor.authorBendeus, Men_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2010-04-12T01:36:14Z-
dc.date.available2010-04-12T01:36:14Z-
dc.date.issued2007en_HK
dc.identifier.citationChinese Medicine, 2007, v. 2, article no. 13en_HK
dc.identifier.issn1749-8546en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57424-
dc.description.abstractBackground: Rhizoma Curculiginis (Xianmao) and Rhizoma Drynariae (Gusuibu) are 'Yang-tonifying' traditional Chinese herbal medicines used to strengthen bones. This investigation aims to assess the systemic effect of extracts of Rhizoma Curculiginis and Rhizoma Drynariae on bone histomorphology and formation, and their local effect on bone healing. Methods: For the investigation of the systemic effect, thirty 8-week-old male BALB/c mice were divided into three groups: (1) control group, ten mice fed daily with distilled water; (2) Rhizoma Curculiginis group, ten mice fed daily with distilled water mixed with Rhizoma Curculiginis extract; (3) Rhizoma Drynarie group, ten mice fed daily with distilled water mixed with Rhizoma Drynarie extract. The mice were fed for five weeks before sacrifice. Twenty micro-tomographic slices with an increment of 0.25 mm were prepared to cover the proximal end of the left tibia of each mouse. Quantitative morphometry of the bone structure was performed. For the investigation of the local effect on bone healing, two bone defects (5 × 10 mm) were created in the parietal bone of each of the three New Zealand white rabbits. Two defects in the first animal were grafted with collagen matrix with Rhizoma Curculiginis extract; two defects in the second animal were grafted with collagen matrix with Rhizoma Drynarie extract; two defects in the third (control) animal were grafted with collagen matrix alone. The animals were sacrificed on day 14 and the defects were dissected and prepared for histological and ultrastructural assessment. Results: Rhizoma Curculiginis and Rhizoma Drynariae extracts altered the bone histomorphology, both increasing the trabecular number by 10% (P = 0.002). Rhizoma Curculiginis extract increased bone density by 3.13% (P = 0.122) and Rhizoma Drynariae extract increased bone density by 6.45% (P = 0.005). Both Rhizoma Curculiginis and Rhizoma Drynariae extracts induced new bone formation on the margins of the defects. Conclusion: Two 'Yang-tonifying' herbs, Rhizoma Curculiginis and Rhizoma Drynariae, were demonstrated to have systemic effects on bone histomorphology and formation as well as local bone healing. © 2007 Wong et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/homeen_HK
dc.relation.ispartofChinese Medicineen_HK
dc.rightsChinese Medicine. Copyright © BioMed Central Ltd.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshRhizoma Curculiginisen_HK
dc.subject.meshRhizoma Drynariaeen_HK
dc.subject.meshbonesen_HK
dc.subject.meshMedical Sciencesen_HK
dc.titleThe effects of rhizoma curculiginis and rhizoma drynariae extracts on bonesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1749-8546&volume=2 article no. 13&spage=&epage=&date=2007&atitle=The+effects+of+Rhizoma+Curculiginis+and+Rhizoma+Drynariae+extracts+on+bonesen_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailRabie, B: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, B=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1186/1749-8546-2-13en_HK
dc.identifier.pmid18093297en_HK
dc.identifier.pmcidPMC2206024en_HK
dc.identifier.scopuseid_2-s2.0-38349142827en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38349142827&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2, article no. 13en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridRabie, B=7007172734en_HK
dc.identifier.scopusauthoridBendeus, M=6506522941en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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