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Article: Chinese red yeast rice (Monascus purpureus-fermented rice) promotes bone formation

TitleChinese red yeast rice (Monascus purpureus-fermented rice) promotes bone formation
Authors
KeywordsChinese red yeast rice
Monascus
purpureus-fermented
bone formation
Issue Date2008
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/home
Citation
Chinese Medicine, 2008, v. 3 How to Cite?
AbstractBackground: Statin can induce the gene expression of bone morphogenetic protein-2. Red yeast rice (RYR, Hongqu), i.e. rice fermented with Monascus purpureus, contains a natural form of statin. This study demonstrates the effects of RYR extract on bone formation. Methods: Bone defects were created in the parietal bones of two New Zealand white rabbits. In the test animal, two defects were grafted with collagen matrix mixed with RYR extract. In the control animal, two defects were grafted with collagen matrix alone. UMR 106 cell line was used to test RYR extract in vitro. In the control group, cells were cultured for three durations (24 hours, 48 hours and 72 hours) without any intervention. In the RYR group, cells were cultured for the same durations with various concentrations of RYR extract (0.001 g/ml, 0.005 g/ml and 0.01 g/ml). Bicinchoninic acid (BCA) assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and alkaline phosphatase (ALP) assay were performed to measure total protein, mitochondrial activity and bone cell formation respectively. Results: The test animal showed more formation of new bone in the defects than the control animal. RYR significantly increased the optical density in the MTT assay and ALP activity in vitro. Conclusion: RYR extract stimulated new bone formation in bone defects in vivo and increased bone cell formation in vitro. © 2008 Wong and Rabie; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/57422
ISSN
2015 Impact Factor: 1.58
2015 SCImago Journal Rankings: 0.655
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, Ben_HK
dc.date.accessioned2010-04-12T01:36:10Z-
dc.date.available2010-04-12T01:36:10Z-
dc.date.issued2008en_HK
dc.identifier.citationChinese Medicine, 2008, v. 3en_HK
dc.identifier.issn1749-8546en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57422-
dc.description.abstractBackground: Statin can induce the gene expression of bone morphogenetic protein-2. Red yeast rice (RYR, Hongqu), i.e. rice fermented with Monascus purpureus, contains a natural form of statin. This study demonstrates the effects of RYR extract on bone formation. Methods: Bone defects were created in the parietal bones of two New Zealand white rabbits. In the test animal, two defects were grafted with collagen matrix mixed with RYR extract. In the control animal, two defects were grafted with collagen matrix alone. UMR 106 cell line was used to test RYR extract in vitro. In the control group, cells were cultured for three durations (24 hours, 48 hours and 72 hours) without any intervention. In the RYR group, cells were cultured for the same durations with various concentrations of RYR extract (0.001 g/ml, 0.005 g/ml and 0.01 g/ml). Bicinchoninic acid (BCA) assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and alkaline phosphatase (ALP) assay were performed to measure total protein, mitochondrial activity and bone cell formation respectively. Results: The test animal showed more formation of new bone in the defects than the control animal. RYR significantly increased the optical density in the MTT assay and ALP activity in vitro. Conclusion: RYR extract stimulated new bone formation in bone defects in vivo and increased bone cell formation in vitro. © 2008 Wong and Rabie; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/homeen_HK
dc.relation.ispartofChinese Medicineen_HK
dc.rightsChinese Medicine. Copyright © BioMed Central Ltd.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectChinese red yeast riceen_HK
dc.subjectMonascusen_HK
dc.subjectpurpureus-fermenteden_HK
dc.subjectbone formationen_HK
dc.titleChinese red yeast rice (Monascus purpureus-fermented rice) promotes bone formationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1749-8546&volume=3 article no. 4&spage=&epage=&date=2008&atitle=Chinese+red+yeast+rice+(Monascus+purpureus-fermented+rice)+promotes+bone+formationen_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailRabie, B: rabie@hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, B=rp00029en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1186/1749-8546-3-4en_HK
dc.identifier.pmid18373874en_HK
dc.identifier.pmcidPMC2294127en_HK
dc.identifier.scopuseid_2-s2.0-42349110540en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42349110540&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridRabie, B=7007172734en_HK

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