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Article: Management and outcome of antenatally diagnosed congenital cystic adenomatoid malformation of the lung
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TitleManagement and outcome of antenatally diagnosed congenital cystic adenomatoid malformation of the lung
 
AuthorsChow, PC1
Lee, SL1
Tang, MHY1
Chan, KL1
Lee, CP1
Lam, BCC1
Tsoi, NS1
 
KeywordsCystic adenomatoid malformation of lung, congenital
Prenatal diagnosis
Treatment outcome
 
Issue Date2007
 
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
 
CitationHong Kong Medical Journal, 2007, v. 13 n. 1, p. 31-39 [How to Cite?]
 
AbstractObjective: To review the management and outcome of babies with antenatally diagnosed congenital cystic adenomatoid malformation. Design: Retrospective cohort review. Setting: Tertiary neonatal care unit at Queen Mary Hospital and antenatal diagnostic centre at Tsan Yuk Hospital. Patients: Consecutive patients with antenatally suspected congenital cystic adenomatoid malformation in their concepti among antenatal patients attending Tsan Yuk Hospital from 1994 to 2002. Twenty-four of 33 cases were referred to Queen Mary Hospital for postnatal management and for whom comprehensive records were available for analysis in 23. Interventions: Postnatal interventions in their babies included investigational imaging for congenital cystic adenomatoid malformation and surgery. Main outcome measures: Antenatal and postnatal outcome, as well as pathology of the excised lesions. Results: Antenatal outcome: termination of pregnancy in two cases and spontaneous abortion in one; in-utero regression was documented in nine cases and in one hydropic change was apparent. Postnatal outcome: only eight of 20 babies born alive had symptoms in neonatal period. Two developed serious infective complications in infancy, one with documented in-utero regression. Pulmonary parenchymal abnormalities were detected on computed tomography of the thorax in six of seven cases with normal or non-specific chest radiograph findings. Among nine cases with in-utero regression, congenital cystic adenomatoid malformation was confirmed by operative histology in five and abnormal computed tomography findings in three. Fifteen babies underwent surgical excision, one of whom died because of severe pre-existing pulmonary hypoplasia and nine endured minor postoperative complications. A favourable outcome was documented at a mean follow-up of 22 months (range, 2 months-7 years). Conclusions: In-utero regression of congenital cystic adenomatoid malformation on antenatal ultrasound may not represent genuine resolution. Computed tomographic thorax should be considered in all newborns with antenatally diagnosed congenital cystic adenomatoid malformation, and if confirmed early operation before first hospital discharge is recommended.
 
ISSN1024-2708
2013 SCImago Journal Rankings: 0.293
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChow, PC
 
dc.contributor.authorLee, SL
 
dc.contributor.authorTang, MHY
 
dc.contributor.authorChan, KL
 
dc.contributor.authorLee, CP
 
dc.contributor.authorLam, BCC
 
dc.contributor.authorTsoi, NS
 
dc.date.accessioned2010-04-12T01:35:44Z
 
dc.date.available2010-04-12T01:35:44Z
 
dc.date.issued2007
 
dc.description.abstractObjective: To review the management and outcome of babies with antenatally diagnosed congenital cystic adenomatoid malformation. Design: Retrospective cohort review. Setting: Tertiary neonatal care unit at Queen Mary Hospital and antenatal diagnostic centre at Tsan Yuk Hospital. Patients: Consecutive patients with antenatally suspected congenital cystic adenomatoid malformation in their concepti among antenatal patients attending Tsan Yuk Hospital from 1994 to 2002. Twenty-four of 33 cases were referred to Queen Mary Hospital for postnatal management and for whom comprehensive records were available for analysis in 23. Interventions: Postnatal interventions in their babies included investigational imaging for congenital cystic adenomatoid malformation and surgery. Main outcome measures: Antenatal and postnatal outcome, as well as pathology of the excised lesions. Results: Antenatal outcome: termination of pregnancy in two cases and spontaneous abortion in one; in-utero regression was documented in nine cases and in one hydropic change was apparent. Postnatal outcome: only eight of 20 babies born alive had symptoms in neonatal period. Two developed serious infective complications in infancy, one with documented in-utero regression. Pulmonary parenchymal abnormalities were detected on computed tomography of the thorax in six of seven cases with normal or non-specific chest radiograph findings. Among nine cases with in-utero regression, congenital cystic adenomatoid malformation was confirmed by operative histology in five and abnormal computed tomography findings in three. Fifteen babies underwent surgical excision, one of whom died because of severe pre-existing pulmonary hypoplasia and nine endured minor postoperative complications. A favourable outcome was documented at a mean follow-up of 22 months (range, 2 months-7 years). Conclusions: In-utero regression of congenital cystic adenomatoid malformation on antenatal ultrasound may not represent genuine resolution. Computed tomographic thorax should be considered in all newborns with antenatally diagnosed congenital cystic adenomatoid malformation, and if confirmed early operation before first hospital discharge is recommended.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationHong Kong Medical Journal, 2007, v. 13 n. 1, p. 31-39 [How to Cite?]
 
dc.identifier.epage39
 
dc.identifier.issn1024-2708
2013 SCImago Journal Rankings: 0.293
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid17277390
 
dc.identifier.scopuseid_2-s2.0-33947603060
 
dc.identifier.spage31
 
dc.identifier.urihttp://hdl.handle.net/10722/57409
 
dc.identifier.volume13
 
dc.languageeng
 
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofHong Kong Medical Journal
 
dc.relation.referencesReferences in Scopus
 
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectCystic adenomatoid malformation of lung, congenital
 
dc.subjectPrenatal diagnosis
 
dc.subjectTreatment outcome
 
dc.titleManagement and outcome of antenatally diagnosed congenital cystic adenomatoid malformation of the lung
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong