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Article: Neural Basis of Dyslexia: A Comparison between Dyslexic and Nondyslexic Children Equated for Reading Ability

TitleNeural Basis of Dyslexia: A Comparison between Dyslexic and Nondyslexic Children Equated for Reading Ability
Authors
KeywordsAge-matched
Dyslexia
Fmri
Parietotemporal region
Phonological processing
Reading ability-matched
Issue Date2006
PublisherSociety for Neuroscience. The Journal's web site is located at http://www.jneurosci.org
Citation
Journal Of Neuroscience, 2006, v. 26 n. 42, p. 10700-10708 How to Cite?
AbstractAdults and children with developmental dyslexia exhibit reduced parietotemporal activation in functional neuroimaging studies of phonological processing. These studies used age-matched and/or intelligence quotient-matched control groups whose reading ability and scanner task performance were often superior to that of the dyslexic group. It is unknown, therefore, whether differences in activation reflect simply poorer performance in the scanner, the underlying level of reading ability, or more specific neural correlates of dyslexia. To resolve this uncertainty, we conducted a functional magnetic resonance imaging study, with a rhyme judgment task, in which we compared dyslexic children with two control groups: age-matched children and reading-matched children (younger normal readers equated for reading ability or scanner-performance to the dyslexic children). Dyslexic children exhibited reduced activation relative to both age-matched and reading-matched children in the left parietotemporal cortex and five other regions, including the right parietotemporal cortex. The dyslexic children also exhibited reduced activation bilaterally in the parietotemporal cortex when compared with children equated for task performance during scanning. Nine of the 10 dyslexic children exhibited reduced left parietotemporal activation compared with their individually selected age-matched or reading-matched control children. Additionally, normal reading fifth graders showed more activation in the same bilateral parietotemporal regions than normal-reading third graders. These findings indicate that the activation differences seen in the dyslexic children cannot be accounted for by either current reading level or scanner task performance, but instead represent a distinct developmental atypicality in the neural systems that support learning to read. Copyright © 2006 Society for Neuroscience.
Persistent Identifierhttp://hdl.handle.net/10722/57397
ISSN
2015 Impact Factor: 5.924
2015 SCImago Journal Rankings: 5.105
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHoeft, Fen_HK
dc.contributor.authorHernandez, Aen_HK
dc.contributor.authorMcMillon, Gen_HK
dc.contributor.authorTaylorHill, Hen_HK
dc.contributor.authorMartindale, JLen_HK
dc.contributor.authorMeyler, Aen_HK
dc.contributor.authorKeller, TAen_HK
dc.contributor.authorWai, TSen_HK
dc.contributor.authorDeutsch, GKen_HK
dc.contributor.authorJust, MAen_HK
dc.contributor.authorWhitfieldGabrieli, Sen_HK
dc.contributor.authorGabrieli, JDEen_HK
dc.date.accessioned2010-04-12T01:35:18Z-
dc.date.available2010-04-12T01:35:18Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Neuroscience, 2006, v. 26 n. 42, p. 10700-10708en_HK
dc.identifier.issn0270-6474en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57397-
dc.description.abstractAdults and children with developmental dyslexia exhibit reduced parietotemporal activation in functional neuroimaging studies of phonological processing. These studies used age-matched and/or intelligence quotient-matched control groups whose reading ability and scanner task performance were often superior to that of the dyslexic group. It is unknown, therefore, whether differences in activation reflect simply poorer performance in the scanner, the underlying level of reading ability, or more specific neural correlates of dyslexia. To resolve this uncertainty, we conducted a functional magnetic resonance imaging study, with a rhyme judgment task, in which we compared dyslexic children with two control groups: age-matched children and reading-matched children (younger normal readers equated for reading ability or scanner-performance to the dyslexic children). Dyslexic children exhibited reduced activation relative to both age-matched and reading-matched children in the left parietotemporal cortex and five other regions, including the right parietotemporal cortex. The dyslexic children also exhibited reduced activation bilaterally in the parietotemporal cortex when compared with children equated for task performance during scanning. Nine of the 10 dyslexic children exhibited reduced left parietotemporal activation compared with their individually selected age-matched or reading-matched control children. Additionally, normal reading fifth graders showed more activation in the same bilateral parietotemporal regions than normal-reading third graders. These findings indicate that the activation differences seen in the dyslexic children cannot be accounted for by either current reading level or scanner task performance, but instead represent a distinct developmental atypicality in the neural systems that support learning to read. Copyright © 2006 Society for Neuroscience.en_HK
dc.languageengen_HK
dc.publisherSociety for Neuroscience. The Journal's web site is located at http://www.jneurosci.orgen_HK
dc.relation.ispartofJournal of Neuroscienceen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Neuroscience. Copyright © Society for Neuroscience.en_HK
dc.subjectAge-matcheden_HK
dc.subjectDyslexiaen_HK
dc.subjectFmrien_HK
dc.subjectParietotemporal regionen_HK
dc.subjectPhonological processingen_HK
dc.subjectReading ability-matcheden_HK
dc.titleNeural Basis of Dyslexia: A Comparison between Dyslexic and Nondyslexic Children Equated for Reading Abilityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-6474&volume=26&issue=42&spage=10700&epage=10708&date=2006&atitle=Neural+basis+of+dyslexia:+a+comparison+between+dyslexic+and+nondyslexic+children+equated+for+reading+abilityen_HK
dc.identifier.emailWai, TS: siok@hkucc.hku.hken_HK
dc.identifier.authorityWai, TS=rp01208en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1523/JNEUROSCI.4931-05.2006en_HK
dc.identifier.pmid17050709en_HK
dc.identifier.scopuseid_2-s2.0-33750959644en_HK
dc.identifier.hkuros128535-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750959644&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue42en_HK
dc.identifier.spage10700en_HK
dc.identifier.epage10708en_HK
dc.identifier.isiWOS:000241727300013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10001046849-
dc.identifier.scopusauthoridHoeft, F=15061514800en_HK
dc.identifier.scopusauthoridHernandez, A=15061550000en_HK
dc.identifier.scopusauthoridMcMillon, G=15061396800en_HK
dc.identifier.scopusauthoridTaylorHill, H=15062186700en_HK
dc.identifier.scopusauthoridMartindale, JL=36779565900en_HK
dc.identifier.scopusauthoridMeyler, A=8588987100en_HK
dc.identifier.scopusauthoridKeller, TA=34570122400en_HK
dc.identifier.scopusauthoridWai, TS=6602471035en_HK
dc.identifier.scopusauthoridDeutsch, GK=7006704228en_HK
dc.identifier.scopusauthoridJust, MA=7101650446en_HK
dc.identifier.scopusauthoridWhitfieldGabrieli, S=8910908400en_HK
dc.identifier.scopusauthoridGabrieli, JDE=7004907306en_HK

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