File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia

TitleA diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia
Authors
KeywordsDiffusion
First episode
Never medicated
Schizophrenia
Structural
Issue Date2008
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2008, v. 38 n. 6, p. 877-885 How to Cite?
AbstractBackground. Diffusion tensor imaging (DTI) can be used to investigate cerebral structural connectivity in never-medicated individuals with first-episode schizophrenia. Method. Subjects with first-episode schizophrenia according to DSM-IV-R who had never been exposed to antipsychotic medication (n=25) and healthy controls (n=26) were recruited. Groups were matched for age, gender, best parental socio-economic status and ethnicity. All subjects underwent DTI and structural magnetic resonance imaging (MRI) scans. Voxel-based analysis was performed to investigate brain regions where fractional anisotropy (FA) values differed significantly between groups. A confirmatory region-of-interest (ROI) analysis of FA scores was performed in which regions were placed blind to group membership. Results. In patients, FA values significantly lower than those in healthy controls were located in the left fronto-occipital fasciculus, left inferior longitudinal fasciculus, white matter adjacent to right precuneus, splenium of corpus callosum, right posterior limb of internal capsule, white matter adjacent to right substantia nigra, and left cerebral peduncle. ROI analysis of the corpus callosum confirmed that the patient group had significantly lower mean FA values than the controls in the splenium but not in the genu. The intra-class correlation coefficient (ICC) for independent ROI measurements was 0.90 (genu) and 0.90 (splenium). There were no regions where FA values were significantly higher in the patients than in the healthy controls. Conclusions. Widespread structural dysconnectivity, including the subcortical region, is already present in neuroleptic-naive patients in their first episode of illness. © 2007 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/57394
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorDeng, Yen_HK
dc.contributor.authorWong, JGen_HK
dc.contributor.authorYip, Len_HK
dc.contributor.authorTai, KSen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorChua, SEen_HK
dc.date.accessioned2010-04-12T01:35:10Z-
dc.date.available2010-04-12T01:35:10Z-
dc.date.issued2008en_HK
dc.identifier.citationPsychological Medicine, 2008, v. 38 n. 6, p. 877-885en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57394-
dc.description.abstractBackground. Diffusion tensor imaging (DTI) can be used to investigate cerebral structural connectivity in never-medicated individuals with first-episode schizophrenia. Method. Subjects with first-episode schizophrenia according to DSM-IV-R who had never been exposed to antipsychotic medication (n=25) and healthy controls (n=26) were recruited. Groups were matched for age, gender, best parental socio-economic status and ethnicity. All subjects underwent DTI and structural magnetic resonance imaging (MRI) scans. Voxel-based analysis was performed to investigate brain regions where fractional anisotropy (FA) values differed significantly between groups. A confirmatory region-of-interest (ROI) analysis of FA scores was performed in which regions were placed blind to group membership. Results. In patients, FA values significantly lower than those in healthy controls were located in the left fronto-occipital fasciculus, left inferior longitudinal fasciculus, white matter adjacent to right precuneus, splenium of corpus callosum, right posterior limb of internal capsule, white matter adjacent to right substantia nigra, and left cerebral peduncle. ROI analysis of the corpus callosum confirmed that the patient group had significantly lower mean FA values than the controls in the splenium but not in the genu. The intra-class correlation coefficient (ICC) for independent ROI measurements was 0.90 (genu) and 0.90 (splenium). There were no regions where FA values were significantly higher in the patients than in the healthy controls. Conclusions. Widespread structural dysconnectivity, including the subcortical region, is already present in neuroleptic-naive patients in their first episode of illness. © 2007 Cambridge University Press.en_HK
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectDiffusionen_HK
dc.subjectFirst episodeen_HK
dc.subjectNever medicateden_HK
dc.subjectSchizophreniaen_HK
dc.subjectStructuralen_HK
dc.subject.meshBrain - pathology - physiopathologyen_HK
dc.subject.meshDiffusion Magnetic Resonance Imagingen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshNerve Net - pathology - physiopathologyen_HK
dc.titleA diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0033-2917&volume=38&issue=6&spage=877&epage=885&date=2008&atitle=A+diffusion+tensor+imaging+study+of+structural+dysconnectivity+in+never-medicated,+first-episode+schizophreniaen_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1017/S0033291707001808en_HK
dc.identifier.pmid17949516-
dc.identifier.scopuseid_2-s2.0-43649102071en_HK
dc.identifier.hkuros142761-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-43649102071&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue6en_HK
dc.identifier.spage877en_HK
dc.identifier.epage885en_HK
dc.identifier.eissn1469-8978-
dc.identifier.isiWOS:000256844800013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, V=7005439024en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridDeng, Y=55459373300en_HK
dc.identifier.scopusauthoridWong, JG=7404435750en_HK
dc.identifier.scopusauthoridYip, L=7006233502en_HK
dc.identifier.scopusauthoridTai, KS=7101738949en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats