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Article: Perioperative use of statins in noncardiac surgery

TitlePerioperative use of statins in noncardiac surgery
Authors
KeywordsCardiac complications
Morbidity
Mortality
Noncardiac surgery
Outcome
Perioperative
Statins
Vascular
Issue Date2008
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=2
Citation
Vascular Health And Risk Management, 2008, v. 4 n. 1, p. 75-81 How to Cite?
AbstractBackground: Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) can significantly decrease cardiovascular mortality and morbidity, irrespective of the patients' cholesterol status. This paper reviews the effects of perioperative statin therapy in patients undergoing noncardiac surgery. Method: A systematic literature review was undertaken of all published literature on this subject using Medline and cross-referenced. All published relevant papers on the perioperative use of statins were used. Results: Perioperative statin therapy is associated with a lower perioperative morbidity and mortality in patients undergoing elective or emergency surgery. The effects are due to a combination of lipid-lowering and pleiotropic properties of statins. Conclusion: Ideally a large scale multi-centre randomized controlled trial of perioperative statin therapy should be performed but this may be difficult to conduct since there is already overwhelming evidence in the literature to suggest perioperative cardiovascular protective properties. Statins may still be under-prescribed in surgical patients. © 2008 Chan et al, publisher and licensee Dove Medical Press Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/57358
ISSN
2015 SCImago Journal Rankings: 0.965
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, YCen_HK
dc.contributor.authorCheng, SWen_HK
dc.contributor.authorIrwin, MGen_HK
dc.date.accessioned2010-04-12T01:34:09Z-
dc.date.available2010-04-12T01:34:09Z-
dc.date.issued2008en_HK
dc.identifier.citationVascular Health And Risk Management, 2008, v. 4 n. 1, p. 75-81en_HK
dc.identifier.issn1176-6344en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57358-
dc.description.abstractBackground: Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) can significantly decrease cardiovascular mortality and morbidity, irrespective of the patients' cholesterol status. This paper reviews the effects of perioperative statin therapy in patients undergoing noncardiac surgery. Method: A systematic literature review was undertaken of all published literature on this subject using Medline and cross-referenced. All published relevant papers on the perioperative use of statins were used. Results: Perioperative statin therapy is associated with a lower perioperative morbidity and mortality in patients undergoing elective or emergency surgery. The effects are due to a combination of lipid-lowering and pleiotropic properties of statins. Conclusion: Ideally a large scale multi-centre randomized controlled trial of perioperative statin therapy should be performed but this may be difficult to conduct since there is already overwhelming evidence in the literature to suggest perioperative cardiovascular protective properties. Statins may still be under-prescribed in surgical patients. © 2008 Chan et al, publisher and licensee Dove Medical Press Ltd.en_HK
dc.languageengen_HK
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=2en_HK
dc.relation.ispartofVascular Health and Risk Managementen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCardiac complicationsen_HK
dc.subjectMorbidityen_HK
dc.subjectMortalityen_HK
dc.subjectNoncardiac surgeryen_HK
dc.subjectOutcomeen_HK
dc.subjectPerioperativeen_HK
dc.subjectStatinsen_HK
dc.subjectVascularen_HK
dc.subject.meshHydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic useen_HK
dc.subject.meshPerioperative Careen_HK
dc.subject.meshPostoperative Complications - prevention & controlen_HK
dc.subject.meshSurgical Procedures, Operativeen_HK
dc.subject.meshVascular Diseases - surgeryen_HK
dc.titlePerioperative use of statins in noncardiac surgeryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1176-6344&volume=4&issue=1&spage=75&epage=81&date=2008&atitle=Perioperative+use+of+statins+in+noncardiac+surgeryen_HK
dc.identifier.emailChan, YC: ycchan88@hkucc.hku.hken_HK
dc.identifier.emailCheng, SW: wkcheng@hkucc.hku.hken_HK
dc.identifier.emailIrwin, MG: mgirwin@hku.hken_HK
dc.identifier.authorityChan, YC=rp00530en_HK
dc.identifier.authorityCheng, SW=rp00374en_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.2147/vhrm.2008.04.01.75en_HK
dc.identifier.pmid18629359-
dc.identifier.pmcidPMC2464754en_HK
dc.identifier.scopuseid_2-s2.0-41549166122en_HK
dc.identifier.hkuros145396-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41549166122&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue1en_HK
dc.identifier.spage75en_HK
dc.identifier.epage81en_HK
dc.publisher.placeNew Zealanden_HK
dc.identifier.scopusauthoridChan, YC=27170769400en_HK
dc.identifier.scopusauthoridCheng, SW=7404684779en_HK
dc.identifier.scopusauthoridIrwin, MG=7202411076en_HK

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