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Article: Preparation and biomedical application of a non-polymer coated superparamagnetic nanoparticle

TitlePreparation and biomedical application of a non-polymer coated superparamagnetic nanoparticle
Authors
Issue Date2007
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=5
Citation
International Journal of Nanomedicine, 2007, v. 2 n. 4, p. 805-812 How to Cite?
AbstractWe report the preparation of a non-polymer coated superparamagnetic nanoparticle that is stable and biocompatible both in vitro and in vivo. The non-polymer, betaine, is a natural methylating agent in mammalian liver with active surface property. Upon systemic administration, the nanoparticle has preferential biodistribution in mammalian liver and exhibits good reduction of relaxivity time and negative enhancement for the detection of hepatoma nodules in rats using MRI. Our data demonstrate that the non-polymer coated superparamagnetic nanoparticle should have potential applications in biomedicine.
Persistent Identifierhttp://hdl.handle.net/10722/57309
ISSN
2010 Impact Factor: 4.976
2015 SCImago Journal Rankings: 1.351
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDu, Len_HK
dc.contributor.authorChen, Jen_HK
dc.contributor.authorQi, Yen_HK
dc.contributor.authorLi, Den_HK
dc.contributor.authorYuan, Cen_HK
dc.contributor.authorLin, MCen_HK
dc.contributor.authorYew, DTen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorYu, JCen_HK
dc.contributor.authorLai, Len_HK
dc.date.accessioned2010-04-12T01:32:46Z-
dc.date.available2010-04-12T01:32:46Z-
dc.date.issued2007en_HK
dc.identifier.citationInternational Journal of Nanomedicine, 2007, v. 2 n. 4, p. 805-812en_HK
dc.identifier.issn1176-9114en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57309-
dc.description.abstractWe report the preparation of a non-polymer coated superparamagnetic nanoparticle that is stable and biocompatible both in vitro and in vivo. The non-polymer, betaine, is a natural methylating agent in mammalian liver with active surface property. Upon systemic administration, the nanoparticle has preferential biodistribution in mammalian liver and exhibits good reduction of relaxivity time and negative enhancement for the detection of hepatoma nodules in rats using MRI. Our data demonstrate that the non-polymer coated superparamagnetic nanoparticle should have potential applications in biomedicine.en_HK
dc.languageengen_HK
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=5en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarcinoma, Hepatocellular - diagnosisen_HK
dc.subject.meshContrast Media - chemistryen_HK
dc.subject.meshIron - chemistry - diagnostic useen_HK
dc.subject.meshLiver Neoplasms - diagnosisen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.titlePreparation and biomedical application of a non-polymer coated superparamagnetic nanoparticleen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1176-9114&volume=2&issue=4&spage=805&epage=812&date=2007&atitle=Preparation+and+biomedical+application+of+a+non-polymer+coated+superparamagnetic+nanoparticleen_HK
dc.identifier.emailLin, MC: mcllin@hkucc.hku.hken_HK
dc.identifier.emailLai, L: lhlai@bio.ecnu.edu.cnen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid18203447en_HK
dc.identifier.pmcidPMC2676809en_HK
dc.identifier.hkuros140007-
dc.identifier.isiWOS:000252357400028-

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