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Article: Phenotypic and population differences in the association between CILP and lumbar disc disease

TitlePhenotypic and population differences in the association between CILP and lumbar disc disease
Authors
Issue Date2007
PublisherBMJ Group. The Journal's web site is located at http://jmg.bmj.com/
Citation
Journal Of Medical Genetics, 2007, v. 44 n. 4, p. 285-288 How to Cite?
AbstractBackground: Lumbar disc disease (LDD) is one of the leading causes of disability in the working-age population. A functional single-nucleotide polymorphism (SNP), +1184T→C, in exon 8 of the cartilage intermediate layer protein gene (CILP) was recently identified as a risk factor for LDD in the Japanese population (odds ratio (OR) 1.61, 95% CI 1.31 to 1.98), with implications for impaired transforming growth factorβ1 signalling. Aim: To validate this finding in two different ethnic cohorts with LDD. Methods: This SNP and flanking SNPs were analysed in 243 Finnish patients with symptoms of LDD and 259 controls, and in 348 Chinese subjects with MRI-defined LDD and 343 controls. Results and conclusion: The results showed no evidence of association in the Finnish (OR = 1.35, 95% CI 0.97 to 1.87; p = 0.14) or the Chinese (OR = 1.05, 95% CI 0.77 to 1.43; p = 0.71) samples, suggesting that cartilage intermediate layer protein gene is not a major risk factor for symptoms of LDD in Caucasians or in the general population that included individuals with or without symptoms.
Persistent Identifierhttp://hdl.handle.net/10722/57177
ISSN
2015 Impact Factor: 5.65
2015 SCImago Journal Rankings: 3.820
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVirtanen, IMen_HK
dc.contributor.authorSong, YQen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorAlaKokko, Len_HK
dc.contributor.authorKarppinen, Jen_HK
dc.contributor.authorHo, DWHen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorYip, SPen_HK
dc.contributor.authorLeong, JCYen_HK
dc.contributor.authorCheah, KSEen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorChan, Den_HK
dc.date.accessioned2010-04-12T01:28:22Z-
dc.date.available2010-04-12T01:28:22Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Medical Genetics, 2007, v. 44 n. 4, p. 285-288en_HK
dc.identifier.issn0022-2593en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57177-
dc.description.abstractBackground: Lumbar disc disease (LDD) is one of the leading causes of disability in the working-age population. A functional single-nucleotide polymorphism (SNP), +1184T→C, in exon 8 of the cartilage intermediate layer protein gene (CILP) was recently identified as a risk factor for LDD in the Japanese population (odds ratio (OR) 1.61, 95% CI 1.31 to 1.98), with implications for impaired transforming growth factorβ1 signalling. Aim: To validate this finding in two different ethnic cohorts with LDD. Methods: This SNP and flanking SNPs were analysed in 243 Finnish patients with symptoms of LDD and 259 controls, and in 348 Chinese subjects with MRI-defined LDD and 343 controls. Results and conclusion: The results showed no evidence of association in the Finnish (OR = 1.35, 95% CI 0.97 to 1.87; p = 0.14) or the Chinese (OR = 1.05, 95% CI 0.77 to 1.43; p = 0.71) samples, suggesting that cartilage intermediate layer protein gene is not a major risk factor for symptoms of LDD in Caucasians or in the general population that included individuals with or without symptoms.en_HK
dc.languageengen_HK
dc.publisherBMJ Group. The Journal's web site is located at http://jmg.bmj.com/en_HK
dc.relation.ispartofJournal of Medical Geneticsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Medical Genetics. Copyright © B M J Publishing Group.en_HK
dc.subject.meshExtracellular Matrix Proteins - genetics - physiologyen_HK
dc.subject.meshIntervertebral Disk Displacement - complications - epidemiology - geneticsen_HK
dc.subject.meshPolymorphism, Single Nucleotideen_HK
dc.subject.meshPyrophosphatases - genetics - physiologyen_HK
dc.subject.meshvertebral Disk DispLumbar Vertebraeen_HK
dc.titlePhenotypic and population differences in the association between CILP and lumbar disc diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-2593&volume=44&issue=4&spage=285&epage=288&date=2007&atitle=Phenotypic+and+population+differences+in+the+association+between+CILP+and+lumbar+disc+diseaseen_HK
dc.identifier.emailSong, YQ: songy@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_HK
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailChan, D: chand@hku.hken_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/jmg.2006.047076en_HK
dc.identifier.pmid17220213-
dc.identifier.pmcidPMC2598035-
dc.identifier.scopuseid_2-s2.0-34247093752en_HK
dc.identifier.hkuros128306-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247093752&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue4en_HK
dc.identifier.spage285en_HK
dc.identifier.epage288en_HK
dc.identifier.isiWOS:000245350500010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridVirtanen, IM=7102647897en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridAlaKokko, L=7005509196en_HK
dc.identifier.scopusauthoridKarppinen, J=7004560479en_HK
dc.identifier.scopusauthoridHo, DWH=23502006100en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridYip, SP=7102133673en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK

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