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Article: Maximum likelihood estimates of two-locus recombination fractions under some natural inequality restrictions

TitleMaximum likelihood estimates of two-locus recombination fractions under some natural inequality restrictions
Authors
Issue Date2008
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcgenet/
Citation
Bmc Genetics, 2008, v. 9 How to Cite?
AbstractBackground: The goal of linkage analysis is to determine the chromosomal location of the gene(s) for a trait of interest such as a common disease. Three-locus linkage analysis is an important case of multi-locus problems. Solutions can be found analytically for the case of triple backcross mating. However, in the present study of linkage analysis and gene mapping some natural inequality restrictions on parameters have not been considered sufficiently, when the maximum likelihood estimates (MLEs) of the two-locus recombination fractions are calculated. Results: In this paper, we present a study of estimating the two-locus recombination fractions for the phase-unknown triple backcross with two offspring in each family in the framework of some natural and necessary parameter restrictions. A restricted expectation-maximization (EM) algorithm, called REM is developed. We also consider some extensions in which the proposed REM can be taken as a unified method. Conclusion: Our simulation work suggests that the REM performs well in the estimation of recombination fractions and outperforms current method. We apply the proposed method to a published data set of mouse backcross families. © 2008 Zhou et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/57162
ISSN
2015 Impact Factor: 2.152
2015 SCImago Journal Rankings: 1.185
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorShi, NZen_HK
dc.contributor.authorFung, WKen_HK
dc.contributor.authorGuo, Jen_HK
dc.date.accessioned2010-04-12T01:27:55Z-
dc.date.available2010-04-12T01:27:55Z-
dc.date.issued2008en_HK
dc.identifier.citationBmc Genetics, 2008, v. 9en_HK
dc.identifier.issn1471-2156en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57162-
dc.description.abstractBackground: The goal of linkage analysis is to determine the chromosomal location of the gene(s) for a trait of interest such as a common disease. Three-locus linkage analysis is an important case of multi-locus problems. Solutions can be found analytically for the case of triple backcross mating. However, in the present study of linkage analysis and gene mapping some natural inequality restrictions on parameters have not been considered sufficiently, when the maximum likelihood estimates (MLEs) of the two-locus recombination fractions are calculated. Results: In this paper, we present a study of estimating the two-locus recombination fractions for the phase-unknown triple backcross with two offspring in each family in the framework of some natural and necessary parameter restrictions. A restricted expectation-maximization (EM) algorithm, called REM is developed. We also consider some extensions in which the proposed REM can be taken as a unified method. Conclusion: Our simulation work suggests that the REM performs well in the estimation of recombination fractions and outperforms current method. We apply the proposed method to a published data set of mouse backcross families. © 2008 Zhou et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcgenet/en_HK
dc.relation.ispartofBMC Geneticsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsB M C Genetics. Copyright © BioMed Central Ltd.en_HK
dc.subject.meshModels, Geneticen_HK
dc.subject.meshModels, Statisticalen_HK
dc.subject.meshRecombination, Geneticen_HK
dc.subject.meshLikelihood Functionsen_HK
dc.subject.meshLinkage Disequilibriumen_HK
dc.titleMaximum likelihood estimates of two-locus recombination fractions under some natural inequality restrictionsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1471-2156&volume=9 article no. 1&spage=&epage=&date=2008&atitle=Maximum+likelihood+estimates+of+two-locus+recombination+fractions+under+some+natural+inequality+restrictionsen_HK
dc.identifier.emailFung, WK: wingfung@hku.hken_HK
dc.identifier.authorityFung, WK=rp00696en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1186/1471-2156-9-1en_HK
dc.identifier.pmid18173855en_HK
dc.identifier.pmcidPMC2249595en_HK
dc.identifier.scopuseid_2-s2.0-39749105244en_HK
dc.identifier.hkuros149913-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39749105244&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.isiWOS:000253397000001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhou, Y=23669917100en_HK
dc.identifier.scopusauthoridShi, NZ=7004451232en_HK
dc.identifier.scopusauthoridFung, WK=13310399400en_HK
dc.identifier.scopusauthoridGuo, J=7404489563en_HK
dc.identifier.citeulike2194843-

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