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Article: Reaction time performance in ADHD: Improvement under fast-incentive condition and familial effects

TitleReaction time performance in ADHD: Improvement under fast-incentive condition and familial effects
Authors
Issue Date2007
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2007, v. 37 n. 12, p. 1703-1715 How to Cite?
Abstract
Background. Reaction time (RT) variability is one of the strongest findings to emerge in cognitive-experimental research of attention deficit hyperactivity disorder (ADHD). We set out to confirm the association between ADHD and slow and variable RTs and investigate the degree to which RT performance improves under fast event rate and incentives. Using a group familial correlation approach, we tested the hypothesis that there are shared familial effects on RT performance and ADHD. Method. A total of 144 ADHD combined-type probands, 125 siblings of the ADHD probands and 60 control participants, ages 6-18, performed a four-choice RT task with baseline and fast-incentive conditions. Results. ADHD was associated with slow and variable RTs, and with greater improvement in speed and RT variability from baseline to fast-incentive condition. RT performance showed shared familial influences with ADHD. Under the assumption that the familial effects represent genetic influences, the proportion of the phenotypic correlation due to shared familial influences was estimated as 60-70%. Conclusions. The data are inconsistent with models that consider RT variability as reflecting a stable cognitive deficit in ADHD, but instead emphasize the extent to which energetic or motivational factors can have a greater effect on RT performance in ADHD. The findings support the role of RT variability as an endophenotype mediating the link between genes and ADHD. © 2007 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/57157
ISSN
2013 Impact Factor: 5.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAndreou, Pen_HK
dc.contributor.authorNeale, BMen_HK
dc.contributor.authorChen, Wen_HK
dc.contributor.authorChristiansen, Hen_HK
dc.contributor.authorGabriels, Ien_HK
dc.contributor.authorHeise, Aen_HK
dc.contributor.authorMeidad, Sen_HK
dc.contributor.authorMuller, UCen_HK
dc.contributor.authorUebel, Hen_HK
dc.contributor.authorBanaschewski, Ten_HK
dc.contributor.authorManor, Ien_HK
dc.contributor.authorOades, Ren_HK
dc.contributor.authorRoeyers, Hen_HK
dc.contributor.authorRothenberger, Aen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorSteinhausen, HCen_HK
dc.contributor.authorAsherson, Pen_HK
dc.contributor.authorKuntsi, Jen_HK
dc.date.accessioned2010-04-12T01:27:37Z-
dc.date.available2010-04-12T01:27:37Z-
dc.date.issued2007en_HK
dc.identifier.citationPsychological Medicine, 2007, v. 37 n. 12, p. 1703-1715en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57157-
dc.description.abstractBackground. Reaction time (RT) variability is one of the strongest findings to emerge in cognitive-experimental research of attention deficit hyperactivity disorder (ADHD). We set out to confirm the association between ADHD and slow and variable RTs and investigate the degree to which RT performance improves under fast event rate and incentives. Using a group familial correlation approach, we tested the hypothesis that there are shared familial effects on RT performance and ADHD. Method. A total of 144 ADHD combined-type probands, 125 siblings of the ADHD probands and 60 control participants, ages 6-18, performed a four-choice RT task with baseline and fast-incentive conditions. Results. ADHD was associated with slow and variable RTs, and with greater improvement in speed and RT variability from baseline to fast-incentive condition. RT performance showed shared familial influences with ADHD. Under the assumption that the familial effects represent genetic influences, the proportion of the phenotypic correlation due to shared familial influences was estimated as 60-70%. Conclusions. The data are inconsistent with models that consider RT variability as reflecting a stable cognitive deficit in ADHD, but instead emphasize the extent to which energetic or motivational factors can have a greater effect on RT performance in ADHD. The findings support the role of RT variability as an endophenotype mediating the link between genes and ADHD. © 2007 Cambridge University Press.en_HK
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAttention Deficit Disorder with Hyperactivity - diagnosis - genetics -en_HK
dc.subject.meshMotivationen_HK
dc.subject.meshReaction Time - geneticsen_HK
dc.subject.meshGenetic Predisposition to Disease - geneticsen_HK
dc.subject.meshModels, Geneticen_HK
dc.titleReaction time performance in ADHD: Improvement under fast-incentive condition and familial effectsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0033-2917&volume=37&issue=12&spage=1703&epage=1715&date=2007&atitle=Reaction+time+performance+in+ADHD:+improvement+under+fast-incentive+condition+and+familial+effectsen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1017/S0033291707000815en_HK
dc.identifier.pmid17537284en_HK
dc.identifier.scopuseid_2-s2.0-36048957548en_HK
dc.identifier.hkuros151600-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36048957548&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1703en_HK
dc.identifier.epage1715en_HK
dc.identifier.isiWOS:000251887600003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAndreou, P=14719214000en_HK
dc.identifier.scopusauthoridNeale, BM=7003484514en_HK
dc.identifier.scopusauthoridChen, W=35975528400en_HK
dc.identifier.scopusauthoridChristiansen, H=8954661000en_HK
dc.identifier.scopusauthoridGabriels, I=24072954900en_HK
dc.identifier.scopusauthoridHeise, A=7006439396en_HK
dc.identifier.scopusauthoridMeidad, S=22980430200en_HK
dc.identifier.scopusauthoridMuller, UC=12242861600en_HK
dc.identifier.scopusauthoridUebel, H=22982364200en_HK
dc.identifier.scopusauthoridBanaschewski, T=6603935963en_HK
dc.identifier.scopusauthoridManor, I=6701576599en_HK
dc.identifier.scopusauthoridOades, R=7006782221en_HK
dc.identifier.scopusauthoridRoeyers, H=6701645061en_HK
dc.identifier.scopusauthoridRothenberger, A=7005835367en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridSteinhausen, HC=7102832892en_HK
dc.identifier.scopusauthoridAsherson, P=35402700900en_HK
dc.identifier.scopusauthoridKuntsi, J=6603162889en_HK
dc.identifier.citeulike9933955-

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