Article: Reaction time performance in ADHD: Improvement under fast-incentive condition and familial effects

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TitleReaction time performance in ADHD: Improvement under fast-incentive condition and familial effects
AuthorsAndreou, P2
Neale, BM2
Chen, W2
Christiansen, H5
Gabriels, I
Heise, A3
Meidad, S1
Muller, UC6
Uebel, H3
Banaschewski, T3 4
Manor, I1
Oades, R5
Roeyers, H
Rothenberger, A3
Sham, P2
Steinhausen, HC6
Asherson, P2
Kuntsi, J2
Issue Date2007
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
CitationPsychological Medicine, 2007, v. 37 n. 12, p. 1703-1715 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291707000815
AbstractBackground. Reaction time (RT) variability is one of the strongest findings to emerge in cognitive-experimental research of attention deficit hyperactivity disorder (ADHD). We set out to confirm the association between ADHD and slow and variable RTs and investigate the degree to which RT performance improves under fast event rate and incentives. Using a group familial correlation approach, we tested the hypothesis that there are shared familial effects on RT performance and ADHD. Method. A total of 144 ADHD combined-type probands, 125 siblings of the ADHD probands and 60 control participants, ages 6-18, performed a four-choice RT task with baseline and fast-incentive conditions. Results. ADHD was associated with slow and variable RTs, and with greater improvement in speed and RT variability from baseline to fast-incentive condition. RT performance showed shared familial influences with ADHD. Under the assumption that the familial effects represent genetic influences, the proportion of the phenotypic correlation due to shared familial influences was estimated as 60-70%. Conclusions. The data are inconsistent with models that consider RT variability as reflecting a stable cognitive deficit in ADHD, but instead emphasize the extent to which energetic or motivational factors can have a greater effect on RT performance in ADHD. The findings support the role of RT variability as an endophenotype mediating the link between genes and ADHD. © 2007 Cambridge University Press.
ISSN0033-2917
2011 Impact Factor: 6.159
2011 SCImago Journal Rankings: 0.269
DOIhttp://dx.doi.org/10.1017/S0033291707000815
ISI Accession Number IDWOS:000251887600003
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorAndreou, P
dc.contributor.authorNeale, BM
dc.contributor.authorChen, W
dc.contributor.authorChristiansen, H
dc.contributor.authorGabriels, I
dc.contributor.authorHeise, A
dc.contributor.authorMeidad, S
dc.contributor.authorMuller, UC
dc.contributor.authorUebel, H
dc.contributor.authorBanaschewski, T
dc.contributor.authorManor, I
dc.contributor.authorOades, R
dc.contributor.authorRoeyers, H
dc.contributor.authorRothenberger, A
dc.contributor.authorSham, P
dc.contributor.authorSteinhausen, HC
dc.contributor.authorAsherson, P
dc.contributor.authorKuntsi, J
dc.date.accessioned2010-04-12T01:27:37Z
dc.date.available2010-04-12T01:27:37Z
dc.date.issued2007
dc.description.abstractBackground. Reaction time (RT) variability is one of the strongest findings to emerge in cognitive-experimental research of attention deficit hyperactivity disorder (ADHD). We set out to confirm the association between ADHD and slow and variable RTs and investigate the degree to which RT performance improves under fast event rate and incentives. Using a group familial correlation approach, we tested the hypothesis that there are shared familial effects on RT performance and ADHD. Method. A total of 144 ADHD combined-type probands, 125 siblings of the ADHD probands and 60 control participants, ages 6-18, performed a four-choice RT task with baseline and fast-incentive conditions. Results. ADHD was associated with slow and variable RTs, and with greater improvement in speed and RT variability from baseline to fast-incentive condition. RT performance showed shared familial influences with ADHD. Under the assumption that the familial effects represent genetic influences, the proportion of the phenotypic correlation due to shared familial influences was estimated as 60-70%. Conclusions. The data are inconsistent with models that consider RT variability as reflecting a stable cognitive deficit in ADHD, but instead emphasize the extent to which energetic or motivational factors can have a greater effect on RT performance in ADHD. The findings support the role of RT variability as an endophenotype mediating the link between genes and ADHD. © 2007 Cambridge University Press.
dc.description.naturepublished_or_final_version
dc.identifier.citationPsychological Medicine, 2007, v. 37 n. 12, p. 1703-1715 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291707000815
dc.identifier.citeulike9933955
dc.identifier.doihttp://dx.doi.org/10.1017/S0033291707000815
dc.identifier.epage1715
dc.identifier.hkuros151600
dc.identifier.isiWOS:000251887600003
dc.identifier.issn0033-2917
2011 Impact Factor: 6.159
2011 SCImago Journal Rankings: 0.269
dc.identifier.issue12
dc.identifier.openurl
dc.identifier.pmid17537284
dc.identifier.scopuseid_2-s2.0-36048957548
dc.identifier.spage1703
dc.identifier.urihttp://hdl.handle.net/10722/57157
dc.identifier.volume37
dc.languageeng
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
dc.publisher.placeUnited Kingdom
dc.relation.ispartofPsychological Medicine
dc.relation.referencesReferences in Scopus
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshAttention Deficit Disorder with Hyperactivity - diagnosis - genetics -
dc.subject.meshMotivation
dc.subject.meshReaction Time - genetics
dc.subject.meshGenetic Predisposition to Disease - genetics
dc.subject.meshModels, Genetic
dc.titleReaction time performance in ADHD: Improvement under fast-incentive condition and familial effects
dc.typeArticle
Author Affiliations
  1. Geha Mental Health Center
  2. Medical Research Council
  3. Universität Göttingen
  4. Zentralinstitut für Seelische Gesundheit
  5. Rheinische Kliniken Essen
  6. Universität Zürich