Article: Sjögren's syndrome sufferers have increased oral yeast levels despite regular dental care

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TitleSjögren's syndrome sufferers have increased oral yeast levels despite regular dental care
AuthorsLeung, KCM1
McMillan, AS1
Cheung, BPK1
Leung, WK1 2
KeywordsCandida albicans
Candidiasis, oral
Dental plaque
Mycology
Sjögren's syndrome
Xerostomia
Issue Date2008
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
CitationOral Diseases, 2008, v. 14 n. 2, p. 163-173 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1601-0825.2007.01368.x
AbstractAim: To investigate the prevalence and quantity of oral yeasts and their association with oral candidiasis in Sjögren's syndrome (SS) patients receiving regular dental care. Materials and methods: Yeasts in oral rinse and full-mouth supra-gingival plaque samples from 25 primary SS, 27 secondary SS and 29 control subjects were selectively cultured. All yeasts except single-species isolates were genotyped using pulsed field gel electrophoresis (PFGE). Results: Ten (19%) SS sufferers had symptomless candidiasis. SS subjects had a higher prevalence (73%vs 7%) and quantity of yeasts than controls in both oral rinse and plaque samples (P < 0.05). The prevalence of yeasts in plaque was associated with candidiasis regardless of denture wearing (P ≤ 0.04). Candida albicans was the predominant yeast isolated. PFGE showed 20 (66% of total) C. albicans isolate pairs, i.e. C. albicans species isolated from plaque and oral rinse samples of the same individual, were of closely related genetic clonal types (P < 0.01). Conclusions: Despite effective oral hygiene, more SS subjects than controls had detectable levels of oral yeasts and their presence in supra-gingival plaque was associated with candidiasis. Candida albicans colonized supra-gingival biofilm even in well-maintained SS individuals, posing a challenge to the control of oral candidiasis. © 2007 The Authors.
ISSN1354-523X
2011 Impact Factor: 2.495
2011 SCImago Journal Rankings: 0.168
DOIhttp://dx.doi.org/10.1111/j.1601-0825.2007.01368.x
ISI Accession Number IDWOS:000253482000011
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLeung, KCM
dc.contributor.authorMcMillan, AS
dc.contributor.authorCheung, BPK
dc.contributor.authorLeung, WK
dc.date.accessioned2009-08-06T03:37:52Z
dc.date.available2009-08-06T03:37:52Z
dc.date.issued2008
dc.description.abstractAim: To investigate the prevalence and quantity of oral yeasts and their association with oral candidiasis in Sjögren's syndrome (SS) patients receiving regular dental care. Materials and methods: Yeasts in oral rinse and full-mouth supra-gingival plaque samples from 25 primary SS, 27 secondary SS and 29 control subjects were selectively cultured. All yeasts except single-species isolates were genotyped using pulsed field gel electrophoresis (PFGE). Results: Ten (19%) SS sufferers had symptomless candidiasis. SS subjects had a higher prevalence (73%vs 7%) and quantity of yeasts than controls in both oral rinse and plaque samples (P < 0.05). The prevalence of yeasts in plaque was associated with candidiasis regardless of denture wearing (P ≤ 0.04). Candida albicans was the predominant yeast isolated. PFGE showed 20 (66% of total) C. albicans isolate pairs, i.e. C. albicans species isolated from plaque and oral rinse samples of the same individual, were of closely related genetic clonal types (P < 0.01). Conclusions: Despite effective oral hygiene, more SS subjects than controls had detectable levels of oral yeasts and their presence in supra-gingival plaque was associated with candidiasis. Candida albicans colonized supra-gingival biofilm even in well-maintained SS individuals, posing a challenge to the control of oral candidiasis. © 2007 The Authors.
dc.description.naturepostprint
dc.identifier.citationOral Diseases, 2008, v. 14 n. 2, p. 163-173 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1601-0825.2007.01368.x
dc.identifier.citeulike2436620
dc.identifier.doihttp://dx.doi.org/10.1111/j.1601-0825.2007.01368.x
dc.identifier.epage173
dc.identifier.hkuros140750
dc.identifier.isiWOS:000253482000011
dc.identifier.issn1354-523X
2011 Impact Factor: 2.495
2011 SCImago Journal Rankings: 0.168
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid18302677
dc.identifier.scopuseid_2-s2.0-39749125122
dc.identifier.spage163
dc.identifier.urihttp://hdl.handle.net/10722/55451
dc.identifier.volume14
dc.languageeng
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
dc.publisher.placeUnited States
dc.relation.ispartofOral Diseases
dc.relation.referencesReferences in Scopus
dc.rightsThe definitive version is available at www.blackwell-synergy.com
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshCandidiasis, Oral - complications - diagnosis - prevention & control
dc.subject.meshSjogren's Syndrome - classification - complications - microbiology
dc.subject.meshOral Hygiene - methods
dc.subject.meshDental Plaque - microbiology
dc.subject.meshCandida - isolation & purification
dc.subjectCandida albicans
dc.subjectCandidiasis, oral
dc.subjectDental plaque
dc.subjectMycology
dc.subjectSjögren's syndrome
dc.subjectXerostomia
dc.titleSjögren's syndrome sufferers have increased oral yeast levels despite regular dental care
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Prince Philip Dental Hospital