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Article: Sjögren's syndrome sufferers have increased oral yeast levels despite regular dental care

TitleSjögren's syndrome sufferers have increased oral yeast levels despite regular dental care
Authors
KeywordsCandida albicans
Candidiasis, oral
Dental plaque
Mycology
Sjögren's syndrome
Xerostomia
Issue Date2008
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
Citation
Oral Diseases, 2008, v. 14 n. 2, p. 163-173 How to Cite?
Abstract
Aim: To investigate the prevalence and quantity of oral yeasts and their association with oral candidiasis in Sjögren's syndrome (SS) patients receiving regular dental care. Materials and methods: Yeasts in oral rinse and full-mouth supra-gingival plaque samples from 25 primary SS, 27 secondary SS and 29 control subjects were selectively cultured. All yeasts except single-species isolates were genotyped using pulsed field gel electrophoresis (PFGE). Results: Ten (19%) SS sufferers had symptomless candidiasis. SS subjects had a higher prevalence (73%vs 7%) and quantity of yeasts than controls in both oral rinse and plaque samples (P < 0.05). The prevalence of yeasts in plaque was associated with candidiasis regardless of denture wearing (P ≤ 0.04). Candida albicans was the predominant yeast isolated. PFGE showed 20 (66% of total) C. albicans isolate pairs, i.e. C. albicans species isolated from plaque and oral rinse samples of the same individual, were of closely related genetic clonal types (P < 0.01). Conclusions: Despite effective oral hygiene, more SS subjects than controls had detectable levels of oral yeasts and their presence in supra-gingival plaque was associated with candidiasis. Candida albicans colonized supra-gingival biofilm even in well-maintained SS individuals, posing a challenge to the control of oral candidiasis. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/55451
ISSN
2013 Impact Factor: 2.404
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Prince Philip Dental Hospital
DC FieldValueLanguage
dc.contributor.authorLeung, KCMen_HK
dc.contributor.authorMcMillan, ASen_HK
dc.contributor.authorCheung, BPKen_HK
dc.contributor.authorLeung, WKen_HK
dc.date.accessioned2009-08-06T03:37:52Z-
dc.date.available2009-08-06T03:37:52Z-
dc.date.issued2008en_HK
dc.identifier.citationOral Diseases, 2008, v. 14 n. 2, p. 163-173en_HK
dc.identifier.issn1354-523Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/55451-
dc.description.abstractAim: To investigate the prevalence and quantity of oral yeasts and their association with oral candidiasis in Sjögren's syndrome (SS) patients receiving regular dental care. Materials and methods: Yeasts in oral rinse and full-mouth supra-gingival plaque samples from 25 primary SS, 27 secondary SS and 29 control subjects were selectively cultured. All yeasts except single-species isolates were genotyped using pulsed field gel electrophoresis (PFGE). Results: Ten (19%) SS sufferers had symptomless candidiasis. SS subjects had a higher prevalence (73%vs 7%) and quantity of yeasts than controls in both oral rinse and plaque samples (P < 0.05). The prevalence of yeasts in plaque was associated with candidiasis regardless of denture wearing (P ≤ 0.04). Candida albicans was the predominant yeast isolated. PFGE showed 20 (66% of total) C. albicans isolate pairs, i.e. C. albicans species isolated from plaque and oral rinse samples of the same individual, were of closely related genetic clonal types (P < 0.01). Conclusions: Despite effective oral hygiene, more SS subjects than controls had detectable levels of oral yeasts and their presence in supra-gingival plaque was associated with candidiasis. Candida albicans colonized supra-gingival biofilm even in well-maintained SS individuals, posing a challenge to the control of oral candidiasis. © 2007 The Authors.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1en_HK
dc.relation.ispartofOral Diseasesen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.comen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCandida albicansen_HK
dc.subjectCandidiasis, oralen_HK
dc.subjectDental plaqueen_HK
dc.subjectMycologyen_HK
dc.subjectSjögren's syndromeen_HK
dc.subjectXerostomiaen_HK
dc.subject.meshCandidiasis, Oral - complications - diagnosis - prevention & controlen_HK
dc.subject.meshSjogren's Syndrome - classification - complications - microbiologyen_HK
dc.subject.meshOral Hygiene - methodsen_HK
dc.subject.meshDental Plaque - microbiologyen_HK
dc.subject.meshCandida - isolation & purificationen_HK
dc.titleSjögren's syndrome sufferers have increased oral yeast levels despite regular dental careen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1354-523X&volume=14&issue=2&spage=163&epage=173&date=2008&atitle=Sjögren’s+syndrome+sufferers+have+increased+oral+yeast+levels+despite+regular+dental+careen_HK
dc.identifier.emailLeung, KCM: kcmleung@hkucc.hku.hken_HK
dc.identifier.emailMcMillan, AS: annemcmillan@hku.hken_HK
dc.identifier.emailLeung, WK: ewkleung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, KCM=rp00032en_HK
dc.identifier.authorityMcMillan, AS=rp00014en_HK
dc.identifier.authorityLeung, WK=rp00019en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1111/j.1601-0825.2007.01368.xen_HK
dc.identifier.pmid18302677en_HK
dc.identifier.scopuseid_2-s2.0-39749125122en_HK
dc.identifier.hkuros140750en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39749125122&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue2en_HK
dc.identifier.spage163en_HK
dc.identifier.epage173en_HK
dc.identifier.eissn1601-0825-
dc.identifier.isiWOS:000253482000011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, KCM=26221830300en_HK
dc.identifier.scopusauthoridMcMillan, AS=7102843317en_HK
dc.identifier.scopusauthoridCheung, BPK=7103294773en_HK
dc.identifier.scopusauthoridLeung, WK=25224691800en_HK
dc.identifier.citeulike2436620-

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