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Article: Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus

TitlePhospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus
Authors
Issue Date2007
PublisherSociety for General Microbiology. The Journal's web site is located at http://jmm.sgmjournals.org
Citation
Journal Of Medical Microbiology, 2007, v. 56 n. 10, p. 1393-1398 How to Cite?
AbstractThe aim of this study was to biotype and characterize phospholipase, proteinase and haemolytic activities of oral Candida albicans isolates from 210 Chinese patients with type 2 diabetes mellitus (DM) and 210 age- and sex-matched healthy controls. Seventy-six and 50 C. albicans isolates were obtained from type 2 DM patients and controls, respectively, using the oral rinse technique. The isolates were characterized with a biotyping system based on enzyme profiles, carbohydrate assimilation patterns and boric acid resistance of the yeasts, and the isolates were further tested for in vitro phospholipase, proteinase and haemolytic activities. The major biotypes of C. albicans isolates from the type 2 DM and control groups were A1R (42.1 %) and J1R (36.0%), respectively. Significantly higher proteinase and haemolytic activities were found in the isolates from the type 2 DM group (P<0.05). Proteinase activity was higher in isolates from patients with ≥ 10 years of DM history than those with <10 years (P<0.05). Haemolytic activity was significantly higher in isolates from female DM patients than in those from male counterparts (P<0.05). These data provide evidence of increased extracellular enzyme activity in Candida isolates taken from DM patients. © 2007 SGM.
Persistent Identifierhttp://hdl.handle.net/10722/55436
ISSN
2015 Impact Factor: 2.269
2015 SCImago Journal Rankings: 1.060
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, CSPen_HK
dc.contributor.authorChu, FCSen_HK
dc.contributor.authorLeung, WKen_HK
dc.contributor.authorJin, LJen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.contributor.authorSiu, SCen_HK
dc.date.accessioned2009-08-06T03:37:03Z-
dc.date.available2009-08-06T03:37:03Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Medical Microbiology, 2007, v. 56 n. 10, p. 1393-1398en_HK
dc.identifier.issn0022-2615en_HK
dc.identifier.urihttp://hdl.handle.net/10722/55436-
dc.description.abstractThe aim of this study was to biotype and characterize phospholipase, proteinase and haemolytic activities of oral Candida albicans isolates from 210 Chinese patients with type 2 diabetes mellitus (DM) and 210 age- and sex-matched healthy controls. Seventy-six and 50 C. albicans isolates were obtained from type 2 DM patients and controls, respectively, using the oral rinse technique. The isolates were characterized with a biotyping system based on enzyme profiles, carbohydrate assimilation patterns and boric acid resistance of the yeasts, and the isolates were further tested for in vitro phospholipase, proteinase and haemolytic activities. The major biotypes of C. albicans isolates from the type 2 DM and control groups were A1R (42.1 %) and J1R (36.0%), respectively. Significantly higher proteinase and haemolytic activities were found in the isolates from the type 2 DM group (P<0.05). Proteinase activity was higher in isolates from patients with ≥ 10 years of DM history than those with <10 years (P<0.05). Haemolytic activity was significantly higher in isolates from female DM patients than in those from male counterparts (P<0.05). These data provide evidence of increased extracellular enzyme activity in Candida isolates taken from DM patients. © 2007 SGM.en_HK
dc.languageengen_HK
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://jmm.sgmjournals.orgen_HK
dc.relation.ispartofJournal of Medical Microbiologyen_HK
dc.rightsThis is an author manuscript that has been accepted for publication in Journal of Medical Microbiology, copyright Society for General Microbiology, but has not been copy-edited, formatted or proofed. Cite this article as appearing in Journal of Medical Microbiology. This version of the manuscript may not be duplicated or reproduced, other than for personal use or within the rule of 'Fair Use of Copyrighted Materials' (section 17, Title 17, US Code), without permission from the copyright owner, Society for General Microbiology. The Society for General Microbiology disclaims any responsibility or liability for errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final copy-edited, published article, which is the version of record, can be found at http://jmm.sgmjournals.org, and is freely available without a subscription.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCandida albicans - enzymology - isolation & purificationen_HK
dc.subject.meshDiabetes Mellitus, Type 2 - complicationsen_HK
dc.subject.meshHemolysin Proteins - biosynthesisen_HK
dc.subject.meshPeptide Hydrolases - biosynthesisen_HK
dc.subject.meshCandidiasis - microbiologyen_HK
dc.titlePhospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-2615&volume=56&issue=10&spage=1393&epage=1398&date=2007&atitle=Phospholipase,+proteinase+and+haemolytic+activities+of+Candida+albicans+isolated+from+oral+cavities+of+patients+with+type+2+diabetes+mellitusen_HK
dc.identifier.emailTsang, CSP: csptsang@hkucc.hku.hken_HK
dc.identifier.emailChu, FCS: cschu@hkucc.hku.hken_HK
dc.identifier.emailLeung, WK: ewkleung@hkucc.hku.hken_HK
dc.identifier.emailJin, LJ: ljjin@hkucc.hku.hken_HK
dc.identifier.emailSamaranayake, LP: lakshman@hku.hken_HK
dc.identifier.authorityTsang, CSP=rp00026en_HK
dc.identifier.authorityChu, FCS=rp00035en_HK
dc.identifier.authorityLeung, WK=rp00019en_HK
dc.identifier.authorityJin, LJ=rp00028en_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1099/jmm.0.47303-0en_HK
dc.identifier.pmid17893179en_HK
dc.identifier.scopuseid_2-s2.0-36148979370en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36148979370&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume56en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1393en_HK
dc.identifier.epage1398en_HK
dc.identifier.eissn1473-5644-
dc.identifier.isiWOS:000250538100021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTsang, CSP=7202936002en_HK
dc.identifier.scopusauthoridChu, FCS=7201881096en_HK
dc.identifier.scopusauthoridLeung, WK=25224691800en_HK
dc.identifier.scopusauthoridJin, LJ=7403328850en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.scopusauthoridSiu, SC=8592047000en_HK

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