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Article: Intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: A prospective study on disease control and preservation of salivary function

TitleIntensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: A prospective study on disease control and preservation of salivary function
Authors
KeywordsIntensity-modulated radiotherapy
Nasopharyngeal carcinoma
Parotid sparing
Salivary flow
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2004, v. 101 n. 7, p. 1584-1593 How to Cite?
AbstractBACKGROUND. Xerostomia is a uniform complication after radiotherapy (RT) for nasopharyngeal carcinoma (NPC). Dosimetric studies suggested that intensity-modulated RT (IMRT) can spare part of the parotid glands from high-dose radiation. Disease control and salivary function after IMRT for early-stage NPC was studied prospectively. METHODS. Thirty-three patients with Ti,N0-N1,M0 NPC were treated with IMRT from 2000 to 2002. The prescribed dose was 68-70 grays (Gy) in 34 fractions to gross tumor volume, 64-68 Gy to the planning target volume, and 70 Gy to enlarged cervical lymph nodes. Nineteen patients had stimulated whole salivary (SWS) flow assessment and stimulated parotid salivary (SPS) flow assessment at baseline and at 2 months, 6 months, 12 months, 18 months, and 24 months after the completion of IMRT. RESULTS. At a median follow-up of 2 years, only 1 neck failure was observed. The 2-year and 3-year local control, distant metastases-free, and overall survival rates all were 100%. The lymph node control and progression-free survival rates were 100% at 2 years and 92.3% at 3 years, respectively. The average mean dose to the parotid gland was 38.8 Gy. The SWS and SPS flow showed continuous recovery: 60% and 47.1% of patients recovered at least 25% of their baseline SPS flow and SWS flow, respectively, at 1 year after completion of IMRT, and the proportions rose to 85.7% and 71.4%, respectively, by 2 years. The pH and buffering capacity of saliva also improved with time. CONCLUSIONS. Parotid-sparing IMRT achieved good locoregional control, and there was continuous recovery of salivary flow, pH, and buffering capacity in the first 2 years after IMRT in patients with NPC. © 2004 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/55435
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorPow, EHNen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorMcMillan, ASen_HK
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorLeung, WKen_HK
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorCheng, ACKen_HK
dc.contributor.authorWu, PMen_HK
dc.contributor.authorAu, GKHen_HK
dc.date.accessioned2009-08-06T03:37:00Z-
dc.date.available2009-08-06T03:37:00Z-
dc.date.issued2004en_HK
dc.identifier.citationCancer, 2004, v. 101 n. 7, p. 1584-1593en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/55435-
dc.description.abstractBACKGROUND. Xerostomia is a uniform complication after radiotherapy (RT) for nasopharyngeal carcinoma (NPC). Dosimetric studies suggested that intensity-modulated RT (IMRT) can spare part of the parotid glands from high-dose radiation. Disease control and salivary function after IMRT for early-stage NPC was studied prospectively. METHODS. Thirty-three patients with Ti,N0-N1,M0 NPC were treated with IMRT from 2000 to 2002. The prescribed dose was 68-70 grays (Gy) in 34 fractions to gross tumor volume, 64-68 Gy to the planning target volume, and 70 Gy to enlarged cervical lymph nodes. Nineteen patients had stimulated whole salivary (SWS) flow assessment and stimulated parotid salivary (SPS) flow assessment at baseline and at 2 months, 6 months, 12 months, 18 months, and 24 months after the completion of IMRT. RESULTS. At a median follow-up of 2 years, only 1 neck failure was observed. The 2-year and 3-year local control, distant metastases-free, and overall survival rates all were 100%. The lymph node control and progression-free survival rates were 100% at 2 years and 92.3% at 3 years, respectively. The average mean dose to the parotid gland was 38.8 Gy. The SWS and SPS flow showed continuous recovery: 60% and 47.1% of patients recovered at least 25% of their baseline SPS flow and SWS flow, respectively, at 1 year after completion of IMRT, and the proportions rose to 85.7% and 71.4%, respectively, by 2 years. The pH and buffering capacity of saliva also improved with time. CONCLUSIONS. Parotid-sparing IMRT achieved good locoregional control, and there was continuous recovery of salivary flow, pH, and buffering capacity in the first 2 years after IMRT in patients with NPC. © 2004 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectIntensity-modulated radiotherapyen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectParotid sparingen_HK
dc.subjectSalivary flowen_HK
dc.subject.meshNasopharyngeal Neoplasms - mortality - radiotherapyen_HK
dc.subject.meshParotid Gland - physiology - radiation effectsen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRadiotherapy Dosageen_HK
dc.subject.meshSurvival Rateen_HK
dc.titleIntensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: A prospective study on disease control and preservation of salivary functionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=101&issue=7&spage=1584&epage=1593&date=2004&atitle=Intensity-Modulated+Radiotherapy+for+Early-Stage+Nasopharyngeal+Carcinoma:+A+Prospective+Study+on+Disease+Control+and+Preservation+of+Salivary+Functionen_HK
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_HK
dc.identifier.emailPow, EHN:ehnpow@hku.hken_HK
dc.identifier.emailMcMillan, AS:annemcmillan@hku.hken_HK
dc.identifier.emailLeung, WK:ewkleung@hkucc.hku.hken_HK
dc.identifier.emailChua, DTT:dttchua@hkucc.hku.hken_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityPow, EHN=rp00030en_HK
dc.identifier.authorityMcMillan, AS=rp00014en_HK
dc.identifier.authorityLeung, WK=rp00019en_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1002/cncr.20552en_HK
dc.identifier.pmid15378492-
dc.identifier.scopuseid_2-s2.0-4844223514en_HK
dc.identifier.hkuros101264-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4844223514&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume101en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1584en_HK
dc.identifier.epage1593en_HK
dc.identifier.isiWOS:000223992300015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600-
dc.identifier.scopusauthoridPow, EHN=6603825799-
dc.identifier.scopusauthoridSham, JST=7101655565-
dc.identifier.scopusauthoridMcMillan, AS=7102843317-
dc.identifier.scopusauthoridLeung, LHT=7202048113-
dc.identifier.scopusauthoridLeung, WK=25224691800-
dc.identifier.scopusauthoridChua, DTT=7006773480-
dc.identifier.scopusauthoridCheng, ACK=36055097300-
dc.identifier.scopusauthoridWu, PM=8663653900-
dc.identifier.scopusauthoridAu, GKH=7003748615-

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