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Article: New statistical method for analyzing time to first seizure: Example using data comparing carbamazepine and valproate monotherapy

TitleNew statistical method for analyzing time to first seizure: Example using data comparing carbamazepine and valproate monotherapy
Authors
KeywordsCarbamazepine
Epilepsy
Sodium valproate
Issue Date2007
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.epilepsia.com/
Citation
Epilepsia, 2007, v. 48 n. 6, p. 1173-1178 How to Cite?
AbstractIntroduction: Time to first seizure is a common outcome in antiepileptic drug (AED) studies. Previous studies have typically failed to find statistically significant differences between carbamazepine (CBZ) and valproate (VPS). We re-analyzed a meta-analysis comparing CBZ and VPS monotherapy with new powerful statistical methods that incorporate baseline seizure rate information. Methods: Individual patient data were available on 1,265 patients from a meta-analysis of five trials. The outcome measure was time to first seizure after randomization, adjusted for background variables and baseline seizure rate. Results: We found strong evidence of an interaction between treatment and epilepsy type, and between treatment and age. For generalized onset seizures, VPS was statistically significantly better than CBZ: VPS delayed the first seizure after treatment 58%, 52%, 44%, and 36% longer than CBZ for individuals aged 10, 20, 30, or 40, respectively. For partial onset seizures in individuals older than 30, CBZ was significantly better then VPS; CBZ delayed the time to first seizure by 9%, 25%, 44%, and 66% longer than VPS for individuals aged 20, 30, 40, or 50, respectively. Conclusion: The results show clear age-varying differences between the effectiveness of CBZ and VPS for generalized onset and partial onset seizures, which have not been identified in previous studies using standard statistical methods. In future trials of AED monotherapy or add-on where time to first or Nth seizure is an outcome, methodology that can incorporate baseline seizure rate information would allow more powerful comparisons between treatments or between treatment and placebo. © 2007 International League Against Epilepsy.
Persistent Identifierhttp://hdl.handle.net/10722/54271
ISSN
2015 Impact Factor: 4.706
2015 SCImago Journal Rankings: 2.579
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCowling, BJen_HK
dc.contributor.authorShaw, JEHen_HK
dc.contributor.authorHutton, JLen_HK
dc.contributor.authorMarson, AGen_HK
dc.date.accessioned2009-04-03T07:41:44Z-
dc.date.available2009-04-03T07:41:44Z-
dc.date.issued2007en_HK
dc.identifier.citationEpilepsia, 2007, v. 48 n. 6, p. 1173-1178en_HK
dc.identifier.issn0013-9580en_HK
dc.identifier.urihttp://hdl.handle.net/10722/54271-
dc.description.abstractIntroduction: Time to first seizure is a common outcome in antiepileptic drug (AED) studies. Previous studies have typically failed to find statistically significant differences between carbamazepine (CBZ) and valproate (VPS). We re-analyzed a meta-analysis comparing CBZ and VPS monotherapy with new powerful statistical methods that incorporate baseline seizure rate information. Methods: Individual patient data were available on 1,265 patients from a meta-analysis of five trials. The outcome measure was time to first seizure after randomization, adjusted for background variables and baseline seizure rate. Results: We found strong evidence of an interaction between treatment and epilepsy type, and between treatment and age. For generalized onset seizures, VPS was statistically significantly better than CBZ: VPS delayed the first seizure after treatment 58%, 52%, 44%, and 36% longer than CBZ for individuals aged 10, 20, 30, or 40, respectively. For partial onset seizures in individuals older than 30, CBZ was significantly better then VPS; CBZ delayed the time to first seizure by 9%, 25%, 44%, and 66% longer than VPS for individuals aged 20, 30, 40, or 50, respectively. Conclusion: The results show clear age-varying differences between the effectiveness of CBZ and VPS for generalized onset and partial onset seizures, which have not been identified in previous studies using standard statistical methods. In future trials of AED monotherapy or add-on where time to first or Nth seizure is an outcome, methodology that can incorporate baseline seizure rate information would allow more powerful comparisons between treatments or between treatment and placebo. © 2007 International League Against Epilepsy.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.epilepsia.com/en_HK
dc.relation.ispartofEpilepsiaen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThe definitive version is available at www.blackwell-synergy.comen_HK
dc.subjectCarbamazepineen_HK
dc.subjectEpilepsyen_HK
dc.subjectSodium valproateen_HK
dc.subject.meshAnticonvulsants - therapeutic useen_HK
dc.subject.meshCarbamazepine - therapeutic useen_HK
dc.subject.meshData Interpretation, Statisticalen_HK
dc.subject.meshEpilepsies, Partial - diagnosis - drug therapyen_HK
dc.subject.meshEpilepsy - diagnosis - drug therapyen_HK
dc.titleNew statistical method for analyzing time to first seizure: Example using data comparing carbamazepine and valproate monotherapyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0013-9580&volume=48&issue=6&spage=1173&epage=1178&date=2007&atitle=New+statistical+method+for+analyzing+time+to+first+seizure:+example+using+data+comparing+carbamazepine+and+valproate+monotherapyen_HK
dc.identifier.emailCowling, BJ:bcowling@hku.hken_HK
dc.identifier.authorityCowling, BJ=rp01326en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1111/j.1528-1167.2007.01036.xen_HK
dc.identifier.pmid17553118-
dc.identifier.scopuseid_2-s2.0-34249781993en_HK
dc.identifier.hkuros127728-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249781993&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume48en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1173en_HK
dc.identifier.epage1178en_HK
dc.identifier.isiWOS:000247124700021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCowling, BJ=8644765500en_HK
dc.identifier.scopusauthoridShaw, JEH=7102179242en_HK
dc.identifier.scopusauthoridHutton, JL=7202016050en_HK
dc.identifier.scopusauthoridMarson, AG=7006387194en_HK
dc.identifier.citeulike1365773-

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