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Article: Accumulation of p53 protein in inverted transitional cell papilloma of the urinary bladder

TitleAccumulation of p53 protein in inverted transitional cell papilloma of the urinary bladder
Authors
KeywordsImmunohistochemistry
Inverted papilloma
p53
Urothelial neoplasm
Issue Date1996
PublisherB M J Publishing Group. The Journal's web site is located at http://mp.bmjjournals.com/
Citation
Journal Of Clinical Pathology - Clinical Molecular Pathology, 1996, v. 49 n. 1, p. M43-M45 How to Cite?
AbstractAims: To study the possible accumulation of p53 protein in inverted papilloma of the urinary bladder. Methods: Formalin fixed, paraffin wax embedded sections from 14 cases of inverted papilloma of the urinary bladder were studied retrospectively. Accumulation of p53 was detected by immunohistochemistry using a mouse monoclonal antibody directed against p53. p53 protein reactivity was scored as follows: 0 = 10%; 1 = 10% to < 30%; 2 = 30% to < 50%; and 3 = > 50% of cells p53 positive. Results: The 14 sections were scored as follows: 3 in four cases; 2 in four cases; 1 in one case; and 0 in five cases. Overall, nine (64%) of the 14 cases were positive for p53 protein. Conclusions: The accumulation of p53 protein in inverted papilloma of the urinary bladder suggests that p53 may have has an important role in the neoplastic process of this tumour. However, the benign nature of inverted papillomas suggests that p53 protein accumulation is not related to tumour invasiveness and metastasis. p53 reactivity cannot be used as a marker of malignancy for urothelial neoplasia. Further studies are required to determine the role of p53 protein in the oncogenesis of urothelial neoplasms.
Persistent Identifierhttp://hdl.handle.net/10722/54185
ISSN
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KWen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.date.accessioned2009-04-03T07:39:01Z-
dc.date.available2009-04-03T07:39:01Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Clinical Pathology - Clinical Molecular Pathology, 1996, v. 49 n. 1, p. M43-M45en_HK
dc.identifier.issn1355-2910en_HK
dc.identifier.urihttp://hdl.handle.net/10722/54185-
dc.description.abstractAims: To study the possible accumulation of p53 protein in inverted papilloma of the urinary bladder. Methods: Formalin fixed, paraffin wax embedded sections from 14 cases of inverted papilloma of the urinary bladder were studied retrospectively. Accumulation of p53 was detected by immunohistochemistry using a mouse monoclonal antibody directed against p53. p53 protein reactivity was scored as follows: 0 = 10%; 1 = 10% to < 30%; 2 = 30% to < 50%; and 3 = > 50% of cells p53 positive. Results: The 14 sections were scored as follows: 3 in four cases; 2 in four cases; 1 in one case; and 0 in five cases. Overall, nine (64%) of the 14 cases were positive for p53 protein. Conclusions: The accumulation of p53 protein in inverted papilloma of the urinary bladder suggests that p53 may have has an important role in the neoplastic process of this tumour. However, the benign nature of inverted papillomas suggests that p53 protein accumulation is not related to tumour invasiveness and metastasis. p53 reactivity cannot be used as a marker of malignancy for urothelial neoplasia. Further studies are required to determine the role of p53 protein in the oncogenesis of urothelial neoplasms.en_HK
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://mp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathology - Clinical Molecular Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.subjectImmunohistochemistryen_HK
dc.subjectInverted papillomaen_HK
dc.subjectp53en_HK
dc.subjectUrothelial neoplasmen_HK
dc.titleAccumulation of p53 protein in inverted transitional cell papilloma of the urinary bladderen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=49&issue=1&spage=M43&epage=M45&date=1996&atitle=Accumulation+of+p53+protein+in+inverted+transitional+cell+papilloma+of+the+urinary+bladderen_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid16696044en_HK
dc.identifier.pmcidPMC408017-
dc.identifier.scopuseid_2-s2.0-0030050325en_HK
dc.identifier.hkuros26077-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030050325&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue1en_HK
dc.identifier.spageM43en_HK
dc.identifier.epageM45en_HK
dc.publisher.placeUnited Kingdomen_HK

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