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Article: Antimyeloperoxidase antibody in Chinese patients in Hong Kong: a five-year review

TitleAntimyeloperoxidase antibody in Chinese patients in Hong Kong: a five-year review
Authors
KeywordsAutoantibodies
Vasulitis
Myeloperoxidase
Issue Date1996
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org
Citation
Hong Kong Medical Journal, 1996, v. 2 n. 1, p. 40-46 How to Cite?
AbstractAn analysis was made of 51 Chinese patients who tested positive for antimyeloperoxidase antibody (anti-MPO) in the five-year period from 1989 to 1993 in Hong Kong. Nineteen could be clearly classified as having an identifiable vasculitic illness, while the features of the remainder were suggestive of vasculitic syndromes in most cases. Renal disease was present in 84% of all cases and was the commonest manifestation, followed by pulmonary diseases. Acute or acute-on-chronic renal failure developed in 20 patients (39%). Of those who had renal biopsy performed, over half had histologic evidence of crescentic glomerulonephritis. Anti-MPO associated disease carried a grave prognosis with significant morbidity and mortality. Steroid and immunosuppressive therapy was given to most of the patients and in those who responded to immunosuppressive therapy, anti-MPO was a useful marker for monitoring disease activity. Twenty patients died, either of complications or as a result of disease activity.
Persistent Identifierhttp://hdl.handle.net/10722/54172
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLee, SSen_HK
dc.contributor.authorLawton, JWMen_HK
dc.date.accessioned2009-04-03T07:38:40Z-
dc.date.available2009-04-03T07:38:40Z-
dc.date.issued1996en_HK
dc.identifier.citationHong Kong Medical Journal, 1996, v. 2 n. 1, p. 40-46en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/54172-
dc.description.abstractAn analysis was made of 51 Chinese patients who tested positive for antimyeloperoxidase antibody (anti-MPO) in the five-year period from 1989 to 1993 in Hong Kong. Nineteen could be clearly classified as having an identifiable vasculitic illness, while the features of the remainder were suggestive of vasculitic syndromes in most cases. Renal disease was present in 84% of all cases and was the commonest manifestation, followed by pulmonary diseases. Acute or acute-on-chronic renal failure developed in 20 patients (39%). Of those who had renal biopsy performed, over half had histologic evidence of crescentic glomerulonephritis. Anti-MPO associated disease carried a grave prognosis with significant morbidity and mortality. Steroid and immunosuppressive therapy was given to most of the patients and in those who responded to immunosuppressive therapy, anti-MPO was a useful marker for monitoring disease activity. Twenty patients died, either of complications or as a result of disease activity.en_HK
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.orgen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.en_HK
dc.subjectAutoantibodiesen_HK
dc.subjectVasulitisen_HK
dc.subjectMyeloperoxidaseen_HK
dc.titleAntimyeloperoxidase antibody in Chinese patients in Hong Kong: a five-year reviewen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=2&issue=1&spage=40&epage=46&date=1996&atitle=Antimyeloperoxidase+antibody+in+Chinese+patients+in+Hong+Kong:+a+five-year+reviewen_HK
dc.identifier.emailLawton, JWM: jwml@hkucc.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.hkuros14043-

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