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Conference Paper: Visual function due to regeneration of optic nerve or optic tract through peripheral nerve homografts

TitleVisual function due to regeneration of optic nerve or optic tract through peripheral nerve homografts
Authors
KeywordsRegeneration
Retinotectal
Sciatic
Graft
Issue Date2000
PublisherSociety for Neuroscience. The Journal's web site is located at http://sfn.scholarone.com/
Citation
Neuroscience 2000, New Orleans, LA, 4-9 November 2000, Presentation no. 229.8 How to Cite?
AbstractSegments of sciatic nerve from one leg were used to induce regeneration of transected optic nerve (ON) or tract in Syrian hamsters. In the first group, the nerve graft was sutured to the stump of the transected ON of the right eye in young adult animals, and the other end was placed below the surface of the ipsilateral superior colliculus (SC); the opposite eye was removed. In one animal, orienting movements in the wrong direction were elicited and recorded on videotape, beginning when the animal was more than 1.5 yr old, over 1 yr after surgery. In the second group, a similar procedure was used but with the nerve going to the contralateral SC. In 3 of 4 long-term survivors, visually elicited turning was obtained and recorded, most reliably in the final 4 mo of their 2-yr life. Regenerating retinofugal axons were traced and their terminations in SC reconstructed using a CT-B procedure and immunohistochemistry (secondary AB conjugated to Alexa-488) and fluorescence microscopy. The visually unresponsive animal had no regeneration, and the most responsive animal had the greatest amount of regeneration. In a 3rd procedure, the right brachium of SC was transected, and 2 or 3 segments of sciatic nerve were implanted as bridges to elicit optic tract regeneration. The first 3 of these animals were operated at age 13-19 days; considerable regeneration was verified anatomically in each case, after behavioral demonstration of visual orienting. Supported by NIH grant EY00126.
Persistent Identifierhttp://hdl.handle.net/10722/53986

 

DC FieldValueLanguage
dc.contributor.authorSchneider, GEen_HK
dc.contributor.authorYou, SWen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorCarter, DAen_HK
dc.contributor.authorKhan, Fen_HK
dc.contributor.authorEllis-Behnke, Ren_HK
dc.contributor.authorOkobi, Aen_HK
dc.date.accessioned2009-04-03T07:33:35Z-
dc.date.available2009-04-03T07:33:35Z-
dc.date.issued2000en_HK
dc.identifier.citationNeuroscience 2000, New Orleans, LA, 4-9 November 2000, Presentation no. 229.8en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53986-
dc.description.abstractSegments of sciatic nerve from one leg were used to induce regeneration of transected optic nerve (ON) or tract in Syrian hamsters. In the first group, the nerve graft was sutured to the stump of the transected ON of the right eye in young adult animals, and the other end was placed below the surface of the ipsilateral superior colliculus (SC); the opposite eye was removed. In one animal, orienting movements in the wrong direction were elicited and recorded on videotape, beginning when the animal was more than 1.5 yr old, over 1 yr after surgery. In the second group, a similar procedure was used but with the nerve going to the contralateral SC. In 3 of 4 long-term survivors, visually elicited turning was obtained and recorded, most reliably in the final 4 mo of their 2-yr life. Regenerating retinofugal axons were traced and their terminations in SC reconstructed using a CT-B procedure and immunohistochemistry (secondary AB conjugated to Alexa-488) and fluorescence microscopy. The visually unresponsive animal had no regeneration, and the most responsive animal had the greatest amount of regeneration. In a 3rd procedure, the right brachium of SC was transected, and 2 or 3 segments of sciatic nerve were implanted as bridges to elicit optic tract regeneration. The first 3 of these animals were operated at age 13-19 days; considerable regeneration was verified anatomically in each case, after behavioral demonstration of visual orienting. Supported by NIH grant EY00126.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience. The Journal's web site is located at http://sfn.scholarone.com/en_HK
dc.relation.ispartofSociety for Neuroscience Annual Meeting-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsSociety for Neuroscience Abstract viewer & itinerary planner. Copyright © Society for Neuroscience.en_HK
dc.subjectRegeneration-
dc.subjectRetinotectal-
dc.subjectSciatic-
dc.subjectGraft-
dc.titleVisual function due to regeneration of optic nerve or optic tract through peripheral nerve homograftsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.hkuros56129-

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