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Article: The effect of ageing on female fertility in an assisted reproduction programme in Hong Kong: retrospective study.

TitleThe effect of ageing on female fertility in an assisted reproduction programme in Hong Kong: retrospective study.
Authors
Issue Date2000
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2000, v. 6 n. 2, p. 147-152 How to Cite?
AbstractOBJECTIVE: To analyse the effect of ageing on female fertility in an in vitro fertilisation programme in Hong Kong. DESIGN: Retrospective study. SETTING: University teaching hospital, Hong Kong. PATIENTS: Seven hundred and seventy-one women in whom 1336 cycles of in vitro fertilisation were initiated between 1 January 1986 and 31 December 1995. MAIN OUTCOME MEASURES: Patient age and indications for treatment; hormonal response; and the number of cancelled cycles, oocytes retrieved, oocytes fertilised, cleaving embryos, embryos transferred, and clinical pregnancies. RESULTS: Compared with women aged or =36 years (n=398) had a significantly higher cycle cancellation rate (19.3% versus 10.4%), fewer oocytes retrieved per retrieval cycle (6.6 versus 9.0), fewer oocytes fertilised per retrieval cycle (5.0 versus 7.0), fewer cleaving embryos per retrieval cycle (4.8 versus 6.8), and lower serum oestradiol level (9735 [standard deviation, 5681] pmol/L versus 10 708 [5916] pmol/L) despite a larger amount of human menopausal gonadotrophin having been used (all variables, P<0.01; Chi squared test). The clinical pregnancy rate per initiated cycle (range, 7.5%-13.0%) decreased with advancing age (P<0.01; Chi squared test). CONCLUSION: Ageing has a significant deleterious effect on women's reproductive capability. Women should be encouraged to seek early medical advice and treatment for subfertility.
Persistent Identifierhttp://hdl.handle.net/10722/53572
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLau, WNen_HK
dc.contributor.authorSo, WWen_HK
dc.contributor.authorYeung, WSen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2009-04-03T07:23:30Z-
dc.date.available2009-04-03T07:23:30Z-
dc.date.issued2000en_HK
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2000, v. 6 n. 2, p. 147-152en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53572-
dc.description.abstractOBJECTIVE: To analyse the effect of ageing on female fertility in an in vitro fertilisation programme in Hong Kong. DESIGN: Retrospective study. SETTING: University teaching hospital, Hong Kong. PATIENTS: Seven hundred and seventy-one women in whom 1336 cycles of in vitro fertilisation were initiated between 1 January 1986 and 31 December 1995. MAIN OUTCOME MEASURES: Patient age and indications for treatment; hormonal response; and the number of cancelled cycles, oocytes retrieved, oocytes fertilised, cleaving embryos, embryos transferred, and clinical pregnancies. RESULTS: Compared with women aged <or =30 years (n=193), women aged > or =36 years (n=398) had a significantly higher cycle cancellation rate (19.3% versus 10.4%), fewer oocytes retrieved per retrieval cycle (6.6 versus 9.0), fewer oocytes fertilised per retrieval cycle (5.0 versus 7.0), fewer cleaving embryos per retrieval cycle (4.8 versus 6.8), and lower serum oestradiol level (9735 [standard deviation, 5681] pmol/L versus 10 708 [5916] pmol/L) despite a larger amount of human menopausal gonadotrophin having been used (all variables, P<0.01; Chi squared test). The clinical pregnancy rate per initiated cycle (range, 7.5%-13.0%) decreased with advancing age (P<0.01; Chi squared test). CONCLUSION: Ageing has a significant deleterious effect on women's reproductive capability. Women should be encouraged to seek early medical advice and treatment for subfertility.en_HK
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicineen_HK
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAgingen_HK
dc.subject.meshFertilityen_HK
dc.subject.meshFertilization in Vitroen_HK
dc.subject.meshFollicle Stimulating Hormone - blooden_HK
dc.subject.meshRetrospective Studiesen_HK
dc.titleThe effect of ageing on female fertility in an assisted reproduction programme in Hong Kong: retrospective study.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=6&issue=2&spage=147&epage=152&date=2000&atitle=The+effect+of+ageing+on+female+fertility+in+an+assisted+reproduction+programme+in+Hong+Kong:+retrospective+studyen_HK
dc.identifier.emailYeung, WS:wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityYeung, WS=rp00331en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid10895136-
dc.identifier.scopuseid_2-s2.0-0034202953en_HK
dc.identifier.hkuros50084-
dc.identifier.volume6en_HK
dc.identifier.issue2en_HK
dc.identifier.spage147en_HK
dc.identifier.epage152en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridLau, WN=36847553600en_HK
dc.identifier.scopusauthoridSo, WW=7004974015en_HK
dc.identifier.scopusauthoridYeung, WS=7102370745en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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