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Article: Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups

TitleSeroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups
Authors
Issue Date2006
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG
Citation
Epidemiology And Infection, 2006, v. 134 n. 2, p. 211-221 How to Cite?
AbstractWe systematically reviewed the current understanding of human population immunity against SARS-CoV in different groups, settings and geography. Our meta-analysis, which included all identified studies except those on wild animal handlers, yielded an overall seroprevalence of 0.10% [95% confidence interval (CI) 0.02-0.18]. Health-care workers and others who had close contact with SARS patients had a slightly higher degree of seroconversion (0.23%, 95% CI 0.02-0.45) compared to healthy blood donors, others from the general community or non-SARS patients recruited from the health-care setting (0.16%, 95% CI 0-0.37). When analysed by the two broad classes of testing procedures, it is clear that serial confirmatory test protocols resulted in a much lower estimate (0.050%, 95% CI 0-0.15) than single test protocols (0.20%, 95% CI 0.06-0.34). Potential epidemiological and laboratory pitfalls are also discussed as they may give rise to false or inconsistent results in measuring the seroprevalence of IgG antibodies to SARS-CoV. © 2005 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/53555
ISSN
2015 Impact Factor: 2.515
2015 SCImago Journal Rankings: 1.320
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorLim, WWen_HK
dc.contributor.authorHo, LMen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorGhani, ACen_HK
dc.contributor.authorDonnelly, CAen_HK
dc.contributor.authorFraser, Cen_HK
dc.contributor.authorRiley, Sen_HK
dc.contributor.authorFerguson, NMen_HK
dc.contributor.authorAnderson, RMen_HK
dc.contributor.authorHedley, AJen_HK
dc.date.accessioned2009-04-03T07:23:03Z-
dc.date.available2009-04-03T07:23:03Z-
dc.date.issued2006en_HK
dc.identifier.citationEpidemiology And Infection, 2006, v. 134 n. 2, p. 211-221en_HK
dc.identifier.issn0950-2688en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53555-
dc.description.abstractWe systematically reviewed the current understanding of human population immunity against SARS-CoV in different groups, settings and geography. Our meta-analysis, which included all identified studies except those on wild animal handlers, yielded an overall seroprevalence of 0.10% [95% confidence interval (CI) 0.02-0.18]. Health-care workers and others who had close contact with SARS patients had a slightly higher degree of seroconversion (0.23%, 95% CI 0.02-0.45) compared to healthy blood donors, others from the general community or non-SARS patients recruited from the health-care setting (0.16%, 95% CI 0-0.37). When analysed by the two broad classes of testing procedures, it is clear that serial confirmatory test protocols resulted in a much lower estimate (0.050%, 95% CI 0-0.15) than single test protocols (0.20%, 95% CI 0.06-0.34). Potential epidemiological and laboratory pitfalls are also discussed as they may give rise to false or inconsistent results in measuring the seroprevalence of IgG antibodies to SARS-CoV. © 2005 Cambridge University Press.en_HK
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dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYGen_HK
dc.relation.ispartofEpidemiology and Infectionen_HK
dc.rightsEpidemiology and Infection. Copyright © Cambridge University Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshImmunoglobulin-G-analysisen_HK
dc.subject.meshSARS-Virus-immunologyen_HK
dc.subject.meshSARS-Virus-pathogenicityen_HK
dc.subject.meshSevere-Acute-Respiratory-Syndrome-immunologyen_HK
dc.subject.meshSeroepidemiologic Studiesen_HK
dc.subject.meshAntibody Formationen_HK
dc.titleSeroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groupsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-2688&volume=134&issue=2&spage=211&epage=221&date=2006&atitle=Seroprevalence+of+IgG+antibodies+to+SARS-coronavirus+in+asymptomatic+or+subclinical+population+groups.en_HK
dc.identifier.emailLeung, GM:gmleung@hku.hken_HK
dc.identifier.emailHo, LM:lmho@hkucc.hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailRiley, S:sriley@hkucc.hku.hk, steven.riley@hku.hken_HK
dc.identifier.emailHedley, AJ:hrmrajh@hkucc.hku.hken_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authorityHo, LM=rp00360en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityRiley, S=rp00511en_HK
dc.identifier.authorityHedley, AJ=rp00357en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1017/S0950268805004826en_HK
dc.identifier.pmid16490123-
dc.identifier.pmcidPMC2870380-
dc.identifier.scopuseid_2-s2.0-33244460572en_HK
dc.identifier.hkuros115449-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33244460572&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume134en_HK
dc.identifier.issue2en_HK
dc.identifier.spage211en_HK
dc.identifier.epage221en_HK
dc.identifier.isiWOS:000236138600001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridLim, WW=7202378267en_HK
dc.identifier.scopusauthoridHo, LM=7402955625en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridGhani, AC=7006814439en_HK
dc.identifier.scopusauthoridDonnelly, CA=35468127900en_HK
dc.identifier.scopusauthoridFraser, C=35460815100en_HK
dc.identifier.scopusauthoridRiley, S=7102619416en_HK
dc.identifier.scopusauthoridFerguson, NM=7103246319en_HK
dc.identifier.scopusauthoridAnderson, RM=7408244444en_HK
dc.identifier.scopusauthoridHedley, AJ=7102584095en_HK
dc.identifier.citeulike6866302-

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