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Article: Signal transduction mechanisms mediating secretion in goldfish gonadotropes and somatotropes

TitleSignal transduction mechanisms mediating secretion in goldfish gonadotropes and somatotropes
Authors
KeywordsCa2+ signaling
cAMP
PKC
Arachidonic acid
NO
Issue Date2000
PublisherNRC Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?bcb
Citation
Biochemistry and Cell Biology, 2000, v. 78 n. 3, p. 139-153 How to Cite?
AbstractThe intracellular signal transduction mechanisms mediating maturational gonadotropin and somatotropin secretion in goldfish are reviewed. Several major signaling mechanisms, including changes in intracellular [Ca2+], arachidonic acid cascades, protein kinase C, cyclic AMP/protein kinase A, calmodulin, nitric oxide, and Na+/H+ antiport, are functional in both cell types. However, their relative importance in mediating basal secretion and neuroendocrine-factor-regulated hormone release differs according to cell type. Similarly, agonist- and cell-type-specificity are also present in the transduction pathways leading to neuroendocrine factor-modulated maturational gonadotropin and somatotropin release. Specificity is present not only in the actions of different regulators within the same cell type and with the same ligand in the two cell types, but this also exists between isoforms of the same neuroendocrine factor within a single cell type. Other evidence suggests that function-selectivity of signaling may also result from differential modulation of Ca2+ fluxes from different sources. The interaction of different second messenger systems provide the basis by which regulation of maturational gonadotropin and somatotropin release by multiple neuroendocrine factors can be integrated at the target cell level.
Persistent Identifierhttp://hdl.handle.net/10722/53491
ISSN
2015 Impact Factor: 1.527
2015 SCImago Journal Rankings: 0.859
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChang, JP-
dc.contributor.authorJohnson, JD-
dc.contributor.authorVan Goor, F-
dc.contributor.authorWong, CJH-
dc.contributor.authorYunker, WK-
dc.contributor.authorUretsky, AD-
dc.contributor.authorTaylor, D-
dc.contributor.authorJobin, RM-
dc.contributor.authorWong, AOL-
dc.contributor.authorGoldberg, JI-
dc.date.accessioned2009-04-03T07:21:21Z-
dc.date.available2009-04-03T07:21:21Z-
dc.date.issued2000-
dc.identifier.citationBiochemistry and Cell Biology, 2000, v. 78 n. 3, p. 139-153-
dc.identifier.issn0829-8211-
dc.identifier.urihttp://hdl.handle.net/10722/53491-
dc.description.abstractThe intracellular signal transduction mechanisms mediating maturational gonadotropin and somatotropin secretion in goldfish are reviewed. Several major signaling mechanisms, including changes in intracellular [Ca2+], arachidonic acid cascades, protein kinase C, cyclic AMP/protein kinase A, calmodulin, nitric oxide, and Na+/H+ antiport, are functional in both cell types. However, their relative importance in mediating basal secretion and neuroendocrine-factor-regulated hormone release differs according to cell type. Similarly, agonist- and cell-type-specificity are also present in the transduction pathways leading to neuroendocrine factor-modulated maturational gonadotropin and somatotropin release. Specificity is present not only in the actions of different regulators within the same cell type and with the same ligand in the two cell types, but this also exists between isoforms of the same neuroendocrine factor within a single cell type. Other evidence suggests that function-selectivity of signaling may also result from differential modulation of Ca2+ fluxes from different sources. The interaction of different second messenger systems provide the basis by which regulation of maturational gonadotropin and somatotropin release by multiple neuroendocrine factors can be integrated at the target cell level.-
dc.languageeng-
dc.publisherNRC Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?bcb-
dc.relation.ispartofBiochemistry and Cell Biology-
dc.rightsBiochemistry and Cell Biology. Copyright © N R C Research Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCa2+ signaling-
dc.subjectcAMP-
dc.subjectPKC-
dc.subjectArachidonic acid-
dc.subjectNO-
dc.subject.meshGoldfish - metabolism - physiologyen_HK
dc.subject.meshGonadotropins - metabolismen_HK
dc.subject.meshGrowth Hormone - metabolismen_HK
dc.subject.meshSignal Transductionen_HK
dc.subject.meshProtein Kinase C - metabolismen_HK
dc.titleSignal transduction mechanisms mediating secretion in goldfish gonadotropes and somatotropes-
dc.typeArticle-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0829-8211&volume=78&issue=3&spage=139&epage=153&date=2000&atitle=Signal+transduction+mechanisms+mediating+secretion+in+goldfish+gonadotropes+and+somatotropesen_HK
dc.identifier.emailWong, AOL: olwong@hkucc.hku.hk-
dc.identifier.authorityWong, AOL=rp00806-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1139/o00-011-
dc.identifier.pmid10949070-
dc.identifier.scopuseid_2-s2.0-0033864723en_HK
dc.identifier.hkuros53068-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033864723&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78-
dc.identifier.issue3-
dc.identifier.spage139-
dc.identifier.epage153-
dc.identifier.isiWOS:000088408600002-
dc.publisher.placeCanada-
dc.identifier.scopusauthoridChang, JP=7601547649en_HK
dc.identifier.scopusauthoridJohnson, JD=14121618900en_HK
dc.identifier.scopusauthoridVan Goor, F=35845505200en_HK
dc.identifier.scopusauthoridWong, CJH=9939547700en_HK
dc.identifier.scopusauthoridYunker, WK=24449778300en_HK
dc.identifier.scopusauthoridUretsky, AD=6506115333en_HK
dc.identifier.scopusauthoridTaylor, D=7406864889en_HK
dc.identifier.scopusauthoridJobin, RM=6701719589en_HK
dc.identifier.scopusauthoridWong, AOL=7403147570en_HK
dc.identifier.scopusauthoridGoldberg, JI=7403090439en_HK

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