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Article: Secretin facilitates GABA transmission in the cerebellum

TitleSecretin facilitates GABA transmission in the cerebellum
Authors
KeywordsAutism
Cerebellum
GABA
Inhibitory postsynaptic currents
Purkinje cells
Secretin
Issue Date2001
PublisherSociety for Neuroscience. The Journal's web site is located at http://www.jneurosci.org
Citation
Journal Of Neuroscience, 2001, v. 21 n. 18, p. 7063-7068 How to Cite?
AbstractSecretin was the first hormone discovered in human history, and yet, its function as a neuropeptide has been overlooked in the past. The recent discovery of the potential use of secretin in treating autistic patients, together with the conflicting reports on its effectiveness, urges an in-depth investigation of this issue. We show here that in the rat cerebellar cortex, mRNAs encoding secretin are localized in the Purkinje cells, whereas those of its receptor are found in both Purkinje cells and GABAergic interneurons. Immunoreactivity for secretin is localized in the soma and dendrites of Purkinje cells. In addition, secretin facilitates evoked, spontaneous, and miniature IPSCs recorded from Purkinje cells. We propose that secretin is released from the somatodendritic region of Purkinje cells and serves as a retrograde messenger modulating GABAergic afferent activity.
Persistent Identifierhttp://hdl.handle.net/10722/53487
ISSN
2015 Impact Factor: 5.924
2015 SCImago Journal Rankings: 5.105
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYung, WHen_HK
dc.contributor.authorLeung, PSen_HK
dc.contributor.authorNg, SSMen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorChan, SCYen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2009-04-03T07:21:14Z-
dc.date.available2009-04-03T07:21:14Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Neuroscience, 2001, v. 21 n. 18, p. 7063-7068en_HK
dc.identifier.issn0270-6474en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53487-
dc.description.abstractSecretin was the first hormone discovered in human history, and yet, its function as a neuropeptide has been overlooked in the past. The recent discovery of the potential use of secretin in treating autistic patients, together with the conflicting reports on its effectiveness, urges an in-depth investigation of this issue. We show here that in the rat cerebellar cortex, mRNAs encoding secretin are localized in the Purkinje cells, whereas those of its receptor are found in both Purkinje cells and GABAergic interneurons. Immunoreactivity for secretin is localized in the soma and dendrites of Purkinje cells. In addition, secretin facilitates evoked, spontaneous, and miniature IPSCs recorded from Purkinje cells. We propose that secretin is released from the somatodendritic region of Purkinje cells and serves as a retrograde messenger modulating GABAergic afferent activity.en_HK
dc.languageengen_HK
dc.publisherSociety for Neuroscience. The Journal's web site is located at http://www.jneurosci.orgen_HK
dc.relation.ispartofJournal of Neuroscienceen_HK
dc.rightsJournal of Neuroscience. Copyright © Society for Neuroscience.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAutismen_HK
dc.subjectCerebellumen_HK
dc.subjectGABAen_HK
dc.subjectInhibitory postsynaptic currentsen_HK
dc.subjectPurkinje cellsen_HK
dc.subjectSecretinen_HK
dc.titleSecretin facilitates GABA transmission in the cerebellumen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-6474&volume=21&issue=8&spage=7063&epage=7068&date=2001&atitle=Secretin+facilitates+GABA+transmission+in+the+cerebellumen_HK
dc.identifier.emailNg, SSM: ssmng@hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityNg, SSM=rp00767en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid11549716-
dc.identifier.scopuseid_2-s2.0-0035884769en_HK
dc.identifier.hkuros65786-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035884769&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue18en_HK
dc.identifier.spage7063en_HK
dc.identifier.epage7068en_HK
dc.identifier.isiWOS:000170922800010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYung, WH=7103137893en_HK
dc.identifier.scopusauthoridLeung, PS=7401748938en_HK
dc.identifier.scopusauthoridNg, SSM=7403358718en_HK
dc.identifier.scopusauthoridZhang, J=7601342104en_HK
dc.identifier.scopusauthoridChan, SCY=25930246600en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

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