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Article: Corticofugal Gating of Auditory Information in the Thalamus: An In Vivo Intracellular Recording Study

TitleCorticofugal Gating of Auditory Information in the Thalamus: An In Vivo Intracellular Recording Study
Authors
KeywordsCorticofugal modulation
Electrical stimulation
EPSP
Excitatory postsynaptic potential
In vivo intracellular recording
Inhibitory postsynaptic potential
IPSP
Low-threshold calcium spike
The medial geniculate body
Issue Date2004
PublisherSociety for Neuroscience. The Journal's web site is located at http://www.jneurosci.org
Citation
Journal Of Neuroscience, 2004, v. 24 n. 12, p. 3060-3069 How to Cite?
AbstractIn the present study, we investigated the auditory responses of the medial geniculate (MGB) neurons, through in vivo intracellular recordings of anesthetized guinea pigs, while the auditory cortex was electrically activated. Of the 63 neurons that received corticofugal modulation of the membrane potential, 30 received potentiation and 33 received hyperpolarization. The corticofugal potentiation of the membrane potential (amplitude, mean ± SD, 8.6 ± 5.5 mV; duration, 125.5 ± 75.4 msec) facilitated the auditory responses and spontaneous firing of the MGB neurons. The hyperpolarization of -11.3 ± 4.9 mV in amplitude and 210.0 ± 210. 1 msec in duration suppressed the auditory responses and spontaneous firing of the MGB neurons. Four of the five neurons that were histologically confirmed to be located in the lemniscal MGB received corticofugal facilitatory modulation, and all of the four neurons that were confirmed to be located in the non-lemniscal MGB received corticofugal inhibitory modulation. The present intracellular recording provides novel results on how the corticofugal projection gates the sensory information in the thalamus: via the spatially selective depolarization of lemniscal MGB neurons and hyperpolarization of non-lemniscal MGB neurons. It is speculated that the systematic selectivity of facilitation and inhibition over the lemniscal and non-lemniscal MGB is related to the attention shift within the auditory modality and across the sensory modalities.
Persistent Identifierhttp://hdl.handle.net/10722/53465
ISSN
2015 Impact Factor: 5.924
2015 SCImago Journal Rankings: 5.105
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, YQen_HK
dc.contributor.authorXiong, Yen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorHe, Jen_HK
dc.date.accessioned2009-04-03T07:20:32Z-
dc.date.available2009-04-03T07:20:32Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Neuroscience, 2004, v. 24 n. 12, p. 3060-3069en_HK
dc.identifier.issn0270-6474en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53465-
dc.description.abstractIn the present study, we investigated the auditory responses of the medial geniculate (MGB) neurons, through in vivo intracellular recordings of anesthetized guinea pigs, while the auditory cortex was electrically activated. Of the 63 neurons that received corticofugal modulation of the membrane potential, 30 received potentiation and 33 received hyperpolarization. The corticofugal potentiation of the membrane potential (amplitude, mean ± SD, 8.6 ± 5.5 mV; duration, 125.5 ± 75.4 msec) facilitated the auditory responses and spontaneous firing of the MGB neurons. The hyperpolarization of -11.3 ± 4.9 mV in amplitude and 210.0 ± 210. 1 msec in duration suppressed the auditory responses and spontaneous firing of the MGB neurons. Four of the five neurons that were histologically confirmed to be located in the lemniscal MGB received corticofugal facilitatory modulation, and all of the four neurons that were confirmed to be located in the non-lemniscal MGB received corticofugal inhibitory modulation. The present intracellular recording provides novel results on how the corticofugal projection gates the sensory information in the thalamus: via the spatially selective depolarization of lemniscal MGB neurons and hyperpolarization of non-lemniscal MGB neurons. It is speculated that the systematic selectivity of facilitation and inhibition over the lemniscal and non-lemniscal MGB is related to the attention shift within the auditory modality and across the sensory modalities.en_HK
dc.languageengen_HK
dc.publisherSociety for Neuroscience. The Journal's web site is located at http://www.jneurosci.orgen_HK
dc.relation.ispartofJournal of Neuroscienceen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Neuroscience. Copyright © Society for Neuroscience.en_HK
dc.subjectCorticofugal modulationen_HK
dc.subjectElectrical stimulationen_HK
dc.subjectEPSPen_HK
dc.subjectExcitatory postsynaptic potentialen_HK
dc.subjectIn vivo intracellular recordingen_HK
dc.subjectInhibitory postsynaptic potentialen_HK
dc.subjectIPSPen_HK
dc.subjectLow-threshold calcium spikeen_HK
dc.subjectThe medial geniculate bodyen_HK
dc.titleCorticofugal Gating of Auditory Information in the Thalamus: An In Vivo Intracellular Recording Studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-6474&volume=24&issue=12&spage=3060&epage=3069&date=2004&atitle=Corticofugal+gating+of+auditory+information+in+the+thalamus:+an+in+vivo+intracellular+recording+studyen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1523/JNEUROSCI.4897-03.2004en_HK
dc.identifier.pmid15044545en_HK
dc.identifier.scopuseid_2-s2.0-1642546600en_HK
dc.identifier.hkuros92153-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642546600&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue12en_HK
dc.identifier.spage3060en_HK
dc.identifier.epage3069en_HK
dc.identifier.isiWOS:000220500900022-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYu, YQ=7406253532en_HK
dc.identifier.scopusauthoridXiong, Y=8706548900en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridHe, J=7404984971en_HK

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