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Article: Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population

TitleAssociations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population
Authors
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2004, v. 190 n. 5, p. 913-919 How to Cite?
AbstractBackground. Interleukin (IL)-12 plays a vital role in regulating cell-mediated immunity against tuberculosis (TB). Methods. To test whether IL12B genetic polymorphisms might contribute to human TB susceptibility, we examined the genotype frequencies of 5 IL12B polymorphisms (at promoter, intron 2, intron 4, exon 5, and 3′ untranslated region [UTR]) in 516 patients with TB and 514 healthy control subjects from the Hong Kong Chinese population. Results. Individuals homozygous for the IL12B intron 2-repeat marker (ATT) 8 had a 2.1-fold increased risk of developing TB (P < .001) (odds ratio, 2.14 [95% confidence interval, 1.45-3.19]). Estimation of the frequencies of multiple-locus haplotypes composed of IL12B promoter, intron 2, intron 4, and 3′ UTR alleles revealed potential risk haplotypes (designated "A" and "K") and protective haplotypes (designated "B") for TB. Furthermore, combining the genotype data of the 4 informative IL12B loci revealed a strong association between a specific genotype pattern, termed "diplotype I" (heterozygous A and K haplotypes), and TB. In contrast, diplotype II (homozygous BB haplotypes) appeared protective against TB. Conclusions. These findings support the association between IL12B intron 2 polymorphism and TB and between specific IL12B haplotypes and TB.
Persistent Identifierhttp://hdl.handle.net/10722/53448
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTso, HWen_HK
dc.contributor.authorYu, LLen_HK
dc.contributor.authorTam, CMen_HK
dc.contributor.authorWong, HSen_HK
dc.contributor.authorChiang, AKSen_HK
dc.date.accessioned2009-04-03T07:20:03Z-
dc.date.available2009-04-03T07:20:03Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2004, v. 190 n. 5, p. 913-919en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53448-
dc.description.abstractBackground. Interleukin (IL)-12 plays a vital role in regulating cell-mediated immunity against tuberculosis (TB). Methods. To test whether IL12B genetic polymorphisms might contribute to human TB susceptibility, we examined the genotype frequencies of 5 IL12B polymorphisms (at promoter, intron 2, intron 4, exon 5, and 3′ untranslated region [UTR]) in 516 patients with TB and 514 healthy control subjects from the Hong Kong Chinese population. Results. Individuals homozygous for the IL12B intron 2-repeat marker (ATT) 8 had a 2.1-fold increased risk of developing TB (P < .001) (odds ratio, 2.14 [95% confidence interval, 1.45-3.19]). Estimation of the frequencies of multiple-locus haplotypes composed of IL12B promoter, intron 2, intron 4, and 3′ UTR alleles revealed potential risk haplotypes (designated "A" and "K") and protective haplotypes (designated "B") for TB. Furthermore, combining the genotype data of the 4 informative IL12B loci revealed a strong association between a specific genotype pattern, termed "diplotype I" (heterozygous A and K haplotypes), and TB. In contrast, diplotype II (homozygous BB haplotypes) appeared protective against TB. Conclusions. These findings support the association between IL12B intron 2 polymorphism and TB and between specific IL12B haplotypes and TB.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org en_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.rightsJournal of Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAsian continental ancestry groupen_HK
dc.subject.meshGenetic predisposition to diseaseen_HK
dc.subject.meshInterleukin-12 - genetics - metabolismen_HK
dc.subject.meshMycobacterium tuberculosisen_HK
dc.subject.meshPolymorphism, geneticen_HK
dc.titleAssociations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=190&issue=5&spage=913&epage=919&date=2004&atitle=Associations+between+IL12B+polymorphisms+and+tuberculosis+in+the+Hong+Kong+Chinese+populationen_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1086/422693en_HK
dc.identifier.pmid15295696-
dc.identifier.scopuseid_2-s2.0-4344717316en_HK
dc.identifier.hkuros96425-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4344717316&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume190en_HK
dc.identifier.issue5en_HK
dc.identifier.spage913en_HK
dc.identifier.epage919en_HK
dc.identifier.isiWOS:000223114800007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTso, HW=7003664344en_HK
dc.identifier.scopusauthoridYu, LL=8617704200en_HK
dc.identifier.scopusauthoridTam, CM=7201442997en_HK
dc.identifier.scopusauthoridWong, HS=20736018600en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK

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