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Article: Childhood acute lymphoblastic leukaemia masquerading as primary skeletal problem

TitleChildhood acute lymphoblastic leukaemia masquerading as primary skeletal problem
Authors
KeywordsAcute lymphobiastic leukaemia
Children
Skeletal complication
Issue Date1994
PublisherHong Kong Medical Association.
Citation
Journal of the Hong Kong Medical Association, 1994, v. 46 n. 3, p. 231-235 How to Cite?
AbstractAcute lymphobiastic leukaemia (ALL) usually presents with signs of bone marrow failure, Occasionally ALL in children may present with non-specific or misleading clinical features. In a retrospect analysis of 25 consecutive cases of childhood ALL, we identified three children who were initially managed and discharged as acute osteomyelitis, juvenile chronic arthritis and postinfectious arthralgia respectively. They had mild normochromic, normocytic anaemia and two had transient leucopenia. Their platelet counts were normal and none had circulating blasts. The severity of their skeletal symptoms was out of proportion to the clinical and radiological finding. They failed to respond to the initial management and diagnosis was delayed for an average of 42 days and eventually confirmed on the marrow aspirate. Complete remission was attained in all cases with standard chemotherapy and had been maintained for an average of 29 months. ALL should be considered as a differential diagnosis in children complaining of multiple or persistent joint pains, especially in the presence of atypical clinical features or poor response to treatment.
Persistent Identifierhttp://hdl.handle.net/10722/53445
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLee, ACWen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorChiu, Wen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2009-04-03T07:19:59Z-
dc.date.available2009-04-03T07:19:59Z-
dc.date.issued1994en_HK
dc.identifier.citationJournal of the Hong Kong Medical Association, 1994, v. 46 n. 3, p. 231-235en_HK
dc.identifier.issn1010-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53445-
dc.description.abstractAcute lymphobiastic leukaemia (ALL) usually presents with signs of bone marrow failure, Occasionally ALL in children may present with non-specific or misleading clinical features. In a retrospect analysis of 25 consecutive cases of childhood ALL, we identified three children who were initially managed and discharged as acute osteomyelitis, juvenile chronic arthritis and postinfectious arthralgia respectively. They had mild normochromic, normocytic anaemia and two had transient leucopenia. Their platelet counts were normal and none had circulating blasts. The severity of their skeletal symptoms was out of proportion to the clinical and radiological finding. They failed to respond to the initial management and diagnosis was delayed for an average of 42 days and eventually confirmed on the marrow aspirate. Complete remission was attained in all cases with standard chemotherapy and had been maintained for an average of 29 months. ALL should be considered as a differential diagnosis in children complaining of multiple or persistent joint pains, especially in the presence of atypical clinical features or poor response to treatment.en_HK
dc.languageengen_HK
dc.publisherHong Kong Medical Association.en_HK
dc.rightsJournal of the Hong Kong Medical Association. Copyright © Hong Kong Medical Association.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAcute lymphobiastic leukaemiaen_HK
dc.subjectChildrenen_HK
dc.subjectSkeletal complicationen_HK
dc.titleChildhood acute lymphoblastic leukaemia masquerading as primary skeletal problemen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1010-8424&volume=46&issue=3&spage=231&epage=235&date=1994&atitle=Childhood+acute+lymphoblastic+leukaemia+masquerading+as+primary+skeletal+problemen_HK
dc.identifier.emailLau, YL: lauylung@hkucc.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.hkuros2509-

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