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Article: Human infection by avian influenza A H5N1

TitleHuman infection by avian influenza A H5N1
Authors
KeywordsHemagglutinins
Humans
Influenza A virus, avian
Influenza A virus, human
Issue Date2005
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal, 2005, v. 11 n. 3, p. 189-199 How to Cite?
AbstractThe Southeast Asian outbreak of the highly lethal avian influenza A HSN1 infection in humans is unlikely to abate because of the enormous number of backyard farms providing poultry as the main source of food protein in developing countries. This increases the risk of the emergence of a reassortant pandemic influenza virus with improved human-to-human transmissibility. Currently triage of suspected cases by epidemiological risk factors remains the only practical way of case identification for laboratory investigation and infection control. The clinical usefulness of rapid diagnostic laboratory tests requires more vigorous evaluation. The lethality of this disease may reflect systemic viral dissemination, cytokine storm, or alveolar flooding due to inhibition of cellular sodium channels. The present circulating genotype Z is intrinsically resistant to amantadine and rimantadine. Prognosis may be improved by early treatment with a neuraminidase inhibitor with good systemic drug levels, and post-exposure prophylaxis for health care workers is recommended. The role of immunomodulators and other modalities of therapy requires evaluation in randomised controlled trials, with prospective monitoring of the viral load and cytokine profiles in various clinical specimens. In view of the high fatality of the disease, a combination of contact, droplet, and airborne precautions are recommended as long as resources allow despite the fact that the relative importance of these three modes in nosocomial transmission of avian influenza is still unknown.
Persistent Identifierhttp://hdl.handle.net/10722/53440
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorWong, SSYen_HK
dc.date.accessioned2009-04-03T07:19:48Z-
dc.date.available2009-04-03T07:19:48Z-
dc.date.issued2005en_HK
dc.identifier.citationHong Kong Medical Journal, 2005, v. 11 n. 3, p. 189-199en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53440-
dc.description.abstractThe Southeast Asian outbreak of the highly lethal avian influenza A HSN1 infection in humans is unlikely to abate because of the enormous number of backyard farms providing poultry as the main source of food protein in developing countries. This increases the risk of the emergence of a reassortant pandemic influenza virus with improved human-to-human transmissibility. Currently triage of suspected cases by epidemiological risk factors remains the only practical way of case identification for laboratory investigation and infection control. The clinical usefulness of rapid diagnostic laboratory tests requires more vigorous evaluation. The lethality of this disease may reflect systemic viral dissemination, cytokine storm, or alveolar flooding due to inhibition of cellular sodium channels. The present circulating genotype Z is intrinsically resistant to amantadine and rimantadine. Prognosis may be improved by early treatment with a neuraminidase inhibitor with good systemic drug levels, and post-exposure prophylaxis for health care workers is recommended. The role of immunomodulators and other modalities of therapy requires evaluation in randomised controlled trials, with prospective monitoring of the viral load and cytokine profiles in various clinical specimens. In view of the high fatality of the disease, a combination of contact, droplet, and airborne precautions are recommended as long as resources allow despite the fact that the relative importance of these three modes in nosocomial transmission of avian influenza is still unknown.en_HK
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong Medical Journalen_HK
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectHemagglutininsen_HK
dc.subjectHumansen_HK
dc.subjectInfluenza A virus, avianen_HK
dc.subjectInfluenza A virus, humanen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtypeen_HK
dc.subject.meshInfluenza A virus - pathogenicityen_HK
dc.subject.meshInfluenza, Human - epidemiology - pathology - prevention & control - therapyen_HK
dc.subject.meshTerminologyen_HK
dc.subject.meshVirulenceen_HK
dc.titleHuman infection by avian influenza A H5N1en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=11&issue=3&spage=189&epage=199&date=2005&atitle=Human+infection+by+avian+influenza+A+H5N1en_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, SSY:samsonsy@hkucc.hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityWong, SSY=rp00395en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid15951584-
dc.identifier.scopuseid_2-s2.0-20444436368en_HK
dc.identifier.hkuros98789-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20444436368&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue3en_HK
dc.identifier.spage189en_HK
dc.identifier.epage199en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridWong, SSY=13310021400en_HK

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