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Article: N-ras mutations in myelodysplastic syndromes in Hong Kong Chinese

TitleN-ras mutations in myelodysplastic syndromes in Hong Kong Chinese
Authors
KeywordsN-ras mutation
Myelodysplastic syndromes
Hong Kong
Chinese
Dot blot hybridization
Issue Date1995
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org
Citation
Hong Kong Medical Journal, 1995, v. 1 n. 4, p. 290-296 How to Cite?
AbstractHong Kong Chinese patients with myelodysplastic syndromes were screened for the presence of N-ras mutation by using the polymerase chain reaction/dot blot hybridization technique. Three of 20 (15%) cases studied were found to harbour mutant N-ras in the bone marrow mononuclear cell population. One case of refractory anaemia with excess of blasts and with excess of blasts in transformation had substitution of arginine for glutamine at codon 61. A second case of refractory anaemia with excess of blasts had substitution of serine for glycine at codon 12. In this patient, mutant N-ras was detected in a follow up sample taken two months later although there was no change in the blast percentage compared with the presentation sample. Our study showed that N-ras mutation is an infrequent finding in Hong Kong Chinese myelodysplastic syndrome patients. An N-ras mutation is not necessarily accompanied by an alteration in the haematological picture.
Persistent Identifierhttp://hdl.handle.net/10722/53422
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLeung, Pen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorLiang, RHSen_HK
dc.date.accessioned2009-04-03T07:19:20Z-
dc.date.available2009-04-03T07:19:20Z-
dc.date.issued1995en_HK
dc.identifier.citationHong Kong Medical Journal, 1995, v. 1 n. 4, p. 290-296en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53422-
dc.description.abstractHong Kong Chinese patients with myelodysplastic syndromes were screened for the presence of N-ras mutation by using the polymerase chain reaction/dot blot hybridization technique. Three of 20 (15%) cases studied were found to harbour mutant N-ras in the bone marrow mononuclear cell population. One case of refractory anaemia with excess of blasts and with excess of blasts in transformation had substitution of arginine for glutamine at codon 61. A second case of refractory anaemia with excess of blasts had substitution of serine for glycine at codon 12. In this patient, mutant N-ras was detected in a follow up sample taken two months later although there was no change in the blast percentage compared with the presentation sample. Our study showed that N-ras mutation is an infrequent finding in Hong Kong Chinese myelodysplastic syndrome patients. An N-ras mutation is not necessarily accompanied by an alteration in the haematological picture.en_HK
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.orgen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.en_HK
dc.subjectN-ras mutationen_HK
dc.subjectMyelodysplastic syndromesen_HK
dc.subjectHong Kongen_HK
dc.subjectChineseen_HK
dc.subjectDot blot hybridizationen_HK
dc.titleN-ras mutations in myelodysplastic syndromes in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=1&issue=4&spage=290&epage=296&date=1995&atitle=N-ras+mutations+in+myelodysplastic+syndromes+in+Hong+Kong+Chineseen_HK
dc.identifier.emailChan, LC: chanlc@hkucc.hku.hken_HK
dc.identifier.emailLiang, RHS: rliang@hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.hkuros11358-

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