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Article: Persistence of hepatic hepatitis B virus after serological clearance of HBsAG with autologous peripheral stem cell transplantation

TitlePersistence of hepatic hepatitis B virus after serological clearance of HBsAG with autologous peripheral stem cell transplantation
Authors
KeywordsHepatitis B virus
High dose chemotherapy
Lymphoma
Peripheral blood stem cell
Virus persistence
Issue Date1997
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1997, v. 50 n. 8, p. 706-708 How to Cite?
AbstractDelayed clearance of hepatitis B surface antigen was previously reported in a 38 year old woman after high dose chemotherapy with autologous peripheral blood stem cell rescue. Sixteen months later, this patient remained hepatitis B surface antigen negative, hepatitis B surface anti-body positive, and serum hepatitis B DNA negative by polymerase chain reaction. Serial liver biopsies (one at hepatitis B e antigen positive stage, one at hepatitis B e antibody positive stage, and one at hepatitis B surface antigen negative and hepatitis B surface antibody positive stage) showed a gradual resolution of the inflammatory activity with loss of hepatitis B e antigen and then hepatitis B surface antigen in the serum. However, the degree of fibrosis, though mild, remained the same. With the serological clearance of hepatitis B surface antigen, a small amount of hepatitis B virus DNA was still detectable in the nuclei of liver cells.
Persistent Identifierhttp://hdl.handle.net/10722/53417
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, GKKen_HK
dc.contributor.authorWu, PCen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLim, WLen_HK
dc.date.accessioned2009-04-03T07:19:13Z-
dc.date.available2009-04-03T07:19:13Z-
dc.date.issued1997en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1997, v. 50 n. 8, p. 706-708en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53417-
dc.description.abstractDelayed clearance of hepatitis B surface antigen was previously reported in a 38 year old woman after high dose chemotherapy with autologous peripheral blood stem cell rescue. Sixteen months later, this patient remained hepatitis B surface antigen negative, hepatitis B surface anti-body positive, and serum hepatitis B DNA negative by polymerase chain reaction. Serial liver biopsies (one at hepatitis B e antigen positive stage, one at hepatitis B e antibody positive stage, and one at hepatitis B surface antigen negative and hepatitis B surface antibody positive stage) showed a gradual resolution of the inflammatory activity with loss of hepatitis B e antigen and then hepatitis B surface antigen in the serum. However, the degree of fibrosis, though mild, remained the same. With the serological clearance of hepatitis B surface antigen, a small amount of hepatitis B virus DNA was still detectable in the nuclei of liver cells.en_HK
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectHepatitis B virusen_HK
dc.subjectHigh dose chemotherapyen_HK
dc.subjectLymphomaen_HK
dc.subjectPeripheral blood stem cellen_HK
dc.subjectVirus persistenceen_HK
dc.subject.meshHematopoietic Stem Cell Transplantationen_HK
dc.subject.meshHepatitis B - immunology - pathology - therapyen_HK
dc.subject.meshHepatitis B Surface Antigens - blooden_HK
dc.subject.meshHepatitis B virus - isolation & purificationen_HK
dc.subject.meshLiver - immunology - virologyen_HK
dc.titlePersistence of hepatic hepatitis B virus after serological clearance of HBsAG with autologous peripheral stem cell transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=50&issue=8&spage=706&epage=708&date=1997&atitle=Persistence+of+hepatic+hepatitis+B+virus+after+serological+clearance+of+HBsAg+with+autologous+peripheral+stem+cell+transplantationen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9301561-
dc.identifier.pmcidPMC500132-
dc.identifier.scopuseid_2-s2.0-9844256435en_HK
dc.identifier.hkuros27478-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9844256435&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue8en_HK
dc.identifier.spage706en_HK
dc.identifier.epage708en_HK
dc.identifier.isiWOS:A1997XT71500019-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, GKK=7102301257en_HK
dc.identifier.scopusauthoridWu, PC=7403119323en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridLim, WL=24492170000en_HK

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