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Article: Experimentally induced unilateral tooth loss: Histochemical studies of the temporomandibular joint

TitleExperimentally induced unilateral tooth loss: Histochemical studies of the temporomandibular joint
Authors
KeywordsSulfated glycosaminoglycans
Temporomandibular joint
Unilateral mastication
Issue Date2002
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2002, v. 81 n. 3, p. 209-213 How to Cite?
AbstractOcclusal abnormality may contribute to osteoarthrosis of the temporomandibular joint (TMJ). Since mechanical force may induce changes in the extracellular matrix, we tested the hypothesis that unilateral removal of teeth and the resulting unilateral mastication change the content of glycosaminoglycans (GAGs) in the TMJ condyle and disc. Lower-right-side teeth were extracted from 12 adult male rabbits, which were killed 3 or 6 weeks later. Three normal rabbits served as controls. Sections were analyzed for morphological changes and levels of sulfated GAGs in the condyle and disc. Unilateral removal of teeth led to thickening of the condylar cartilage, alterations in the morphology of chondrocyte nuclei in the condylar cartilage and disc, and increases in levels of negatively charged ions in the hypertrophic layer of condylar cartilage. Small differences were observed, after unilateral removal of teeth, between the functional and non-functional sides of the TMJ. The results suggest that in response to mechanical stress, chondrocytes alter sulfated glycosaminoglycan (GAGs) synthesis and degradation rates, resulting in an elevated level of sulfated GAGs in the condylar cartilage.
Persistent Identifierhttp://hdl.handle.net/10722/53315
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, Qen_HK
dc.contributor.authorOpstelten, Den_HK
dc.contributor.authorSamman, Nen_HK
dc.contributor.authorTideman, Hen_HK
dc.date.accessioned2009-04-03T07:12:09Z-
dc.date.available2009-04-03T07:12:09Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Dental Research, 2002, v. 81 n. 3, p. 209-213en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53315-
dc.description.abstractOcclusal abnormality may contribute to osteoarthrosis of the temporomandibular joint (TMJ). Since mechanical force may induce changes in the extracellular matrix, we tested the hypothesis that unilateral removal of teeth and the resulting unilateral mastication change the content of glycosaminoglycans (GAGs) in the TMJ condyle and disc. Lower-right-side teeth were extracted from 12 adult male rabbits, which were killed 3 or 6 weeks later. Three normal rabbits served as controls. Sections were analyzed for morphological changes and levels of sulfated GAGs in the condyle and disc. Unilateral removal of teeth led to thickening of the condylar cartilage, alterations in the morphology of chondrocyte nuclei in the condylar cartilage and disc, and increases in levels of negatively charged ions in the hypertrophic layer of condylar cartilage. Small differences were observed, after unilateral removal of teeth, between the functional and non-functional sides of the TMJ. The results suggest that in response to mechanical stress, chondrocytes alter sulfated glycosaminoglycan (GAGs) synthesis and degradation rates, resulting in an elevated level of sulfated GAGs in the condylar cartilage.en_HK
dc.languageengen_HK
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectSulfated glycosaminoglycansen_HK
dc.subjectTemporomandibular jointen_HK
dc.subjectUnilateral masticationen_HK
dc.titleExperimentally induced unilateral tooth loss: Histochemical studies of the temporomandibular jointen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=81&issue=3&spage=209&epage=213&date=2002&atitle=Experimentally+induced+unilateral+tooth+loss:+histochemical+studies+of+the+temporomandibular+jointen_HK
dc.identifier.emailSamman, N:nsamman@hkucc.hku.hken_HK
dc.identifier.authoritySamman, N=rp00021en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.scopuseid_2-s2.0-0036008964en_HK
dc.identifier.hkuros67845-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036008964&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume81en_HK
dc.identifier.issue3en_HK
dc.identifier.spage209en_HK
dc.identifier.epage213en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHuang, Q=36050366700en_HK
dc.identifier.scopusauthoridOpstelten, D=16237067300en_HK
dc.identifier.scopusauthoridSamman, N=7006413627en_HK
dc.identifier.scopusauthoridTideman, H=7005602469en_HK

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