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Article: PTHrP regulates chondrocyte maturation in condylar cartilage

TitlePTHrP regulates chondrocyte maturation in condylar cartilage
Authors
KeywordsChondrocyte
Condylar cartilage
Differentiation
Maturation
PTHrP
Issue Date2003
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2003, v. 82 n. 8, p. 627-631 How to Cite?
AbstractPTHrP is a key factor regulating the pace of endochondral ossification during skeletal development. Mandibular advancement solicits a cascade of molecular responses in condylar cartilage. However, the pace of cellular maturation and its effects on condylar growth are still unknown. The purpose of this study was to evaluate the pattern of expression of PTHrP and correlate it to cellular dynamics of chondrocytes in condylar cartilage during natural growth and mandibular advancement. We fitted 35-day-old Sprague-Dawley rats with functional appliances. Experimental animals with matched controls were labeled with bromodeoxyuridine 3 days before their death, so that mesenchymal cell differentiation could be traced. Mandibular advancement increased the number of differentiated chondroblasts and subsequently increased the cartilage volume. Higher levels of PTHrP expression in experimental animals coincided with the slowing of chondrocyte hypertrophy. Thus, mandibular advancement promoted mesenchymal cell differentiation and triggered PTHrP expression, which retarded their further maturation to allow for more growth.
Persistent Identifierhttp://hdl.handle.net/10722/53307
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorTang, GHen_HK
dc.contributor.authorXiong, Hen_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2009-04-03T07:06:26Z-
dc.date.available2009-04-03T07:06:26Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Dental Research, 2003, v. 82 n. 8, p. 627-631en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53307-
dc.description.abstractPTHrP is a key factor regulating the pace of endochondral ossification during skeletal development. Mandibular advancement solicits a cascade of molecular responses in condylar cartilage. However, the pace of cellular maturation and its effects on condylar growth are still unknown. The purpose of this study was to evaluate the pattern of expression of PTHrP and correlate it to cellular dynamics of chondrocytes in condylar cartilage during natural growth and mandibular advancement. We fitted 35-day-old Sprague-Dawley rats with functional appliances. Experimental animals with matched controls were labeled with bromodeoxyuridine 3 days before their death, so that mesenchymal cell differentiation could be traced. Mandibular advancement increased the number of differentiated chondroblasts and subsequently increased the cartilage volume. Higher levels of PTHrP expression in experimental animals coincided with the slowing of chondrocyte hypertrophy. Thus, mandibular advancement promoted mesenchymal cell differentiation and triggered PTHrP expression, which retarded their further maturation to allow for more growth.en_HK
dc.languageengen_HK
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectChondrocyteen_HK
dc.subjectCondylar cartilageen_HK
dc.subjectDifferentiationen_HK
dc.subjectMaturationen_HK
dc.subjectPTHrPen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Differentiation - physiologyen_HK
dc.subject.meshCell Division - physiologyen_HK
dc.subject.meshChondrocytes - metabolism - physiologyen_HK
dc.subject.meshColoring Agents - diagnostic useen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGrowth Plate - growth & development - physiologyen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshMandibular Advancementen_HK
dc.subject.meshMandibular Condyle - growth & development - physiologyen_HK
dc.subject.meshMesoderm - physiologyen_HK
dc.subject.meshOrthodontic Appliances, Functionalen_HK
dc.subject.meshParathyroid Hormone - analysis - physiologyen_HK
dc.subject.meshParathyroid Hormone-Related Proteinen_HK
dc.subject.meshPeptide Hormones - analysis - physiologyen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titlePTHrP regulates chondrocyte maturation in condylar cartilageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=82&issue=8&spage=627&epage=631&date=2003&atitle=PTHrP+regulates+chondrocyte+maturation+in+condylar+cartilageen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid12885848-
dc.identifier.scopuseid_2-s2.0-0042386616en_HK
dc.identifier.hkuros95052-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0042386616&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume82en_HK
dc.identifier.issue8en_HK
dc.identifier.spage627en_HK
dc.identifier.epage631en_HK
dc.identifier.isiWOS:000184432400011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridTang, GH=9842004300en_HK
dc.identifier.scopusauthoridXiong, H=36852325600en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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