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Article: Chronic hyperplastic candidosis/candidiasis (candidal leukoplakia)

TitleChronic hyperplastic candidosis/candidiasis (candidal leukoplakia)
Authors
KeywordsCandida
Hyperplastic candidosis
Candidiasis, review
Issue Date2003
PublisherInternational and American Associations for Dental Research. The Journal's web site is located at http://crobm.iadrjournals.org/
Citation
Critical Reviews In Oral Biology And Medicine, 2003, v. 14 n. 4, p. 253-267 How to Cite?
AbstractChronic hyperplastic candidosis/candidiasis (CHC; syn. candidal leukoplakia) is a variant of oral candidosis that typically presents as a white patch on the commissures of the oral mucosa. The major etiologic agent of the disease is the oral fungal pathogen Candida predominantly belonging to Candida albicans, although other systemic co-factors, such as vitamin deficiency and generalized immune suppression, may play a contributory role. Clinically, the lesions are symptomless and regress after appropriate antifungal therapy and correction of underlying nutritional or other deficiencies. If the lesions are untreated, a minor proportion may demonstrate dysplasia and develop into carcinomas. This review outlines the demographic features, etiopathogenesis, immunological features, histopathology, and the role of Candida in the disease process. In the final part of the review, newer molecular biological aspects of the disease are considered together with the management protocols that are currently available, and directions for future research.
Persistent Identifierhttp://hdl.handle.net/10722/53240
ISSN
2006 Impact Factor: 6.0
2007 SCImago Journal Rankings: 2.029
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSitheeque, MAMen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2009-04-03T07:04:55Z-
dc.date.available2009-04-03T07:04:55Z-
dc.date.issued2003en_HK
dc.identifier.citationCritical Reviews In Oral Biology And Medicine, 2003, v. 14 n. 4, p. 253-267en_HK
dc.identifier.issn1045-4411en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53240-
dc.description.abstractChronic hyperplastic candidosis/candidiasis (CHC; syn. candidal leukoplakia) is a variant of oral candidosis that typically presents as a white patch on the commissures of the oral mucosa. The major etiologic agent of the disease is the oral fungal pathogen Candida predominantly belonging to Candida albicans, although other systemic co-factors, such as vitamin deficiency and generalized immune suppression, may play a contributory role. Clinically, the lesions are symptomless and regress after appropriate antifungal therapy and correction of underlying nutritional or other deficiencies. If the lesions are untreated, a minor proportion may demonstrate dysplasia and develop into carcinomas. This review outlines the demographic features, etiopathogenesis, immunological features, histopathology, and the role of Candida in the disease process. In the final part of the review, newer molecular biological aspects of the disease are considered together with the management protocols that are currently available, and directions for future research.en_HK
dc.languageengen_HK
dc.publisherInternational and American Associations for Dental Research. The Journal's web site is located at http://crobm.iadrjournals.org/en_HK
dc.relation.ispartofCritical Reviews in Oral Biology and Medicineen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCandidaen_HK
dc.subjectHyperplastic candidosisen_HK
dc.subjectCandidiasis, reviewen_HK
dc.subject.meshAntifungal Agents - therapeutic useen_HK
dc.subject.meshCandida - genetics - pathogenicityen_HK
dc.subject.meshCandidiasis, Oral - blood - complications - drug therapy - immunology - microbiology - pathologyen_HK
dc.subject.meshChronic Diseaseen_HK
dc.subject.meshDiabetes Complicationsen_HK
dc.subject.meshDisease Susceptibilityen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHyperplasiaen_HK
dc.subject.meshLeukoplakia, Oral - etiology - microbiologyen_HK
dc.titleChronic hyperplastic candidosis/candidiasis (candidal leukoplakia)en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-4411&volume=14&issue=4&spage=253&epage=267&date=2003&atitle=Chronic+Hyperplastic+Candidosis/Candidiasis+(Candidal+leukoplakia)en_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1177/154411130301400403en_HK
dc.identifier.pmid12907694-
dc.identifier.scopuseid_2-s2.0-0041731706en_HK
dc.identifier.hkuros80094-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041731706&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue4en_HK
dc.identifier.spage253en_HK
dc.identifier.epage267en_HK
dc.identifier.isiWOS:000226595200003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSitheeque, MAM=6505934676en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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