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Article: Chronic hyperplastic candidosis/candidiasis (candidal leukoplakia)
Title | Chronic hyperplastic candidosis/candidiasis (candidal leukoplakia) |
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Authors | |
Keywords | Candida Hyperplastic candidosis Candidiasis, review |
Issue Date | 2003 |
Publisher | International and American Associations for Dental Research. The Journal's web site is located at http://crobm.iadrjournals.org/ |
Citation | Critical Reviews In Oral Biology And Medicine, 2003, v. 14 n. 4, p. 253-267 How to Cite? |
Abstract | Chronic hyperplastic candidosis/candidiasis (CHC; syn. candidal leukoplakia) is a variant of oral candidosis that typically presents as a white patch on the commissures of the oral mucosa. The major etiologic agent of the disease is the oral fungal pathogen Candida predominantly belonging to Candida albicans, although other systemic co-factors, such as vitamin deficiency and generalized immune suppression, may play a contributory role. Clinically, the lesions are symptomless and regress after appropriate antifungal therapy and correction of underlying nutritional or other deficiencies. If the lesions are untreated, a minor proportion may demonstrate dysplasia and develop into carcinomas. This review outlines the demographic features, etiopathogenesis, immunological features, histopathology, and the role of Candida in the disease process. In the final part of the review, newer molecular biological aspects of the disease are considered together with the management protocols that are currently available, and directions for future research. |
Persistent Identifier | http://hdl.handle.net/10722/53240 |
ISSN | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sitheeque, MAM | en_HK |
dc.contributor.author | Samaranayake, LP | en_HK |
dc.date.accessioned | 2009-04-03T07:04:55Z | - |
dc.date.available | 2009-04-03T07:04:55Z | - |
dc.date.issued | 2003 | en_HK |
dc.identifier.citation | Critical Reviews In Oral Biology And Medicine, 2003, v. 14 n. 4, p. 253-267 | en_HK |
dc.identifier.issn | 1045-4411 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/53240 | - |
dc.description.abstract | Chronic hyperplastic candidosis/candidiasis (CHC; syn. candidal leukoplakia) is a variant of oral candidosis that typically presents as a white patch on the commissures of the oral mucosa. The major etiologic agent of the disease is the oral fungal pathogen Candida predominantly belonging to Candida albicans, although other systemic co-factors, such as vitamin deficiency and generalized immune suppression, may play a contributory role. Clinically, the lesions are symptomless and regress after appropriate antifungal therapy and correction of underlying nutritional or other deficiencies. If the lesions are untreated, a minor proportion may demonstrate dysplasia and develop into carcinomas. This review outlines the demographic features, etiopathogenesis, immunological features, histopathology, and the role of Candida in the disease process. In the final part of the review, newer molecular biological aspects of the disease are considered together with the management protocols that are currently available, and directions for future research. | en_HK |
dc.language | eng | en_HK |
dc.publisher | International and American Associations for Dental Research. The Journal's web site is located at http://crobm.iadrjournals.org/ | en_HK |
dc.relation.ispartof | Critical Reviews in Oral Biology and Medicine | en_HK |
dc.subject | Candida | en_HK |
dc.subject | Hyperplastic candidosis | en_HK |
dc.subject | Candidiasis, review | en_HK |
dc.subject.mesh | Antifungal Agents - therapeutic use | en_HK |
dc.subject.mesh | Candida - genetics - pathogenicity | en_HK |
dc.subject.mesh | Candidiasis, Oral - blood - complications - drug therapy - immunology - microbiology - pathology | en_HK |
dc.subject.mesh | Chronic Disease | en_HK |
dc.subject.mesh | Diabetes Complications | en_HK |
dc.subject.mesh | Disease Susceptibility | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Hyperplasia | en_HK |
dc.subject.mesh | Leukoplakia, Oral - etiology - microbiology | en_HK |
dc.title | Chronic hyperplastic candidosis/candidiasis (candidal leukoplakia) | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-4411&volume=14&issue=4&spage=253&epage=267&date=2003&atitle=Chronic+Hyperplastic+Candidosis/Candidiasis+(Candidal+leukoplakia) | en_HK |
dc.identifier.email | Samaranayake, LP:lakshman@hku.hk | en_HK |
dc.identifier.authority | Samaranayake, LP=rp00023 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.doi | 10.1177/154411130301400403 | en_HK |
dc.identifier.pmid | 12907694 | - |
dc.identifier.scopus | eid_2-s2.0-0041731706 | en_HK |
dc.identifier.hkuros | 80094 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0041731706&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 14 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 253 | en_HK |
dc.identifier.epage | 267 | en_HK |
dc.identifier.isi | WOS:000226595200003 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Sitheeque, MAM=6505934676 | en_HK |
dc.identifier.scopusauthorid | Samaranayake, LP=7102761002 | en_HK |
dc.identifier.issnl | 1045-4411 | - |