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Article: Indian hedgehog: A mechanotransduction mediator in condylar cartilage

TitleIndian hedgehog: A mechanotransduction mediator in condylar cartilage
Authors
KeywordsCell cycle
Condylar cartilage
Ihh
Mechanical stress
Proliferation
Issue Date2004
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2004, v. 83 n. 5, p. 434-438 How to Cite?
AbstractIndian hedgehog (Ihh) is a critical mediator transducing mechanical signals to stimulate chondrocyte proliferation. To clarify the cellular signal transduction pathway that senses and converts mechanical signals into tissue growth in mandibular condyle, we evaluated Ihh expression and its relation to the kinetics of replicating mesenchymal cells in condylar cartilage during natural growth and mandibular advancement. Thirty-five-day-old Sprague-Dawley rats were fitted with functional appliances. Experimental animals with matched controls were doubly labeled with iododeoxyuridine and bromodeoxyuridine so that we could evaluate the cycles of the proliferative mesenchymal cells. Mandibular advancement triggered Ihh expression in condylar cartilage. A higher level of Ihh expression coincided with the increase of the replicating mesenchymal cells' population and the shortening of the turnover time. These findings suggested that Ihh acts as a mediator of mechanotransduction that converts mechanical signals resulting from anterior mandibular displacement to stimulate cellular proliferation in condylar cartilage.
Persistent Identifierhttp://hdl.handle.net/10722/53217
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, GHen_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2009-04-03T07:04:23Z-
dc.date.available2009-04-03T07:04:23Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Dental Research, 2004, v. 83 n. 5, p. 434-438en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53217-
dc.description.abstractIndian hedgehog (Ihh) is a critical mediator transducing mechanical signals to stimulate chondrocyte proliferation. To clarify the cellular signal transduction pathway that senses and converts mechanical signals into tissue growth in mandibular condyle, we evaluated Ihh expression and its relation to the kinetics of replicating mesenchymal cells in condylar cartilage during natural growth and mandibular advancement. Thirty-five-day-old Sprague-Dawley rats were fitted with functional appliances. Experimental animals with matched controls were doubly labeled with iododeoxyuridine and bromodeoxyuridine so that we could evaluate the cycles of the proliferative mesenchymal cells. Mandibular advancement triggered Ihh expression in condylar cartilage. A higher level of Ihh expression coincided with the increase of the replicating mesenchymal cells' population and the shortening of the turnover time. These findings suggested that Ihh acts as a mediator of mechanotransduction that converts mechanical signals resulting from anterior mandibular displacement to stimulate cellular proliferation in condylar cartilage.en_HK
dc.languageengen_HK
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCell cycleen_HK
dc.subjectCondylar cartilageen_HK
dc.subjectIhhen_HK
dc.subjectMechanical stressen_HK
dc.subjectProliferationen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBromodeoxyuridine - diagnostic useen_HK
dc.subject.meshCartilage - cytology - growth & developmenten_HK
dc.subject.meshCell Division - physiologyen_HK
dc.subject.meshChondrocytes - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHedgehog Proteinsen_HK
dc.subject.meshIdoxuridine - diagnostic useen_HK
dc.subject.meshMandibular Advancementen_HK
dc.subject.meshMandibular Condyle - cytology - growth & developmenten_HK
dc.subject.meshMechanotransduction, Cellular - physiologyen_HK
dc.subject.meshMesoderm - cytologyen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshS Phase - physiologyen_HK
dc.subject.meshStaining and Labelingen_HK
dc.subject.meshTrans-Activators - physiologyen_HK
dc.titleIndian hedgehog: A mechanotransduction mediator in condylar cartilageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=83&issue=5&spage=434&epage=438&date=2004&atitle=Indian+hedgehog:+a+mechanotransduction+mediator+in+condylar+cartilageen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid15111639-
dc.identifier.scopuseid_2-s2.0-2442681981en_HK
dc.identifier.hkuros95055-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2442681981&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume83en_HK
dc.identifier.issue5en_HK
dc.identifier.spage434en_HK
dc.identifier.epage438en_HK
dc.identifier.isiWOS:000226597500016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTang, GH=9842004300en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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