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- PMID: 15111639
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Article: Indian hedgehog: A mechanotransduction mediator in condylar cartilage
Title | Indian hedgehog: A mechanotransduction mediator in condylar cartilage |
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Authors | |
Keywords | Cell cycle Condylar cartilage Ihh Mechanical stress Proliferation |
Issue Date | 2004 |
Publisher | Sage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925 |
Citation | Journal Of Dental Research, 2004, v. 83 n. 5, p. 434-438 How to Cite? |
Abstract | Indian hedgehog (Ihh) is a critical mediator transducing mechanical signals to stimulate chondrocyte proliferation. To clarify the cellular signal transduction pathway that senses and converts mechanical signals into tissue growth in mandibular condyle, we evaluated Ihh expression and its relation to the kinetics of replicating mesenchymal cells in condylar cartilage during natural growth and mandibular advancement. Thirty-five-day-old Sprague-Dawley rats were fitted with functional appliances. Experimental animals with matched controls were doubly labeled with iododeoxyuridine and bromodeoxyuridine so that we could evaluate the cycles of the proliferative mesenchymal cells. Mandibular advancement triggered Ihh expression in condylar cartilage. A higher level of Ihh expression coincided with the increase of the replicating mesenchymal cells' population and the shortening of the turnover time. These findings suggested that Ihh acts as a mediator of mechanotransduction that converts mechanical signals resulting from anterior mandibular displacement to stimulate cellular proliferation in condylar cartilage. |
Persistent Identifier | http://hdl.handle.net/10722/53217 |
ISSN | 2021 Impact Factor: 8.924 2020 SCImago Journal Rankings: 1.979 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Tang, GH | en_HK |
dc.contributor.author | Rabie, ABM | en_HK |
dc.contributor.author | Hägg, U | en_HK |
dc.date.accessioned | 2009-04-03T07:04:23Z | - |
dc.date.available | 2009-04-03T07:04:23Z | - |
dc.date.issued | 2004 | en_HK |
dc.identifier.citation | Journal Of Dental Research, 2004, v. 83 n. 5, p. 434-438 | en_HK |
dc.identifier.issn | 0022-0345 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/53217 | - |
dc.description.abstract | Indian hedgehog (Ihh) is a critical mediator transducing mechanical signals to stimulate chondrocyte proliferation. To clarify the cellular signal transduction pathway that senses and converts mechanical signals into tissue growth in mandibular condyle, we evaluated Ihh expression and its relation to the kinetics of replicating mesenchymal cells in condylar cartilage during natural growth and mandibular advancement. Thirty-five-day-old Sprague-Dawley rats were fitted with functional appliances. Experimental animals with matched controls were doubly labeled with iododeoxyuridine and bromodeoxyuridine so that we could evaluate the cycles of the proliferative mesenchymal cells. Mandibular advancement triggered Ihh expression in condylar cartilage. A higher level of Ihh expression coincided with the increase of the replicating mesenchymal cells' population and the shortening of the turnover time. These findings suggested that Ihh acts as a mediator of mechanotransduction that converts mechanical signals resulting from anterior mandibular displacement to stimulate cellular proliferation in condylar cartilage. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Sage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925 | en_HK |
dc.relation.ispartof | Journal of Dental Research | en_HK |
dc.subject | Cell cycle | en_HK |
dc.subject | Condylar cartilage | en_HK |
dc.subject | Ihh | en_HK |
dc.subject | Mechanical stress | en_HK |
dc.subject | Proliferation | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Bromodeoxyuridine - diagnostic use | en_HK |
dc.subject.mesh | Cartilage - cytology - growth & development | en_HK |
dc.subject.mesh | Cell Division - physiology | en_HK |
dc.subject.mesh | Chondrocytes - physiology | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Hedgehog Proteins | en_HK |
dc.subject.mesh | Idoxuridine - diagnostic use | en_HK |
dc.subject.mesh | Mandibular Advancement | en_HK |
dc.subject.mesh | Mandibular Condyle - cytology - growth & development | en_HK |
dc.subject.mesh | Mechanotransduction, Cellular - physiology | en_HK |
dc.subject.mesh | Mesoderm - cytology | en_HK |
dc.subject.mesh | Random Allocation | en_HK |
dc.subject.mesh | Rats | en_HK |
dc.subject.mesh | Rats, Sprague-Dawley | en_HK |
dc.subject.mesh | S Phase - physiology | en_HK |
dc.subject.mesh | Staining and Labeling | en_HK |
dc.subject.mesh | Trans-Activators - physiology | en_HK |
dc.title | Indian hedgehog: A mechanotransduction mediator in condylar cartilage | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=83&issue=5&spage=434&epage=438&date=2004&atitle=Indian+hedgehog:+a+mechanotransduction+mediator+in+condylar+cartilage | en_HK |
dc.identifier.email | Rabie, ABM: rabie@hku.hk | en_HK |
dc.identifier.email | Hägg, U: euohagg@hkusua.hku.hk | en_HK |
dc.identifier.authority | Rabie, ABM=rp00029 | en_HK |
dc.identifier.authority | Hägg, U=rp00020 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.doi | 10.1177/154405910408300516 | - |
dc.identifier.pmid | 15111639 | - |
dc.identifier.scopus | eid_2-s2.0-2442681981 | en_HK |
dc.identifier.hkuros | 95055 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-2442681981&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 83 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 434 | en_HK |
dc.identifier.epage | 438 | en_HK |
dc.identifier.isi | WOS:000226597500016 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Tang, GH=9842004300 | en_HK |
dc.identifier.scopusauthorid | Rabie, ABM=7007172734 | en_HK |
dc.identifier.scopusauthorid | Hägg, U=7006790279 | en_HK |
dc.identifier.issnl | 0022-0345 | - |